This P60 application from the University of Connecticut Alcohol Research Center (UCONN ARC) requests five years of continued funding for the Center's research programs on vulnerability to alcohol dependence and promising biological and psychosocial treatment interventions. Component I describes the UConn ARC's organizational framework, quality control mechanisms related to research and publications, and supporting research facilities. The visiting scholars program, consulting and mentoring activities and journal editorship activities strengthen the UConn ARC'S role as a regional and national resource. Component II focuses on neurophysiologic, psychological, and genetic factors to predict risky drinking behavior / binge drinking and obesity risk among college age females. Component III, a second study of vulnerability, will focus on several stress-related pathways (including genetic) that may increase the susceptibility for developing heavy drinking and alcohol-related problems among college students after graduation. Continuing our Center's emphasis on novel treatments, we propose two new studies. Component IV builds upon current work and will evaluate the efficacy of Contingency Management as alcohol use is continuously monitored electronically vs. standard treatment. Eighteen month follow-up evaluations will examine drinking outcomes and the effects of CM on reducing other drug use, psychosocial problems, predictors of relapse, and the interaction of GABRA2 genotype with treatment conditions. Component V is a placebo controlled trial to evaluate the safety and efficacy of dutasteride. Reductions in drinking, the persistence of treatment effects, and the role of GABA alleles and AKR1C3 genotype in moderating the treatment response will also be examined. Component VI describes a program of translational, dissemination and educational activities that are integrated with the Center's theme, investigators, and research programs. Finally, the proposed pilot studies component (VII) will support six studies that relate directly to the Center'themes of vulnerability and novel treatments for alcohol dependence and help better position the Center with respect to the new UCONN capital improvement (Bioscience CT) and science (Jackson Laboratories) initiatives.

Public Health Relevance

The UCONN ARC has two primary aims: 1) the identification of social, psychological and biological factors that contribute to an adolescent's vulnerability fo developing alcohol problems, including alcohol dependence, and 2) developing more effective behavioral and pharmacological treatments for problem drinkers and persons with alcohol dependence. Our research findings have been used to improve both prevention programs and to improve treatment approaches.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Comprehensive Center (P60)
Project #
2P60AA003510-36
Application #
8396622
Study Section
Special Emphasis Panel (ZAA1-GG (50))
Program Officer
Huebner, Robert B
Project Start
1978-03-01
Project End
2017-11-30
Budget Start
2012-12-25
Budget End
2013-11-30
Support Year
36
Fiscal Year
2013
Total Cost
$1,800,326
Indirect Cost
$657,638
Name
University of Connecticut
Department
Psychiatry
Type
Schools of Medicine
DUNS #
022254226
City
Farmington
State
CT
Country
United States
Zip Code
06030
Weiss, Nicole H; Bold, Krysten W; Contractor, Ateka A et al. (2018) Trauma exposure and heavy drinking and drug use among college students: Identifying the roles of negative and positive affect lability in a daily diary study. Addict Behav 79:131-137
Armeli, Stephen; Covault, Jonathan; Tennen, Howard (2018) Long-term changes in the effects of episode-specific drinking to cope motivation on daily well-being. Psychol Addict Behav 32:715-726
Higgins-Biddle, John C; Babor, Thomas F (2018) A review of the Alcohol Use Disorders Identification Test (AUDIT), AUDIT-C, and USAUDIT for screening in the United States: Past issues and future directions. Am J Drug Alcohol Abuse 44:578-586
Petry, Nancy M; Zajac, Kristyn; Ginley, Meredith K (2018) Behavioral Addictions as Mental Disorders: To Be or Not To Be? Annu Rev Clin Psychol 14:399-423
Lieberman, Richard; Kranzler, Henry R; Levine, Eric S et al. (2018) Examining the effects of alcohol on GABAA receptor mRNA expression and function in neural cultures generated from control and alcohol dependent donor induced pluripotent stem cells. Alcohol 66:45-53
Bauer, Lance O (2018) Inter-trial variability in brain activity as an indicator of synergistic effects of HIV-1 and drug abuse. Drug Alcohol Depend 191:300-308
Rash, Carla J; Petry, Nancy M; Alessi, Sheila M (2018) A randomized trial of contingency management for smoking cessation in the homeless. Psychol Addict Behav 32:141-148
Bauer, Lance O (2018) HIV/AIDS and an overweight body mass are associated with excessive intra-individual variability in response preparation. J Neurovirol 24:577-586
Petry, Nancy M; Alessi, Sheila M; Rash, Carla J et al. (2018) A randomized trial of contingency management reinforcing attendance at treatment: Do duration and timing of reinforcement matter? J Consult Clin Psychol 86:799-809
Petry, Nancy M; Ginley, Meredith K; Rash, Carla J (2017) A systematic review of treatments for problem gambling. Psychol Addict Behav 31:951-961

Showing the most recent 10 out of 238 publications