The Administrative Core will provide the scientific leadership and administrative support for this Alcohol Research Center (ARC). It will direct the scientific review of and start and termination of approved pilot projects, and the funding of new pilot projects (if unspent funds become available) after appropriate review. It will provide a central source of statistical expertise, and will provide guidance in the interpretation of the microarray data provided from the Genomics and Molecular Biology Core. It will monitor the progress of all research components and core activities. In all these matters, the advice of a Program Advisory Committee consisting of extramural and intramural scientists will be sought. It will serve the investigators in fiscal planning and procurement and personnel management. It will authorize and provide funds for travel and pay for publishing costs. It will provide leadership in organizing seminars, conferences, and workshops and in dissemination of new research knowledge to the academic and lay communities. It will seek to develop new collaborations within the School and University;it will also foster collaborative research ventures between the IARC and other ARCs and investigators in this country and abroad. It will support the Translational Research and Science Education component as it develops educational programs aimed at health care providers, and outreach activities for members of the judiciary and local alcohol treatment providers, and will add to the capabilities and value of the Center's web site. It will participate in the recruitment and career development of a junior alcohol reserachers, and seek to attract promising individuals into the field.
Alcohol abuse and alcoholism are major public health issues. The research carried out by the investigators in the Indiana ARC will help us better understand the neurobiological basis of alcohol preference and craving, the role of genes implicated in the risk of alcoholism on responses to alcohol, and the mechanisms that are responsible for the fetal alcohol syndrome. It will take a leadership role in development of educational materials related to the science of alcohol addiction for health care workers (nurses, social workers, and physicians) as well as attorneys and judges.
|Wardell, Jeffrey D; Ramchandani, Vijay A; Hendershot, Christian S (2016) Drinking Motives Predict Subjective Effects of Alcohol and Alcohol Wanting and Liking During Laboratory Alcohol Administration: A Mediated Pathway Analysis. Alcohol Clin Exp Res 40:2190-2198|
|McClintick, Jeanette N; McBride, William J; Bell, Richard L et al. (2016) Gene Expression Changes in Glutamate and GABA-A Receptors, Neuropeptides, Ion Channels, and Cholesterol Synthesis in the Periaqueductal Gray Following Binge-Like Alcohol Drinking by Adolescent Alcohol-Preferring (P) Rats. Alcohol Clin Exp Res 40:955-68|
|Yoder, Karmen K; Albrecht, Daniel S; Dzemidzic, Mario et al. (2016) Differences in IV alcohol-induced dopamine release in the ventral striatum of social drinkers and nontreatment-seeking alcoholics. Drug Alcohol Depend 160:163-9|
|Bell, R L; Hauser, S; Rodd, Z A et al. (2016) A Genetic Animal Model of Alcoholism for Screening Medications to Treat Addiction. Int Rev Neurobiol 126:179-261|
|Sari, Youssef; Toalston, Jamie E; Rao, P S S et al. (2016) Effects of ceftriaxone on ethanol, nicotine or sucrose intake by alcohol-preferring (P) rats and its association with GLT-1 expression. Neuroscience 326:117-25|
|Ding, Zheng-Ming; Ingraham, Cynthia M; Rodd, Zachary A et al. (2016) Alcohol drinking increases the dopamine-stimulating effects of ethanol and reduces D2 auto-receptor and group II metabotropic glutamate receptor function within the posterior ventral tegmental area of alcohol preferring (P) rats. Neuropharmacology 109:41-8|
|O'Tousa, David S; Grahame, Nicholas J (2016) Long-Term Alcohol Drinking Reduces the Efficacy of Forced Abstinence and Conditioned Taste Aversion in Crossed High-Alcohol-Preferring Mice. Alcohol Clin Exp Res 40:1577-85|
|King, Andrea C; Hasin, Deborah; O'Connor, Sean J et al. (2016) A Prospective 5-Year Re-examination of Alcohol Response in Heavy Drinkers Progressing in Alcohol Use Disorder. Biol Psychiatry 79:489-98|
|Beckwith, Steven Wesley; Czachowski, Cristine Lynn (2016) Alcohol-Preferring P Rats Exhibit Elevated Motor Impulsivity Concomitant with Operant Responding andÂ Self-Administration of Alcohol. Alcohol Clin Exp Res 40:1100-10|
|Qiu, Bin; Bell, Richard L; Cao, Yong et al. (2016) Npy deletion in an alcohol non-preferring rat model elicits differential effects on alcohol consumption and body weight. J Genet Genomics 43:421-30|
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