We propose to use an agent-based modeling approach to elucidate specific mechanisms underlying alcohol-related problems and provide a framework for developing comprehensive preventive interventions at the community level. Agent-based models are a tool to assess the health impacts of specific social mechanisms that support alcohol problems in community settings within a framework in which drinkers move through their environments (e.g., commute to home or school) and interact with each other and their environments in ecologically realistic ways (e.g., eat dinner with their families at home). This modeling process demands a high level of precision with regard to theoretical statements of social processes and makes explicit those processes in which we might creatively intervene to reduce problems, setting a high bar for scientific explanation. In this Center component, we will use the Framework for Reconstructing Epidemiologic Dynamics (FRED) platform, an agent-based model with realistic, open-access Census-based synthetic populations that capture the demographic and geographic heterogeneities of the population of the United States down to the Census Block level and allows agents to co-evolve with physical and social environments. We will: (1) Apply a behavioral risk model framework within FRED in order to help clarify specific social ecological mechanisms that underlie the etiology of alcohol-related problems in California communities; and (2) Develop a select set of scenarios to alter social ecological mechanisms related to drinking contexts and assess their effects on alcohol-related problems using the FRED platform. We will extend FRED?s capacities to include unique agent-environment dynamics typical of behavioral risk models related to alcohol use, alcohol use disorders, and related problems. A simulation platform must have a core set of capabilities in order to undertake the development of these behavioral risk models. These include the ability to model individual heterogeneities, heterogeneous agent interactions, and environmental heterogeneity, all of which are built into FRED. We will construct a set of models that accurately describe drinking agents, drinker movements, drinking environments, and specific risks within specific environments. Once the models have been constructed, we will change one element (e.g., increase the number of bars in a community by 10%) and measure how it impacts our outcomes of interest. We will apply this modeling approach to at least five kinds of problems based on current and prior Center Grant research: (a) Parents? abuse and neglect of their children; (b) Early initiation of alcohol use and youth drinking problems (Component #3); (c) Health impacts related to hyper-availability of alcohol at the US-Mexico border (Component #4); (d) AUDs, heavy drinking and problems related to drinking outside the home (Component #5); and (e) The impact of social host ordinances on underage heavy drinking. BRMs allow for the integration of drinking agents and behaviors with drinking contexts?an essential step in designing and implementing effective strategies to prevent and reduce drinking problems within community systems. They make explicit those processes in which we might creatively intervene to reduce problems.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Comprehensive Center (P60)
Project #
Application #
Study Section
Special Emphasis Panel (ZAA1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Pacific Institute for Research and Evaluation
United States
Zip Code
Miller, Ted R; Nygaard, Peter; Gaidus, Andrew et al. (2017) Heterogeneous Costs of Alcohol and Drug Problems Across Cities and Counties in California. Alcohol Clin Exp Res 41:758-768
Lipperman-Kreda, Sharon; Paschall, Mallie J; Robert F, Saltz et al. (2017) Places and social contexts associated with simultaneous use of alcohol, tobacco and marijuana among young adults. Drug Alcohol Rev :
Lipperman-Kreda, Sharon; Gruenewald, Paul J; Bersamin, Melina et al. (2017) Adolescent drinking in different contexts: What behaviors do parents control? Addict Behav Rep 6:39-44
Lloyd, Margaret H; Kepple, Nancy Jo (2017) Unpacking the parallel effects of parental alcohol misuse and low income on risk of supervisory neglect. Child Abuse Negl 69:72-84
Lipperman-Kreda, Sharon; Finan, Laura J; Grube, Joel W (2017) Social and situational characteristics associated with adolescents' drinking at party and non-party events. Addict Behav :
Lipperman-Kreda, Sharon; Gruenewald, Paul J; Grube, Joel W et al. (2017) Adolescents, alcohol, and marijuana: Context characteristics and problems associated with simultaneous use. Drug Alcohol Depend 179:55-60
Wolf, Jennifer Price; Freisthler, Bridget; Kepple, Nancy Jo et al. (2017) The places parents go: understanding the breadth, scope, and experiences of activity spaces for parents. GeoJournal 82:355-368
Freisthler, Bridget; Thomas, Crystal A; Curry, Susanna R et al. (2016) An Alternative to Residential Neighborhoods: An Exploratory Study of how Activity Spaces and Perception of Neighborhood Social Processes relate to Maladaptive Parenting. Child Youth Care Forum 45:259-277
Freisthler, Bridget; Ponicki, William R; Gaidus, Andrew et al. (2016) A micro-temporal geospatial analysis of medical marijuana dispensaries and crime in Long Beach, California. Addiction 111:1027-35
Lipperman-Kreda, Sharon; Grube, Joel W; Friend, Karen B et al. (2016) Tobacco outlet density, retailer cigarette sales without ID checks and enforcement of underage tobacco laws: associations with youths' cigarette smoking and beliefs. Addiction 111:525-32

Showing the most recent 10 out of 112 publications