FDA approved pharmacotherapy options for alcohol use disorders remain limited, with only three currently approved compounds (disulfiram, naltrexone and acamprosate). Recent studies highlight the potential for medications used for the treatment of other indications to be examined for the treatment of alcohol use disorders. Study of additional agents, particularly those that act through novel mechanisms, is needed to expand the range of pharmacotherapy options for alcohol use problems. Extensive preclinical studies indicate that neuroactive steroids medicate important effects of alcohol and support the examination of neuroactive steroid modulators as treatment options for alcohol use problems. Dutasteride, a widely prescribed medication for benign prostatic hypertrophy, bloci

Public Health Relevance

Heavy drinking remains a significant public health problem. Although several medications have been shown to help patients stop or reduce drinking, additional medication options are needed as there is considerable variablitity in effectiveness or tolerability of existing medications for individual patients. This study will examine a medication approved for other conditions for its potential use to help men reduce or stop drinking.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Comprehensive Center (P60)
Project #
2P60AA003510-36
Application #
8401273
Study Section
Special Emphasis Panel (ZAA1-GG (50))
Project Start
Project End
Budget Start
2012-12-25
Budget End
2013-11-30
Support Year
36
Fiscal Year
2013
Total Cost
$287,892
Indirect Cost
$117,758
Name
University of Connecticut
Department
Type
DUNS #
022254226
City
Farmington
State
CT
Country
United States
Zip Code
06030
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Bauer, Lance O (2018) Inter-trial variability in brain activity as an indicator of synergistic effects of HIV-1 and drug abuse. Drug Alcohol Depend 191:300-308
Rash, Carla J; Petry, Nancy M; Alessi, Sheila M (2018) A randomized trial of contingency management for smoking cessation in the homeless. Psychol Addict Behav 32:141-148
Bauer, Lance O (2018) HIV/AIDS and an overweight body mass are associated with excessive intra-individual variability in response preparation. J Neurovirol 24:577-586
Petry, Nancy M; Alessi, Sheila M; Rash, Carla J et al. (2018) A randomized trial of contingency management reinforcing attendance at treatment: Do duration and timing of reinforcement matter? J Consult Clin Psychol 86:799-809
Petry, Nancy M; Ginley, Meredith K; Rash, Carla J (2017) A systematic review of treatments for problem gambling. Psychol Addict Behav 31:951-961

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