MOLECULAR EPIDEMIOLOGY OF ALCOHOLISM AND COMORBID DISORDERS This MARC research project, project 5, seeks to build upon gene-discovery projects such as COGA (Collaborative Study on the Genetics of Alcoholism: PI, Porjesz) and similar projects (e.g. Pis Hill, Kendler) which are studying treatment-ascertained alcoholics and their relatives, and the MARC-affiliated Alcohol-QTL IRPG consortium (Pis Heath, Martin, Madden, Todd), which is studying community-ascertained alcoholics and heavy smokers and their adult relatives, by incorporating a molecular genetic component into 5 prospective longitudinal studies (Pis Anokhin, Bucholz, Chassin, Heath, Sher: ABCHS Cohorts) spanning the age-range from early adolescence into young adulthood. In addition to completing DNA collection on the Heath cohort (years 1-2), this research project will conduct genotyping for a limited number of candidate genes (years 1-2);and DNA array genetic association analysis (years 3-5). We focus on a limited number of candidate phenotypes where prospective data are expected to be informative for understanding the etiology of alcoholism. The selection of the first candidate phenotypes and candidate genes is guided by the MARC focus on the roles of overlapping mechanisms of behavioral under-control, negative affect regulation and pharmacologic vulnerability in the etiology of alcohol use disorders (AUDs), emphasizing AUD phenotypes associated with (a) externalizing symptoms, (b) tolerance and quantitative consumption indices, (c) cooccurrence with tobacco dependence, and (d) negative affect. The second set of candidate genes will be selected from replicated genome-wide association (GWA) study results from COGA, Australian IRPG and other studies.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Comprehensive Center (P60)
Project #
5P60AA011998-14
Application #
8375814
Study Section
Special Emphasis Panel (ZAA1-BB)
Project Start
Project End
Budget Start
2012-06-01
Budget End
2013-05-31
Support Year
14
Fiscal Year
2012
Total Cost
$313,183
Indirect Cost
$96,731
Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Acevedo, María Belén; Eagon, J Christopher; Bartholow, Bruce D et al. (2017) Sleeve gastrectomy surgery: When 2 alcoholic drinks are converted to 4. Surg Obes Relat Dis :
Otto, Jacqueline M; Gizer, Ian R; Deak, Joseph D et al. (2017) A cis-eQTL in OPRM1 is Associated with Subjective Response to Alcohol and Alcohol Use. Alcohol Clin Exp Res 41:929-938
Von Gunten, Curtis D; Volpert-Esmond, Hannah I; Bartholow, Bruce D (2017) Temporal dynamics of reactive cognitive control as revealed by event-related brain potentials. Psychophysiology :
Agrawal, A; Chou, Y-L; Carey, C E et al. (2017) Genome-wide association study identifies a novel locus for cannabis dependence. Mol Psychiatry :
Micalizzi, Lauren; Marceau, Kristine; Brick, Leslie A et al. (2017) Inhibitory Control in Siblings Discordant for Exposure to Maternal Smoking During Pregnancy. Dev Psychol :
Carpenter, Ryan W; Trela, Constantine J; Lane, Sean P et al. (2017) Elevated rate of alcohol consumption in borderline personality disorder patients in daily life. Psychopharmacology (Berl) 234:3395-3406
Martins, Jorge S; Bartholow, Bruce D; Cooper, M Lynne et al. (2017) Associations Between Executive Functioning, Affect-Regulation Drinking Motives, and Alcohol Use and Problems. Psychol Addict Behav :
Sadler, Brooke E; Grant, Julia D; Duncan, Alexis E et al. (2017) The Influence of Paternal Separation, Paternal History of Alcohol Use Disorder Risk, and Early Substance Use on Offspring Educational Attainment by Young Adulthood. J Stud Alcohol Drugs 78:426-434
Hone, Liana S E; Bartholow, Bruce D; Piasecki, Thomas M et al. (2017) Women's Alcohol Sensitivity Predicts Alcohol-Related Regretted Sex. Alcohol Clin Exp Res 41:1630-1636
Korucuoglu, Ozlem; Sher, Kenneth J; Wood, Phillip K et al. (2017) Acute alcohol effects on set-shifting and its moderation by baseline individual differences: a latent variable analysis. Addiction 112:442-453

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