The goals of the Northwestern University Multidisciplinary Clinical Research Center in Rheumatology (MCRC) are: 1) to conduct cutting-edge, nationally recognized and funded research aimed at the prevention or control of arthritis and musculoskeletal diseases and 2) to provide the academic environment that supports and enhances the interdisciplinary research of the MCRC faculty. The current projects focus on crucial issues relating to important consequences of arthritis and musculoskeletal diseases such as progression of disease (in Knee OA), and the development of the complications of osteoporosis and cardiovascular disease (in lupus), functional outcomes. The center also focuses on health care utilization, with particular emphasis on underserved minorities. The Methodology/Data Management Core and the Administrative Core support all projects. The specific objectives of this MCRC proposal are 1) to secure funding for the Center's Methodology/Data Management Core (MDMC), three clinical research projects: Potential Beneficial Role of Hip Muscles in Knee OA Progression (Project 1);SOLVABLE: Study of Lupus Vascular and Bone Longterm Endpoints (Project 2);Physical Activity, Disability, and Health Utility in Rheumatic Disease (Project 3);and one developmental/feasibility project: Role of TGF-p genetic Varients in the Pathogenesis of Scleroderma (Project 4);2) to leverage this MCRC funding to enhance the infrastructure for Rheumatology clinical research at Northwestern University, and 3) to participate in the national effort to enhance the awareness within the academic community and the community at large of the public health burden of arthritis and musculoskeletal diseases and the possible medical and public health solutions to these problems. The current MCRC at Northwestern University (NU) operates as an integrated unit to address a broad range of clinical research endeavors. The MCRC continues to unite the Medical School's Adult and Pediatric Rheumatology Divisions, other divisions in its Department of Medicine, its Department of Preventive Medicine, and the University's Institute for Healthcare Studies and the Office for Clinical Research and Training. Moreover, it fosters interactions among centers throughout the United States most notably the University of Illinois at Chicago and the University of Pittsburgh.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Comprehensive Center (P60)
Project #
5P60AR048098-10
Application #
8128397
Study Section
Special Emphasis Panel (ZAR1-MLB-G (J1))
Program Officer
Witter, James
Project Start
2002-02-15
Project End
2013-07-31
Budget Start
2011-08-01
Budget End
2013-07-31
Support Year
10
Fiscal Year
2011
Total Cost
$1,174,663
Indirect Cost
Name
Northwestern University at Chicago
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Bernatsky, S; Ramsey-Goldman, R; Petri, M et al. (2017) Breast cancer in systemic lupus. Lupus 26:311-315
Ferreira, Isabel; Croca, Sara; Raimondo, Maria Gabriella et al. (2017) Nitrated nucleosome levels and neuropsychiatric events in systemic lupus erythematosus; a multi-center retrospective case-control study. Arthritis Res Ther 19:287
Jorge, April; Lertratanakul, Apinya; Lee, Jungwha et al. (2017) Depression and Progression of Subclinical Cardiovascular Disease in Systemic Lupus Erythematosus. Arthritis Care Res (Hoboken) 69:5-11
Hanly, John G; Su, Li; Urowitz, Murray B et al. (2016) A Longitudinal Analysis of Outcomes of Lupus Nephritis in an International Inception Cohort Using a Multistate Model Approach. Arthritis Rheumatol 68:1932-44
Silverberg, Jonathan I; Song, Jing; Pinto, Daniel et al. (2016) Atopic Dermatitis Is Associated with Less Physical Activity in US Adults. J Invest Dermatol 136:1714-6
Ahn, Grace E; Chmiel, Joan S; Dunlop, Dorothy D et al. (2015) Self-reported and objectively measured physical activity in adults with systemic lupus erythematosus. Arthritis Care Res (Hoboken) 67:701-7
Arroyo-Ávila, Mariangelí; Santiago-Casas, Yesenia; McGwin Jr, Gerald et al. (2015) Clinical associations of anti-Smith antibodies in PROFILE: a multi-ethnic lupus cohort. Clin Rheumatol 34:1217-23
Dunlop, Dorothy D; Song, Jing; Arnston, Emily K et al. (2015) Sedentary time in US older adults associated with disability in activities of daily living independent of physical activity. J Phys Act Health 12:93-101
Hanly, John G; Su, Li; Urowitz, Murray B et al. (2015) Mood Disorders in Systemic Lupus Erythematosus: Results From an International Inception Cohort Study. Arthritis Rheumatol 67:1837-47
Lo, Grace H; McAlindon, Timothy E; Hawker, Gillian A et al. (2015) Symptom assessment in knee osteoarthritis needs to account for physical activity level. Arthritis Rheumatol 67:2897-904

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