The long-term objectives of this proposal are: 1) to expand education of health professionals, patients, families, and the general public; 2) to develop, implement and evaluate prototype education/epidemiology/health services research programs at a high level of scientific endeavor; and 3) to expand clinical and basic research efforts. Strong collaborative interplays in medical sociology-oriented health services research will represent an augmented focus of this Center. New proposed projects in this area include studies of 1) buffers of the arthritis-disability cascade in the old/old; and 2) caregiver well-being and physicians of impaired elders. Four developmental and feasibility projects are directed toward studies of 1) purification and cloning of a soluble form of the chondrocyte interleukin-1 receptor; 2) structural/functional domains of link protein; 3) distinctive phenotypic markers of human bone marrow mesenchymal stem cells; and 4) molecular and cellular mechanisms of decreased IgG galactosylation in rheumatoid arthritis. Core programs include a Molecular Biology DNA Sequencing Core; and an Immunohisto- chemistry Core. Administration includes administrative policy, executive, steering (operations), community advisory, and national external review committees to fully interdigitate Center/University/community interface.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Comprehensive Center (P60)
Project #
5P60AR020618-16
Application #
2078474
Study Section
Arthritis and Musculoskeletal and Skin Diseases Special Grants Review Committee (AMS)
Project Start
1978-12-01
Project End
1998-06-30
Budget Start
1994-07-01
Budget End
1995-06-30
Support Year
16
Fiscal Year
1994
Total Cost
Indirect Cost
Name
Case Western Reserve University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
Cleveland
State
OH
Country
United States
Zip Code
44106
Miwa, Hazuki E; Gerken, Thomas A; Huynh, Tru D et al. (2009) Conserved sequence in the aggrecan interglobular domain modulates cleavage by ADAMTS-4 and ADAMTS-5. Biochim Biophys Acta 1790:161-72
Atif, U; Philip, A; Aponte, J et al. (2008) Absence of association of asporin polymorphisms and osteoarthritis susceptibility in US Caucasians. Osteoarthritis Cartilage 16:1174-7
Kraus, V B; Jordan, J M; Doherty, M et al. (2007) The Genetics of Generalized Osteoarthritis (GOGO) study: study design and evaluation of osteoarthritis phenotypes. Osteoarthritis Cartilage 15:120-7
Miwa, Hazuki E; Gerken, Thomas A; Huynh, Tru D et al. (2006) Mammalian expression of full-length bovine aggrecan and link protein: formation of recombinant proteoglycan aggregates and analysis of proteolytic cleavage by ADAMTS-4 and MMP-13. Biochim Biophys Acta 1760:472-86
Holderbaum, D; Malvitz, T; Ciesielski, C J et al. (2005) A newly described hereditary cartilage debonding syndrome. Arthritis Rheum 52:3300-4
Denko, Charles W; Malemud, Charles J (2005) Role of the growth hormone/insulin-like growth factor-1 paracrine axis in rheumatic diseases. Semin Arthritis Rheum 35:24-34
Ievers-Landis, Carolyn E; Burant, Christopher; Drotar, Dennis et al. (2005) A randomized controlled trial for the primary prevention of osteoporosis among preadolescent girl scouts: 1-year outcomes of a behavioral program. J Pediatr Psychol 30:155-65
Vashishth, D (2005) Collagen glycation and its role in fracture properties of bone. J Musculoskelet Neuronal Interact 5:316
Denko, Charles W; Malemud, Charles J (2005) Serum growth hormone and insulin but not insulin-like growth factor-1 levels are elevated in patients with fibromyalgia syndrome. Rheumatol Int 25:146-51
Denko, Charles W; Malemud, Charles J (2004) Age-related changes in serum growth hormone, insulin-like growth factor-1 and somatostatin in system lupus erythematosus. BMC Musculoskelet Disord 5:37

Showing the most recent 10 out of 92 publications