AdminCore The Administrative Core will provide leadership in research, research methodology development, and information dissemination on topics relevant to our overall TSRI- Alcohol Research Center (ARC) goal. The focus of our renewal is that dysregulation in the brain stress system mediates the transition from acute withdrawaltoprotractedabstinencetopromotevulnerabilitytorelapse,andourARCisdesignedtotranslate the discoveries of preclinical TSRI-ARC investigators for potential therapeutic use using proof-of-concept humanlaboratorytesting.ItcoordinatesallTSRI-ARCactivities,andwillhelpsupportandcoordinatetheTSRI- ARC with the Center at Large. Functions of the Administrative Core will be to provide scientific and administrative leadership for the by monitoring and enhancing collaborative interactions among the support Core and Research Components, to facilitate the dissemination of expertise between support Core and Research Components by organizing regular TSRI-ARC meetings, seminars, conferences and workshops to stimulate exchange of scientific information among the Center faculty and staff, to promote the sharing of multidisciplinary resources and services among the support Core components and investigators, and to disseminatenewresearchknowledgetoacademic,treatmentandlaycommunitiesbyengagingincommunity outreach activities designed to improve awareness, prevention and treatment of alcoholism and alcoholic diseases, and supporting regional and national research initiatives aimed at improving prevention and treatment of alcohol use disorders and addiction. It will arrange regular meetings of the Steering Committee andProgramAdvisoryCommitteeandmonthlymeetingsoftheParticipatingInvestigators.TheAdministrative CoreisorganizedtoensureproperfunctioningoftheCentertobenefitinvestigators,theirutilizationofCenter resources to enhance and expand alcohol research throughout the TSRI-ARC and Center at Large, and to providereviewandadvisoryfunctions.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Comprehensive Center (P60)
Project #
2P60AA006420-35
Application #
9393653
Study Section
Special Emphasis Panel (ZAA1)
Project Start
Project End
Budget Start
2018-01-01
Budget End
2018-12-31
Support Year
35
Fiscal Year
2018
Total Cost
Indirect Cost
Name
Scripps Research Institute
Department
Type
DUNS #
781613492
City
La Jolla
State
CA
Country
United States
Zip Code
92037
Logrip, Marian L; Oleata, Christopher; Roberto, Marisa (2017) Sex differences in responses of the basolateral-central amygdala circuit to alcohol, corticosterone and their interaction. Neuropharmacology 114:123-134
Natividad, Luis A; Buczynski, Matthew W; Herman, Melissa A et al. (2017) Constitutive Increases in Amygdalar Corticotropin-Releasing Factor and Fatty Acid Amide Hydrolase Drive an Anxious Phenotype. Biol Psychiatry 82:500-510
Kimbrough, Adam; de Guglielmo, Giordano; Kononoff, Jenni et al. (2017) CRF1 Receptor-Dependent Increases in Irritability-Like Behavior During Abstinence from Chronic Intermittent Ethanol Vapor Exposure. Alcohol Clin Exp Res 41:1886-1895
Mason, Barbara J (2017) Emerging pharmacotherapies for alcohol use disorder. Neuropharmacology 122:244-253
Luczak, Susan E; Liang, Tiebing; Wall, Tamara L (2017) Age of Drinking Initiation as a Risk Factor for Alcohol Use Disorder Symptoms is Moderated by ALDH2*2 and Ethnicity. Alcohol Clin Exp Res 41:1738-1744
Irimia, Cristina; Buczynski, Matthew W; Natividad, Luis A et al. (2017) Dysregulated Glycine Signaling Contributes to Increased Impulsivity during Protracted Alcohol Abstinence. J Neurosci 37:1853-1861
Melroy-Greif, Whitney E; Wilhelmsen, Kirk C; Yehuda, Rachel et al. (2017) Genome-Wide Association Study of Post-Traumatic Stress Disorder in Two High-Risk Populations. Twin Res Hum Genet 20:197-207
Varodayan, Florence P; Bajo, Michal; Soni, Neeraj et al. (2017) Chronic alcohol exposure disrupts CB1 regulation of GABAergic transmission in the rat basolateral amygdala. Addict Biol 22:766-778
Roberto, Marisa; Varodayan, Florence P (2017) Synaptic targets: Chronic alcohol actions. Neuropharmacology 122:85-99
Varodayan, Florence P; de Guglielmo, Giordano; Logrip, Marian L et al. (2017) Alcohol Dependence Disrupts Amygdalar L-Type Voltage-Gated Calcium Channel Mechanisms. J Neurosci 37:4593-4603

Showing the most recent 10 out of 184 publications