This P60 application is the competing renewal application for the multi-site Multi-disciplinary Alcoholism Research Center (MARC). The broad focus of our research is the multi-level investigation (from lifetime diagnostic to real-time ecological) of the etiology and course of alcohol use disorders and associated comorbidity in community (rather than clinically ascertained) samples, with a particular focus on the period of young adulthood. The MARC is organized as: (1) an Administrative Core, which is responsible for coordinating MARC-based research projects with each other, and with our broader R01-supported portfolio of genetic, prospective high-risk and human experimental and ecological studies, (2) a Science Resource Core for support of (i) sample ascertainment and tracking, (ii) data-base management for our phenotypic, genotypic and environmental exposure data, and (iii) assessment coordination, (3) a Pilot Project core to facilitate the development of junior faculty as new investigators;(4) an Outreach Core, which extends our outreach through a new 2-week annual Alcohol Research Training Summer School, targeting undergraduates, to increase, nationally, the diversity of the pool of future alcoholism researchers;(5) four research projects. New Project 8 proposes 3 alcohol challenge experiments to characterize acute alcohol effects on executive cognitive functioning on the ascending versus descending limbs of the BAG curve. New Project 7 proposes a new wave of data collection for our OZ-ALC GWAS sample of N=3600, 50% with alcohol dependence history, derived from studies of the Australian Twin Panel, to update information about drinking patterns and ADD, and retrospective data about early childhood exposures (especially maltreatment). Project 6 extends our real-time Ecological Momentary Assessment study of the relationships between negative and positive affect, initiation of drinking episodes, and positive and negative reinforcement by alcohol, by focusing on a patient group characterized by severe affective dysregulation and impulsivity (Borderline Personality Disorder), who are known to have high risk of alcohol dependence. Project 5 adds a molecular epidemiology component to the prospective ABCHS cohort studies, R01-funded projects led by Anokhin, Bucholz, Chassin, Heath and Sher, to inform in prospective samples genetic associations, and GxE effects, identified in Project 7 and in other ongoing GWAS and gene-mapping studies.

National Institute of Health (NIH)
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Comprehensive Center (P60)
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Study Section
Special Emphasis Panel (ZAA1-BB (90))
Program Officer
Parsian, Abbas
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Washington University
Schools of Medicine
Saint Louis
United States
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Coffee and Caffeine Genetics Consortium; Cornelis, M C; Byrne, E M et al. (2015) Genome-wide meta-analysis identifies six novel loci associated with habitual coffee consumption. Mol Psychiatry 20:647-56
Santangelo, Philip; Reinhard, Iris; Mussgay, Lutz et al. (2014) Specificity of affective instability in patients with borderline personality disorder compared to posttraumatic stress disorder, bulimia nervosa, and healthy controls. J Abnorm Psychol 123:258-72
Pedersen, William C; Vasquez, Eduardo A; Bartholow, Bruce D et al. (2014) Are You Insulting Me? Exposure to Alcohol Primes Increases Aggression Following Ambiguous Provocation. Pers Soc Psychol Bull 40:1037-1049
Plunk, Andrew D; Syed-Mohammed, Husham; Cavazos-Rehg, Patricia et al. (2014) Alcohol consumption, heavy drinking, and mortality: rethinking the j-shaped curve. Alcohol Clin Exp Res 38:471-8
Zuo, Lingjun; Wang, Kesheng; Wang, Guilin et al. (2014) Common PTP4A1-PHF3-EYS variants are specific for alcohol dependence. Am J Addict 23:411-4
Heath, Andrew C; Waldron, Mary C; Martin, Nicholas G et al. (2014) Human mate selection and addiction: a conceptual critique. Behav Genet 44:419-26
Sacco, Paul; Bucholz, Kathleen K; Harrington, Donna (2014) Gender differences in stressful life events, social support, perceived stress, and alcohol use among older adults: results from a National Survey. Subst Use Misuse 49:456-65
van den Berg, St├ęphanie M; de Moor, Marleen H M; McGue, Matt et al. (2014) Harmonization of Neuroticism and Extraversion phenotypes across inventories and cohorts in the Genetics of Personality Consortium: an application of Item Response Theory. Behav Genet 44:295-313
Haeny, Angela M; Littlefield, Andrew K; Sher, Kenneth J (2014) False negatives in the assessment of lifetime alcohol use disorders: a serious but unappreciated problem. J Stud Alcohol Drugs 75:530-5
Waldron, Mary; Vaughan, Ellen L; Bucholz, Kathleen K et al. (2014) Risks for early substance involvement associated with parental alcoholism and parental separation in an adolescent female cohort. Drug Alcohol Depend 138:130-6

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