Contingency management (CM) is highly efficacious for reducing substance use, and recent data suggest that reinforcing attendance at treatment can significantly improve treatment outcomes. Importantly, CM interventions that reinforce attendance are more likely to be adopted clinically than those that reinforce abstinence. Having objective indicators of drinking outcomes, nevertheless, is critical for quantifying the benefits of attendance-based CM treatment in alcohol abusing populations. New technology is now available to gauge alcohol use in patients'natural environments. The Secure Continuous Remote Alcohol Monitor (SCRAMx?) continuously monitors alcohol consumption 24 hours a day. As such, it may be ideal for objective evaluation of alcohol consumption during treatment intervention studies, including those that involve CM. In this study, 114 patients participating in community based outpatient treatment programs for alcohol use disorders will wear SCRAMx for a 12-week period. They will be randomized to standard care or standard care plus CM, with reinforcement contingent upon attendance at treatment. We will assess treatment attendance and alcohol use via SCRAMx and self reports. We expect that patients randomized to the CM intervention will remain in treatment longer and show reductions in both SCRAMx assessed and self reported drinking days relative to those randomized to standard care. Long-term follow-up evaluations will examine drinking outcomes for 12 months. We will also estimate net benefits of CM from both the clinic's and society's perspectives, as well as its cost-effectiveness. In addition, we will assess predictors of relapse, focusing on the associations of GABRA2 and nearby GABRG1 genotypes with differential treatment response. Secondary analyses will evaluate the effects of CM on reducing other drug use, psychosocial problems, and HIV risk behaviors, which have been closely linked with alcohol consumption. Results from this study will be important for guiding future research and clinical use of SCRAMx, and paving the way toward integrating CM into clinical practice for the treatment of alcohol use disorders.

Public Health Relevance

Contingency management (CM) is highly efficacious in reducing illicit drug use, but technological limitations have hindered its application to alcohol use. This study will evaluate if reinforcing treatment attendance is efficacious in reducing drinking using a new technology. Findings will be instrumental for determining ultimate dissemination of attendance-based CM, and will guide future use of this technology

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Comprehensive Center (P60)
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Special Emphasis Panel (ZAA1-GG)
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University of Connecticut
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Petry, Nancy M; Alessi, Sheila M; Byrne, Shannon et al. (2015) Reinforcing adherence to antihypertensive medications. J Clin Hypertens (Greenwich) 17:33-8
O'Hara, Ross E; Armeli, Stephen; Tennen, Howard (2015) College students' drinking motives and social-contextual factors: Comparing associations across levels of analysis. Psychol Addict Behav 29:420-9
Petry, Nancy M; Alessi, Sheila M; Barry, Danielle et al. (2015) Standard magnitude prize reinforcers can be as efficacious as larger magnitude reinforcers in cocaine-dependent methadone patients. J Consult Clin Psychol 83:464-72
O'Hara, Ross E; Armeli, Stephen; Tennen, Howard (2014) College students' daily-level reasons for not drinking. Drug Alcohol Rev 33:412-9
O'Hara, Ross E; Armeli, Stephen; Tennen, Howard (2014) Drinking-to-cope motivation and negative mood-drinking contingencies in a daily diary study of college students. J Stud Alcohol Drugs 75:606-14
Andrade, Leonardo F; Barry, Danielle; Litt, Mark D et al. (2014) Maintaining high activity levels in sedentary adults with a reinforcement-thinning schedule. J Appl Behav Anal 47:523-36
Arias, Albert J; Covault, Jonathan; Feinn, Richard et al. (2014) A GABRA2 variant is associated with increased stimulation and 'high' following alcohol administration. Alcohol Alcohol 49:1-9
Weiss, Lindsay M; Petry, Nancy M (2014) Substance abuse treatment patients with early onset cocaine use respond as well to contingency management interventions as those with later onset cocaine use. J Subst Abuse Treat 47:146-50
Milivojevic, Verica; Feinn, Richard; Kranzler, Henry R et al. (2014) Variation in AKR1C3, which encodes the neuroactive steroid synthetic enzyme 3?-HSD type 2 (17?-HSD type 5), moderates the subjective effects of alcohol. Psychopharmacology (Berl) 231:3597-608
Kranzler, Henry R; Armeli, Stephen; Feinn, Richard et al. (2014) GRIK1 genotype moderates topiramate's effects on daily drinking level, expectations of alcohol's positive effects and desire to drink. Int J Neuropsychopharmacol 17:1549-56

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