The purpose of this project is to investigate the relationship between telephone counseling that is designed to enhance an arthritis patient's participation in medical care and health status improvement.
The specific aims of the project are to: 1) develop a telephone counseling model that will increase patient involvement with their medical care, 2) carry out a randomized, controlled, clinical trial of the intervention, 3) estimate the amount of pain, physical disability, psychological disability, medical care usage, and medication usage that is changed by the intervention, 4) determine the duration of the intervention needed for a positive outcome, 5) estimate the effectiveness of the 12 months after the end of the intervention, 6) estimate the level of association between the amount of patient involvement in care, social support, and arthritis health status, and, 7) estimate the effectiveness of the intervention on specific subgroups of patients. A total of 525 rheumatoid and osteoarthritis patients from the Alabama community will participate over the 5-year period of the project. Each patient will be randomly assigned to a Telephone Counseling Group or to a Control (Placebo or Usual care) group and followed for 21 months. The study will provide important findings on the level of short-term and long-term effectiveness of telephone counseling in comparison to a placebo, the underlying causes for its effectiveness, its effects on a diverse group of arthritis patients, and its optimal duration. The results of the study will help arthritis care providers determine the utility of telephone counseling for their patients.

Project Start
Project End
Budget Start
Budget End
Support Year
15
Fiscal Year
1992
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Type
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Wu, Jianming; Xie, Fenglong; Qian, Kun et al. (2011) FAS mRNA editing in Human Systemic Lupus Erythematosus. Hum Mutat 32:1268-77
Wang, Feng; Ezell, Scharri J; Zhang, Yong et al. (2010) FBA-TPQ, a novel marine-derived compound as experimental therapy for prostate cancer. Invest New Drugs 28:234-41
Wang, Wei; Rayburn, Elizabeth R; Velu, Sadanandan E et al. (2009) In vitro and in vivo anticancer activity of novel synthetic makaluvamine analogues. Clin Cancer Res 15:3511-8
Wang, Wei; Rayburn, Elizabeth R; Zhao, Yuqing et al. (2009) Novel ginsenosides 25-OH-PPD and 25-OCH3-PPD as experimental therapy for pancreatic cancer: anticancer activity and mechanisms of action. Cancer Lett 278:241-248
Wang, Wei; Rayburn, Elizabeth R; Hang, Jie et al. (2009) Anti-lung cancer effects of novel ginsenoside 25-OCH(3)-PPD. Lung Cancer 65:306-11
Wang, Wei; Rayburn, Elizabeth R; Hao, Miao et al. (2008) Experimental therapy of prostate cancer with novel natural product anti-cancer ginsenosides. Prostate 68:809-19
Annis, Douglas S; Gunderson, Kristin A; Mosher, Deane F (2007) Immunochemical analysis of the structure of the signature domains of thrombospondin-1 and thrombospondin-2 in low calcium concentrations. J Biol Chem 282:27067-75
Rayburn, Elizabeth R; Wang, Wei; Zhang, Ruiwen et al. (2007) Experimental therapy for colon cancer: anti-cancer effects of TLR9 agonism, combination with other therapeutic modalities, and dependence upon p53. Int J Oncol 30:1511-9
Wang, Hui; Rayburn, Elizabeth R; Wang, Wei et al. (2006) Immunomodulatory oligonucleotides as novel therapy for breast cancer: pharmacokinetics, in vitro and in vivo anticancer activity, and potentiation of antibody therapy. Mol Cancer Ther 5:2106-14
Annis, D S; Murphy-Ullrich, J E; Mosher, D F (2006) Function-blocking antithrombospondin-1 monoclonal antibodies. J Thromb Haemost 4:459-68

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