MOLECULAR EPIDEMIOLOGY OF ALCOHOLISM AND COMORBID DISORDERS This MARC research project, project 5, seeks to build upon gene-discovery projects such as COGA (Collaborative Study on the Genetics of Alcoholism: PI, Porjesz) and similar projects (e.g. Pis Hill, Kendler) which are studying treatment-ascertained alcoholics and their relatives, and the MARC-affiliated Alcohol-QTL IRPG consortium (Pis Heath, Martin, Madden, Todd), which is studying community-ascertained alcoholics and heavy smokers and their adult relatives, by incorporating a molecular genetic component into 5 prospective longitudinal studies (Pis Anokhin, Bucholz, Chassin, Heath, Sher: ABCHS Cohorts) spanning the age-range from early adolescence into young adulthood. In addition to completing DNA collection on the Heath cohort (years 1-2), this research project will conduct genotyping for a limited number of candidate genes (years 1-2);and DNA array genetic association analysis (years 3-5). We focus on a limited number of candidate phenotypes where prospective data are expected to be informative for understanding the etiology of alcoholism. The selection of the first candidate phenotypes and candidate genes is guided by the MARC focus on the roles of overlapping mechanisms of behavioral under-control, negative affect regulation and pharmacologic vulnerability in the etiology of alcohol use disorders (AUDs), emphasizing AUD phenotypes associated with (a) externalizing symptoms, (b) tolerance and quantitative consumption indices, (c) cooccurrence with tobacco dependence, and (d) negative affect. The second set of candidate genes will be selected from replicated genome-wide association (GWA) study results from COGA, Australian IRPG and other studies.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Comprehensive Center (P60)
Project #
5P60AA011998-14
Application #
8375814
Study Section
Special Emphasis Panel (ZAA1-BB)
Project Start
Project End
Budget Start
2012-06-01
Budget End
2013-05-31
Support Year
14
Fiscal Year
2012
Total Cost
$313,183
Indirect Cost
$96,731
Name
Washington University
Department
Type
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
van den Berg, Stéphanie M; de Moor, Marleen H M; Verweij, Karin J H et al. (2016) Meta-analysis of Genome-Wide Association Studies for Extraversion: Findings from the Genetics of Personality Consortium. Behav Genet 46:170-82
Schwantes-An, Tae-Hwi; Zhang, Juan; Chen, Li-Shiun et al. (2016) Association of the OPRM1 Variant rs1799971 (A118G) with Non-Specific Liability to Substance Dependence in a Collaborative de novo Meta-Analysis of European-Ancestry Cohorts. Behav Genet 46:151-69
Werner, K B; McCutcheon, V V; Challa, M et al. (2016) The association between childhood maltreatment, psychopathology, and adult sexual victimization in men and women: results from three independent samples. Psychol Med 46:563-73
Bailey, Kira; Bartholow, Bruce D (2016) Alcohol words elicit reactive cognitive control in low-sensitivity drinkers. Psychophysiology 53:1751-1759
Fleming, Kimberly A; Bartholow, Bruce D; Hilgard, Joseph et al. (2016) The Alcohol Sensitivity Questionnaire: Evidence for Construct Validity. Alcohol Clin Exp Res 40:880-8
Elam, Kit K; Wang, Frances L; Bountress, Kaitlin et al. (2016) Predicting substance use in emerging adulthood: A genetically informed study of developmental transactions between impulsivity and family conflict. Dev Psychopathol 28:673-88
Fleming, Kimberly A; Heintzelman, Samantha J; Bartholow, Bruce D (2016) Specifying Associations Between Conscientiousness and Executive Functioning: Mental Set Shifting, Not Prepotent Response Inhibition or Working Memory Updating. J Pers 84:348-60
Werner, K B; McCutcheon, V V; Agrawal, A et al. (2016) The association of specific traumatic experiences with cannabis initiation and transition to problem use: Differences between African-American and European-American women. Drug Alcohol Depend 162:162-9
Trull, Timothy J; Wycoff, Andrea M; Lane, Sean P et al. (2016) Cannabis and alcohol use, affect and impulsivity in psychiatric out-patients' daily lives. Addiction 111:2052-2059
Bailey, Kira; Amlung, Michael T; Morris, David H et al. (2016) Separate and joint effects of alcohol and caffeine on conflict monitoring and adaptation. Psychopharmacology (Berl) 233:1245-55

Showing the most recent 10 out of 187 publications