The primary goal of the proposed research is to advance translation of alcohol and HIV/AIDS prevention research into a rural Southern community, among a highly disparate group - African American Blacks. HIV/AIDS continues to be a public health concern in rural America. The South is disproportionally affected by rural HIV/AIDS cases, particularly among African Americans. In addition to being disproportionately affected by HIV, the rural South is also experiencing surges of increased alcohol and drug abuse. Unfortunately, literature to guide HIV and other sexually transmitted infection (STI) prevention outreach in rural areas remains limited.
The specific aims of the proposed study are: 1) to gain an in-depth understanding of HIV risk and protective behaviors among African American alcohol using social networks within rural communities;2) to adapt, implement, and evaluate a community-level evidenced-based HIV intervention, the Community Popular Opinion Leader (C-POL) targeting this population;3) to lay the ground-work for future adoption and implementation of community-level HIV prevention to alcohol using networks throughout rural Louisiana. Rural Louisiana is an ideal location for such prevention activities. Proposed activities will take place in the rural region located directly between the New Orleans and Baton Rouge Metropolitan areas. These two cities were ranked respectively as the 2nd and 3rd highest metropolitan areas in AIDS case rates during 2007. To conduct the research, we will partner with a local rural community-based organization (CBO), the Southeast Louisiana Area Health Education Center (SELAHEC), the Louisiana Office of Public Health's (OPH) HIV/AIDS Program, and a local Federally Qualified Health Center (FQHC) in the region. The C-POL intervention is ideal for the proposed target population and setting, given its efficiency, use of an empirically-tested and effective model, emphasis on community empowerment, ability to address other pertinent issues, and broad adaptability. The strengths of the proposed study are in its target population, adaptation of a community- and evidence-based HIV intervention, and unique partnerships aimed at reducing HIV infection, increasing HIV testing, and decreasing stigma among rural African Americans.

Public Health Relevance

The proposed project builds on our previous Alcohol Research Center's translational component and fits nicely within the Trans-NIH Plan for HIV-Research in the Behavioral/Social Science Area of Emphasis as we form a unique partnership to adapt the active ingredients of an efficacious, theory based intervention. Overall, the study findings may contribute to healthier people as well as healthier environments and a reduction in HIV/AIDS health disparities among rural African Americans.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Comprehensive Center (P60)
Project #
5P60AA009803-21
Application #
8577113
Study Section
Special Emphasis Panel (ZAA1-DD)
Project Start
Project End
Budget Start
2013-12-01
Budget End
2014-11-30
Support Year
21
Fiscal Year
2014
Total Cost
$89,499
Indirect Cost
$21,943
Name
Louisiana State Univ Hsc New Orleans
Department
Type
DUNS #
782627814
City
New Orleans
State
LA
Country
United States
Zip Code
70112
Choi, Sun-Mi; McAleer, Jeremy P; Trevejo-Nunez, Giraldina et al. (2014) Acute alcohol intoxication impairs methicillin-resistant Staphylococcus aureus clearance in the lung by impeding epithelial production of Reg3?. Infect Immun 82:1402-7
Siggins, Robert W; Molina, Patricia; Zhang, Ping et al. (2014) Dysregulation of myelopoiesis by chronic alcohol administration during early SIV infection of rhesus macaques. Alcohol Clin Exp Res 38:1993-2000
Brown, Armand O; Mann, Beth; Gao, Geli et al. (2014) Streptococcus pneumoniae translocates into the myocardium and forms unique microlesions that disrupt cardiac function. PLoS Pathog 10:e1004383
Dodd, Tracy; Simon, Liz; LeCapitaine, Nicole J et al. (2014) Chronic binge alcohol administration accentuates expression of pro-fibrotic and inflammatory genes in the skeletal muscle of simian immunodeficiency virus-infected macaques. Alcohol Clin Exp Res 38:2697-706
Loganantharaj, Nisha; Nichols, Whitney A; Bagby, Gregory J et al. (2014) The effects of chronic binge alcohol on the genital microenvironment of simian immunodeficiency virus-infected female rhesus macaques. AIDS Res Hum Retroviruses 30:783-91
Ghare, Smita S; Joshi-Barve, Swati; Moghe, Akshata et al. (2014) Coordinated histone H3 methylation and acetylation regulate physiologic and pathologic fas ligand gene expression in human CD4+ T cells. J Immunol 193:412-21
Molina, Patricia E (2014) Alcohol binging exacerbates adipose tissue inflammation following burn injury. Alcohol Clin Exp Res 38:33-5
Deshmukh, Hitesh S; Liu, Yuhong; Menkiti, Ogechukwu R et al. (2014) The microbiota regulates neutrophil homeostasis and host resistance to Escherichia coli K1 sepsis in neonatal mice. Nat Med 20:524-30
Simon, Liz; LeCapitaine, Nicole; Berner, Paul et al. (2014) Chronic binge alcohol consumption alters myogenic gene expression and reduces in vitro myogenic differentiation potential of myoblasts from rhesus macaques. Am J Physiol Regul Integr Comp Physiol 306:R837-44
El Hajj, Elia C; El Hajj, Milad C; Voloshenyuk, Tetyana G et al. (2014) Alcohol modulation of cardiac matrix metalloproteinases (MMPs) and tissue inhibitors of MMPs favors collagen accumulation. Alcohol Clin Exp Res 38:448-56

Showing the most recent 10 out of 37 publications