Evidence indicates a robust association between reports of drinking to cope with stress and alcohol use disorders (AUD) symptoms among young adults. Yet inconsistent findings have been observed for the association between life stress and drinking levels and genetic and social learning risk factors that modify this relationship. One important reason for these weak findings, we believe, is the almost exclusive reliance on checklists to measure life stress, despite their questionable validity. Using a state-of-the-science interview assessment of life stress, and recruiting a large and well characterized sample of post-college young adults, the first aim of the proposed study is to determine whether 5-HTTLPR genotype S' allele carriers, individuals with strong positive alcohol outcome expectancies, and individuals with avoidance coping styles show stronger associations between life stress and drinking levels, coping-related drinking and AUD symptoms.
Our second aim i s to examine whether aspects of adult role attainment, such as enhanced coping and role related stress buffer and/or exacerbate the effects outlined in the first aim. We will also examine the moderating effects other relevant candidate genes. In this study, moderate to heavy drinking participants in our soon to be completed ARC college drinking study, who have provided DNA to address this study's aims, will be contacted approximately 5 years after participation in the college study (N after attrition = 950). They will complete an intensive semi-structured phone interview assessing chronic and epsiodic stress during the previous year, and a detailed assessment of post-college role attainment, role-related coping resources and role stress. Through an Internet-based survey they will also complete standard measues of alcohol outcome expectancies and avoidance coping style, and retrospective reports of alcohol use quantity and frequency, reasons for drinking and AUD symptoms. Participants will then report their daily drinking and reasons for drinking in a 30-day Internet-based daily diary. Results from this study will be important in terms of identifying individuals at risk for stress-related drinking and development of AUDs in early adulthood.

Public Health Relevance

costs of alcohol abuse and dependence, the ability to identify young adults at high risk for continued problematic use during the transition to adulthood is critical. Findings from this study should increase our understanding of the interaction of psychological and genetic risk factors for risky drinking, abuse and dependence in young adulthood.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Comprehensive Center (P60)
Project #
5P60AA003510-40
Application #
9180658
Study Section
Special Emphasis Panel (ZAA1)
Project Start
Project End
Budget Start
2016-12-01
Budget End
2017-11-30
Support Year
40
Fiscal Year
2017
Total Cost
Indirect Cost
Name
University of Connecticut
Department
Type
DUNS #
022254226
City
Farmington
State
CT
Country
United States
Zip Code
06030
Weiss, Nicole H; Bold, Krysten W; Sullivan, Tami P et al. (2017) Testing bidirectional associations among emotion regulation strategies and substance use: a daily diary study. Addiction 112:695-704
Petry, Nancy M; Ginley, Meredith K; Rash, Carla J (2017) A systematic review of treatments for problem gambling. Psychol Addict Behav 31:951-961
Bauer, L O; Houston, R J (2017) The value of instability: an investigation of intrasubject variability in brain activity among obese adolescent girls. Int J Obes (Lond) 41:1489-1495
Meredith, Steven E; Rash, Carla J; Petry, Nancy M (2017) Alcohol use disorders are associated with increased HIV risk behaviors in cocaine-dependent methadone patients. J Subst Abuse Treat 83:10-14
Chartier, Karen G; Hesselbrock, Michie N; Hesselbrock, Victor M (2017) Conclusion: Special issue on genetic and alcohol use disorder research with diverse racial/ethnic groups: Key findings and potential next steps. Am J Addict 26:532-537
Burch, Ashley E; Rash, Carla J; Petry, Nancy M (2017) Cocaine-using substance abuse treatment patients with and without HIV respond well to contingency management treatment. J Subst Abuse Treat 77:21-25
Rash, Carla J; Stitzer, Maxine; Weinstock, Jeremiah (2017) Contingency Management: New Directions and Remaining Challenges for An Evidence-Based Intervention. J Subst Abuse Treat 72:10-18
Rash, Carla J; Alessi, Sheila M; Petry, Nancy M (2017) Substance Abuse Treatment Patients in Housing Programs Respond to Contingency Management Interventions. J Subst Abuse Treat 72:97-102
Howland, Maryhope; Armeli, Stephen; Feinn, Richard et al. (2017) Daily emotional stress reactivity in emerging adulthood: temporal stability and its predictors. Anxiety Stress Coping 30:121-132
Lieberman, Richard; Kranzler, Henry R; Levine, Eric S et al. (2017) Examining FKBP5 mRNA expression in human iPSC-derived neural cells. Psychiatry Res 247:172-181

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