This P60 application is the competing renewal application for the multi-site Multi-disciplinary Alcoholism Research Center (MARC). The broad focus of our research is the multi-level investigation (from lifetime diagnostic to real-time ecological) of the etiology and course of alcohol use disorders and associated comorbidity in community (rather than clinically ascertained) samples, with a particular focus on the period of young adulthood. The MARC is organized as: (1) an Administrative Core, which is responsible for coordinating MARC-based research projects with each other, and with our broader R01-supported portfolio of genetic, prospective high-risk and human experimental and ecological studies, (2) a Science Resource Core for support of (i) sample ascertainment and tracking, (ii) data-base management for our phenotypic, genotypic and environmental exposure data, and (iii) assessment coordination, (3) a Pilot Project core to facilitate the development of junior faculty as new investigators;(4) an Outreach Core, which extends our outreach through a new 2-week annual Alcohol Research Training Summer School, targeting undergraduates, to increase, nationally, the diversity of the pool of future alcoholism researchers;(5) four research projects. New Project 8 proposes 3 alcohol challenge experiments to characterize acute alcohol effects on executive cognitive functioning on the ascending versus descending limbs of the BAG curve. New Project 7 proposes a new wave of data collection for our OZ-ALC GWAS sample of N=3600, 50% with alcohol dependence history, derived from studies of the Australian Twin Panel, to update information about drinking patterns and ADD, and retrospective data about early childhood exposures (especially maltreatment). Project 6 extends our real-time Ecological Momentary Assessment study of the relationships between negative and positive affect, initiation of drinking episodes, and positive and negative reinforcement by alcohol, by focusing on a patient group characterized by severe affective dysregulation and impulsivity (Borderline Personality Disorder), who are known to have high risk of alcohol dependence. Project 5 adds a molecular epidemiology component to the prospective ABCHS cohort studies, R01-funded projects led by Anokhin, Bucholz, Chassin, Heath and Sher, to inform in prospective samples genetic associations, and GxE effects, identified in Project 7 and in other ongoing GWAS and gene-mapping studies.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Comprehensive Center (P60)
Project #
5P60AA011998-15
Application #
8475406
Study Section
Special Emphasis Panel (ZAA1-BB (90))
Program Officer
Parsian, Abbas
Project Start
1999-05-11
Project End
2014-05-31
Budget Start
2013-06-01
Budget End
2014-05-31
Support Year
15
Fiscal Year
2013
Total Cost
$1,513,991
Indirect Cost
$249,140
Name
Washington University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
068552207
City
Saint Louis
State
MO
Country
United States
Zip Code
63130
Martins, Jorge S; Bartholow, Bruce D; Cooper, M Lynne et al. (2018) Associations between executive functioning, affect-regulation drinking motives, and alcohol use and problems. Psychol Addict Behav 32:16-28
Agrawal, A; Chou, Y-L; Carey, C E et al. (2018) Genome-wide association study identifies a novel locus for cannabis dependence. Mol Psychiatry 23:1293-1302
Micalizzi, Lauren; Marceau, Kristine; Brick, Leslie A et al. (2018) Inhibitory control in siblings discordant for exposure to maternal smoking during pregnancy. Dev Psychol 54:199-208
Werner, Kimberly B; Cunningham-Williams, Renee M; Sewell, Whitney et al. (2018) The Impact of Traumatic Experiences on Risky Sexual Behaviors in Black and White Young Adult Women. Womens Health Issues 28:421-429
Carpenter, Ryan W; Tragesser, Sarah L; Lane, Sean P et al. (2018) Momentary assessment of everyday physical pain in outpatients with borderline personality disorder. Personal Disord :
Bartholow, Bruce D; Fleming, Kimberly A; Wood, Phillip K et al. (2018) Alcohol effects on response inhibition: Variability across tasks and individuals. Exp Clin Psychopharmacol 26:251-267
Waldron, Mary; Watkins, Nicole K; Bucholz, Kathleen K et al. (2018) Interactive Effects of Maternal Alcohol Problems and Parental Separation on Timing of Daughter's First Drink. Alcohol Clin Exp Res 42:120-127
Acevedo, María Belén; Eagon, J Christopher; Bartholow, Bruce D et al. (2018) Sleeve gastrectomy surgery: when 2 alcoholic drinks are converted to 4. Surg Obes Relat Dis 14:277-283
Von Gunten, Curtis D; Volpert-Esmond, Hannah I; Bartholow, Bruce D (2018) Temporal dynamics of reactive cognitive control as revealed by event-related brain potentials. Psychophysiology 55:
Hepp, Johanna; Lane, Sean P; Wycoff, Andrea M et al. (2018) Interpersonal stressors and negative affect in individuals with borderline personality disorder and community adults in daily life: A replication and extension. J Abnorm Psychol 127:183-189

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