The Methodology Core is a centralized resource that provides direction and support for study design, data management, programming, forms development, statistical analysis, psychometric testing, training and supervision of interviewers, and the education of post-doctoral fellows and other trainees. The Methodology Core serves MCRC investigators, fellows and other trainees within the Center's Research Base. The Core leadership, faculty and staff have a wide range of experience and expertise. The primary objectives of the Methodology Core include: ? To ensure the highest methodological rigor in the design and implementation of Center research projects; ? To provide multidisciplinary methodological support to the Center Investigators and the Research Base; ? To carry out special methodological studies designed to contribute to MCRC research programs; ? To facilitate an educational program for fellows, junior faculty and other trainees through regular consultations with the Methodology Core faculty and monthly didactic seminars led by Center faculty;and ? To facilitate multidisciplinary collaboration, brainstorming of grants and projects ideas, as well as monitoring progress of Center projects through a weekly research seminar. ? To ensure data quality and protection of patient privacy in data management The Methodology Core is a key resource for ensuring the coupling of innovative ideas with rigorous study designs, methods development, appropriate data gathering, compliance with data safety and monitoring and HIPAA regulations, thorough data analysis and clear reporting of findings. In sum, the Methodology Core provides the nucleus for rigorous study of rheumatic and musculoskeletal problems in the MCRC and provides methodology support to the entire Research Base.

Public Health Relevance

The Methodology Core consists of a team of statisticians and other scientists who are experts at statistics, epidemiology and other fields that are critical to the proper design and execution of research studies. The Methodology Core will ensure that the Center's projects use the most rigorous scientific methods possible.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Comprehensive Center (P60)
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Special Emphasis Panel (ZAR1-KM (M1))
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Brigham and Women's Hospital
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Ananthakrishnan, Ashwin N; Cagan, Andrew; Cai, Tianxi et al. (2016) Identification of Nonresponse to Treatment Using Narrative Data in an Electronic Health Record Inflammatory Bowel Disease Cohort. Inflamm Bowel Dis 22:151-8
Sparks, Jeffrey A; Karlson, Elizabeth W (2016) The Roles of Cigarette Smoking and the Lung in the Transitions Between Phases of Preclinical Rheumatoid Arthritis. Curr Rheumatol Rep 18:15
Kim, Seoyoung C; Kim, Dae Hyun; Mogun, Helen et al. (2016) Impact of the U.S. Food and Drug Administration's Safety-Related Announcements on the Use of Bisphosphonates After Hip Fracture. J Bone Miner Res 31:1536-40
Sparks, Jeffrey A; Chang, Shun-Chiao; Deane, Kevin D et al. (2016) Associations of Smoking and Age With Inflammatory Joint Signs Among Unaffected First-Degree Relatives of Rheumatoid Arthritis Patients: Results From Studies of the Etiology of Rheumatoid Arthritis. Arthritis Rheumatol 68:1828-38
Suter, Lisa G; Smith, Savannah R; Katz, Jeffrey N et al. (2016) Projecting Lifetime Risk of Symptomatic Knee Osteoarthritis and Total Knee Replacement in Individuals Sustaining a Complete Anterior Cruciate Ligament Tear in Early Adulthood. Arthritis Care Res (Hoboken) :
Solomon, Daniel H; Lee, Sara B; Zak, Agnes et al. (2016) Implementation of treat-to-target in rheumatoid arthritis through a Learning Collaborative: Rationale and design of the TRACTION trial. Semin Arthritis Rheum 46:81-7
Deshpande, Bhushan R; Losina, Elena; Smith, Savannah R et al. (2016) Association of MRI findings and expert diagnosis of symptomatic meniscal tear among middle-aged and older adults with knee pain. BMC Musculoskelet Disord 17:154
Ananthakrishnan, Ashwin N; Cagan, Andrew; Cai, Tianxi et al. (2016) Statin Use Is Associated With Reduced Risk of Colorectal Cancer in Patients With Inflammatory Bowel Diseases. Clin Gastroenterol Hepatol 14:973-9
Katz, Jeffrey N; Smith, Savannah R; Yang, Heidi Y et al. (2016) The Value of History, Physical Examination, and Radiographic Findings in the Diagnosis of Symptomatic Meniscal Tear among Middle-Age Subjects with Knee Pain. Arthritis Care Res (Hoboken) :
Sparks, Jeffrey A; Chang, Shun-Chiao; Karlson, Elizabeth W (2016) Authors' reply to the letter ""Mortality due to respiratory causes in rheumatoid arthritis should be interpreted in the context of 'ever' smoking and may be due to ILD"". Arthritis Care Res (Hoboken) :

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