The Administrative Core (Component #1) performs the centralized administrative functions for all 5 Research Components (#5 - #9) and the Pilot Projects (Component #10). It also coordinates the activities of the Support Cores (Components #2 and #3), and the Education and Outreach Component (#4). Scientific oversight Is provided by the Scientific Advisory Board, and executive decisions regarding PARC activities are made by the Executive Committee. The Executive Committee will set and continuously evaluate progress toward general scientific research directions, and will oversee quality control mechanisms in all areas of Center activity. Oversight also will be provided over animal production and the centralized facilities for producing alcohol dependence and assessing withdrawal, drinking and impulsivity. It will oversee genomics, bioinformatics and data sharing, biostatistical analyses, and training and educational enrichment and outreach activities. There are two lines of administrative responsibility within the Administrative Core. The general administrative coordination of all Center activities and the Center's budget will be supervised by Dr. Crabbe, the Center Director. The coordination of and future planning for scientific directions will be supervised by Dr. Hitzemann, the Scientific Director, who will act as Director In Dr. Crabbe's absence.
Administrative activities are designed to produce coordinated advances on all research fronts, facilitating discovery. Through the Outreach activities of the Center, discoveries are disseminated to the general public.
|Greenberg, Gian D; Phillips, Tamara J; Crabbe, John C (2016) Effects of acute alcohol withdrawal on nest building in mice selectively bred for alcohol withdrawal severity. Physiol Behav 165:257-66|
|Shi, Xiao; Walter, Nicole A R; Harkness, John H et al. (2016) Genetic Polymorphisms Affect Mouse and Human Trace Amine-Associated Receptor 1 Function. PLoS One 11:e0152581|
|Smith, Monique L; Hostetler, Caroline M; Heinricher, Mary M et al. (2016) Social transfer of pain in mice. Sci Adv 2:e1600855|
|Siciliano, Cody A; Calipari, Erin S; Yorgason, Jordan T et al. (2016) Chronic ethanol self-administration in macaques shifts dopamine feedback inhibition to predominantly D2 receptors in nucleus accumbens core. Drug Alcohol Depend 158:159-63|
|Barkley-Levenson, Amanda M; Ryabinin, Andrey E; Crabbe, John C (2016) Neuropeptide Y response to alcohol is altered in nucleus accumbens of mice selectively bred for drinking to intoxication. Behav Brain Res 302:160-70|
|Shabani, Shkelzen; Houlton, Sydney K; Hellmuth, Laura et al. (2016) A Mouse Model for Binge-Level Methamphetamine Use. Front Neurosci 10:493|
|Chesler, Elissa J; Gatti, Daniel M; Morgan, Andrew P et al. (2016) Diversity Outbred Mice at 21: Maintaining Allelic Variation in the Face of Selection. G3 (Bethesda) 6:3893-3902|
|Siciliano, Cody A; Calipari, Erin S; Yorgason, Jordan T et al. (2016) Increased presynaptic regulation of dopamine neurotransmission in the nucleus accumbens core following chronic ethanol self-administration in female macaques. Psychopharmacology (Berl) 233:1435-43|
|Crabbe, John C; Schlumbohm, Jason P; Hack, Wyatt et al. (2016) Fear conditioning in mouse lines genetically selected for binge-like ethanol drinking. Alcohol 52:25-32|
|Smith, M L; Li, J; Cote, D M et al. (2016) Effects of isoflurane and ethanol administration on c-Fos immunoreactivity in mice. Neuroscience 316:337-43|
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