The administrative core of this alcohol research center: MOLECULAR AND CELLULAR PATHOGENESIS IN ALCOHOLISM is organized to promote research and education regarding the pathological effects of repeated ethanol exposure at the molecular, cellular and circuit levels. In this renewal, we build upon the strengths of our Center by extending our understanding of ethanol pathology mediated by cytokine, GABA, glutamate, corticotropin releasing factor and dopamine signaling and delineating the circuitry involved in these adaptations.
The specific aims of the Administrative Core are to provide scientific inspiration and administrative leadership for the Alcohol Research Center, monitor and enhance interaction among the research components, optimize synergy and sharing of resources and services among the components, organize seminars, conferences, and workshops to stimulate exchange of scientific information among the Center faculty and staff. This core is also responsible for administration of the pilot project program. Further, it will work to stimulate new alcohol research programs at UNC, disseminate new research knowledge to academic, student, health professional and lay communities. The Administrative core in the current funded period has been involved in community outreach activities designed to improve awareness, prevention, and treatment of alcoholism and support regional and national research initiatives aimed at improving knowledge, prevention and treatment of alcoholism. These activities complement the aims of the Research Translation Information Dissemination Component of this comprehensive Alcohol Research Center. In addition, the Administrative Core oversees all budgetary issues, appropriate allocation of funds as well as preparation of progress reports and renewal of the ARC.

Public Health Relevance

Alcoholism is a major public health problem of unknown etiology. This ARC is devoted to understanding the mechanisms of pathology associated with alcoholism and alcohol abuse. The field has been hampered by lack of understanding of the brain circuitry that underiies alcohol-induced pathology. We propose a comprehensive and integrated investigation of molecular, cellular and circuit pathology in alcoholism using forefront strategies.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Comprehensive Center (P60)
Project #
5P60AA011605-17
Application #
8593202
Study Section
Special Emphasis Panel (ZAA1-GG)
Project Start
Project End
Budget Start
2013-12-01
Budget End
2014-11-30
Support Year
17
Fiscal Year
2014
Total Cost
$120,332
Indirect Cost
$41,167
Name
University of North Carolina Chapel Hill
Department
Type
DUNS #
608195277
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Vetreno, Ryan P; Lawrimore, Colleen J; Rowsey, Pamela J et al. (2018) Persistent Adult Neuroimmune Activation and Loss of Hippocampal Neurogenesis Following Adolescent Ethanol Exposure: Blockade by Exercise and the Anti-inflammatory Drug Indomethacin. Front Neurosci 12:200
Broadwater, Margaret A; Lee, Sung-Ho; Yu, Yang et al. (2018) Adolescent alcohol exposure decreases frontostriatal resting-state functional connectivity in adulthood. Addict Biol 23:810-823
Fiorenza, Amanda M; Shnitko, Tatiana A; Sullivan, Kaitlin M et al. (2018) Ethanol Exposure History and Alcoholic Reward Differentially Alter Dopamine Release in the Nucleus Accumbens to a Reward-Predictive Cue. Alcohol Clin Exp Res 42:1051-1061
Hwa, Lara S; Neira, Sofia; Pina, Melanie M et al. (2018) Predator odor increases avoidance and glutamatergic synaptic transmission in the prelimbic cortex via corticotropin-releasing factor receptor 1 signaling. Neuropsychopharmacology :
Faccidomo, Sara; Swaim, Katarina S; Saunders, Briana L et al. (2018) Mining the nucleus accumbens proteome for novel targets of alcohol self-administration in male C57BL/6J mice. Psychopharmacology (Berl) 235:1681-1696
Bohnsack, John Peyton; Hughes, Benjamin A; O'Buckley, Todd K et al. (2018) Histone deacetylases mediate GABAA receptor expression, physiology, and behavioral maladaptations in rat models of alcohol dependence. Neuropsychopharmacology 43:1518-1529
Coleman Jr, Leon G; Zou, Jian; Qin, Liya et al. (2018) HMGB1/IL-1? complexes regulate neuroimmune responses in alcoholism. Brain Behav Immun 72:61-77
Fish, E W; Wieczorek, L A; Rumple, A et al. (2018) The enduring impact of neurulation stage alcohol exposure: A combined behavioral and structural neuroimaging study in adult male and female C57BL/6J mice. Behav Brain Res 338:173-184
Beattie, Matthew C; Reguyal, Christopher S; Porcu, Patrizia et al. (2018) Neuroactive Steroid (3?,5?)3-hydroxypregnan-20-one (3?,5?-THP) and Pro-inflammatory Cytokine MCP-1 Levels in Hippocampus CA1 are Correlated with Voluntary Ethanol Consumption in Cynomolgus Monkey. Alcohol Clin Exp Res 42:12-20
Mazzone, C M; Pati, D; Michaelides, M et al. (2018) Acute engagement of Gq-mediated signaling in the bed nucleus of the stria terminalis induces anxiety-like behavior. Mol Psychiatry 23:143-153

Showing the most recent 10 out of 227 publications