RESCU (Methodology) CORE: Core unit personnel will be involved in providing each of the following four major services: project design, statistical support, Framingham/Beijing/MOST and OAI epidemiologic analyses and administration. Although these services can be considered separately for ease of presentation, they in fact represent a rich network of integrated functions that will contribute to MCRC performance in a number of ways. First, the centralization of these services helps to integrate the multiple research projects of the Center and will also serve to facilitate their administration. Second, the core service functions will provide supplemental support for projects in epidemiology and other clinical research funded through this MCRC proposal and for a number of other projects that are or will be funded from other sources. This core unit already provides substantial research support for multiple externally funded projects (e.g. three center grants, four R-01/U-01's) and will continue to do so during the next 5 year cycle. RESCU will also provide critical start up support for new projects that evolve during the grant cycle. Third, the core will provide services to other research activities including basic and clinical research projects such as those in vasculitis and scleroderma. Fourth, core funds will enable our staff to continue their consultative support of researchers at other arthritis units. The core unit arrangement will create a network of resources that extends the functions of staff beyond their specific project assignments and facilitates the efficient use of staff time. Two key features of this central resources are the shared office space of members of this support unit which leads them to frequent interactions, and the weekly staff meetings (RESCU meetings) in which ongoing and proposed research projects are critically evaluated. The continuation of this successful core unit will thus provide a set of centralized and shared resources that will enhance our productivity in an area of special Center emphasis and that will contribute to a resource in support of other arthritis investigators who need design and analysis advice.

Public Health Relevance

The RESCU core is the heart of this MCRC. Composed of a group of multidisciplinary investigators who work in close geographic proximity, this group meets together once a week to review and critique a large portfolio of diverse studies and provide methodologic assistance for research.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Comprehensive Center (P60)
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Special Emphasis Panel (ZAR1-KM)
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Boston University
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Misra, Devyani; Felson, David T; Silliman, Rebecca A et al. (2015) Knee osteoarthritis and frailty: findings from the Multicenter Osteoarthritis Study and Osteoarthritis Initiative. J Gerontol A Biol Sci Med Sci 70:339-44
Dubreuil, Maureen; Zhu, Yanyan; Zhang, Yuqing et al. (2015) Allopurinol initiation and all-cause mortality in the general population. Ann Rheum Dis 74:1368-72
Misra, D; Guermazi, A; Sieren, J P et al. (2015) CT imaging for evaluation of calcium crystal deposition in the knee: initial experience from the Multicenter Osteoarthritis (MOST) study. Osteoarthritis Cartilage 23:244-8
Haugen, Ida K; Ramachandran, Vasan S; Misra, Devyani et al. (2015) Hand osteoarthritis in relation to mortality and incidence of cardiovascular disease: data from the Framingham heart study. Ann Rheum Dis 74:74-81
Lewis, Cara L; Sahrmann, Shirley A (2015) Effect of posture on hip angles and moments during gait. Man Ther 20:176-82
Irwin, Melinda L; Cartmel, Brenda; Gross, Cary P et al. (2015) Randomized exercise trial of aromatase inhibitor-induced arthralgia in breast cancer survivors. J Clin Oncol 33:1104-11
Jutkowitz, Eric; Choi, Hyon K; Pizzi, Laura T et al. (2014) Cost-effectiveness of allopurinol and febuxostat for the management of gout. Ann Intern Med 161:617-26
White, Daniel K; Neogi, Tuhina; King, Wendy C et al. (2014) Can change in prolonged walking be inferred from a short test of gait speed among older adults who are initially well-functioning? Phys Ther 94:1285-93
Okada, Yukinori; Diogo, Dorothee; Greenberg, Jeffrey D et al. (2014) Integration of sequence data from a Consanguineous family with genetic data from an outbred population identifies PLB1 as a candidate rheumatoid arthritis risk gene. PLoS One 9:e87645
Kim, Chan; Linsenmeyer, Katherine D; Vlad, Steven C et al. (2014) Prevalence of radiographic and symptomatic hip osteoarthritis in an urban United States community: the Framingham osteoarthritis study. Arthritis Rheumatol 66:3013-7

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