The Methodology Core is a centralized resource that provides direction and support for study design, data management, programming, forms development, statistical analysis, psychometric testing, training and supervision of interviewers, and the education of post-doctoral fellows and other trainees. The Methodology Core serves MCRC investigators, fellows and other trainees within the Center's Research Base. The Core leadership, faculty and staff have a wide range of experience and expertise. The primary objectives of the Methodology Core include: ? To ensure the highest methodological rigor in the design and implementation of Center research projects; ? To provide multidisciplinary methodological support to the Center Investigators and the Research Base; ? To carry out special methodological studies designed to contribute to MCRC research programs; ? To facilitate an educational program for fellows, junior faculty and other trainees through regular consultations with the Methodology Core faculty and monthly didactic seminars led by Center faculty;and ? To facilitate multidisciplinary collaboration, brainstorming of grants and projects ideas, as well as monitoring progress of Center projects through a weekly research seminar. ? To ensure data quality and protection of patient privacy in data management The Methodology Core is a key resource for ensuring the coupling of innovative ideas with rigorous study designs, methods development, appropriate data gathering, compliance with data safety and monitoring and HIPAA regulations, thorough data analysis and clear reporting of findings. In sum, the Methodology Core provides the nucleus for rigorous study of rheumatic and musculoskeletal problems in the MCRC and provides methodology support to the entire Research Base.

Public Health Relevance

The Methodology Core consists of a team of statisticians and other scientists who are experts at statistics, epidemiology and other fields that are critical to the proper design and execution of research studies. The Methodology Core will ensure that the Center's projects use the most rigorous scientific methods possible.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Comprehensive Center (P60)
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Special Emphasis Panel (ZAR1-KM (M1))
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Brigham and Women's Hospital
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Stenquist, Derek S; Elman, Scott A; Davis, Aileen M et al. (2015) Physical activity and experience of total knee replacement in patients one to four years postsurgery in the dominican republic: a qualitative study. Arthritis Care Res (Hoboken) 67:65-73
Sparks, Jeffrey A; Chen, Chia-Yen; Jiang, Xia et al. (2015) Improved performance of epidemiologic and genetic risk models for rheumatoid arthritis serologic phenotypes using family history. Ann Rheum Dis 74:1522-9
Suri, Pradeep; Hunter, David J; Boyko, Edward J et al. (2015) Physical activity and associations with computed tomography-detected lumbar zygapophyseal joint osteoarthritis. Spine J 15:42-9
Duryea, Jeffrey; Iranpour-Boroujeni, Tannaz; Collins, Jamie E et al. (2014) Local area cartilage segmentation: a semiautomated novel method of measuring cartilage loss in knee osteoarthritis. Arthritis Care Res (Hoboken) 66:1560-5
Katz, Jeffrey N; Wright, Elizabeth A; Polaris, Julian J Z et al. (2014) Prevalence and risk factors for periprosthetic fracture in older recipients of total hip replacement: a cohort study. BMC Musculoskelet Disord 15:168
Saadat, Ehsan; Martin, Scott D; Thornhill, Thomas S et al. (2014) Factors Associated With the Failure of Surgical Treatment for Femoroacetabular Impingement: Review of the Literature. Am J Sports Med 42:1487-95
Solomon, Daniel H; Patrick, Amanda R; Schousboe, John et al. (2014) The potential economic benefits of improved postfracture care: a cost-effectiveness analysis of a fracture liaison service in the US health-care system. J Bone Miner Res 29:1667-74
Maserejian, Nancy N; Fischer, Michael A; Trachtenberg, Felicia L et al. (2014) Variations among primary care physicians in exercise advice, imaging, and analgesics for musculoskeletal pain: results from a factorial experiment. Arthritis Care Res (Hoboken) 66:147-56
Al Daabil, M; Massarotti, E M; Fine, A et al. (2014) Development of SLE among "potential SLE" patients seen in consultation: long-term follow-up. Int J Clin Pract 68:1508-13
Hunter, David J; Nevitt, Michael; Losina, Elena et al. (2014) Biomarkers for osteoarthritis: current position and steps towards further validation. Best Pract Res Clin Rheumatol 28:61-71

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