Epidemiologic studies of SLE performed as early as the 1960s have noted that SLE is not only more common, but also more severe among ethnic minority populations. Subsequent studies have generated vigorous debate over the extent to which genetic, environmental or other factors account for these differences. However, most epidemiologic studies of ethnicity and SLE treat ethnic groups as homogeneous categories, thus obliterating the genetic, cultural, and socioeconomic diversity that exists within groups that could contribute to the observed differences. Using genetic ancestry rather than self-identified ethnicity provides some advantages when investigating ethnicity, genetics, and disease characteristics. This approach does not assume that racial or ethnic groups are homogeneous but rather capitalizes on genetic heterogeneity within groups to more effectively dissect the relationship between ethnicity, genetics, and disease risk. The proposed project is designed to extend our genetic epidemiologic investigations of ancestry and SLE disease characteristics and will take advantage of a novel tool, the

Public Health Relevance

Substantial prior research documents ethnic differences in SLE outcomes, with patients of non-European ancestry experiencing more severe disease and poorer outcomes overall. Recent research suggests that genetic ancestry contributes importantly to these health disparities, over and above differences that may be attributed to socioeconomic or other non-genetic factors. Elucidation of the more proximate causes of health disparities in SLE will be critically important for efforts to decrease disparities and improve outcomes for all patients. The current project will utilize unique clinical and genetic resources for these studies.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Comprehensive Center (P60)
Project #
5P60AR053308-07
Application #
8469003
Study Section
Special Emphasis Panel (ZAR1-KM)
Project Start
Project End
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
7
Fiscal Year
2013
Total Cost
$119,100
Indirect Cost
$30,294
Name
University of California San Francisco
Department
Type
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Heshin-Bekenstein, Merav; Perl, Liat; Hersh, Aimee O et al. (2018) Final adult height of patients with childhood-onset systemic lupus erythematosus: a cross sectional analysis. Pediatr Rheumatol Online J 16:30
Jafri, Kashif; Ogdie, Alexis; Qasim, Atif et al. (2018) Discordance of the Framingham cardiovascular risk score and the 2013 American College of Cardiology/American Heart Association risk score in systemic lupus erythematosus and rheumatoid arthritis. Clin Rheumatol 37:467-474
Mccormick, Natalie; Trupin, Laura; Yelin, Edward H et al. (2018) Socioeconomic Predictors of Incident Depression in Systemic Lupus Erythematosus. Arthritis Care Res (Hoboken) 70:104-113
Lanata, Cristina M; Nititham, Joanne; Taylor, Kimberly E et al. (2018) Genetic contributions to lupus nephritis in a multi-ethnic cohort of systemic lupus erythematous patients. PLoS One 13:e0199003
Azizoddin, Desiree R; Jolly, Meenakshi; Arora, Shilpa et al. (2018) Patient Reported Outcomes Predict Mortality in Lupus. Arthritis Care Res (Hoboken) :
Yelin, Edward; Trupin, Laura; Bunde, Jared et al. (2018) Poverty, Neighborhoods, Persistent Stress, and SLE Outcomes:A Qualitative Study of the Patients' Perspective. Arthritis Care Res (Hoboken) :
Wysham, Katherine D; Shoback, Dolores M; Imboden Jr, John B et al. (2018) Association of High Anti-Cyclic Citrullinated Peptide Seropositivity and Lean Mass Index With Low Bone Mineral Density in Rheumatoid Arthritis. Arthritis Care Res (Hoboken) 70:961-969
Barton, Jennifer L; Hulen, Elizabeth; Schue, Allison et al. (2018) Experience and Context Shape Patient and Clinician Goals For Treatment of Rheumatoid Arthritis: A Qualitative Study. Arthritis Care Res (Hoboken) 70:1614-1620
Yelin, Edward; Yazdany, Jinoos; Trupin, Laura (2018) Relationship Between Poverty and Mortality in Systemic Lupus Erythematosus. Arthritis Care Res (Hoboken) 70:1101-1106
Knight, Andrea M; Trupin, Laura; Katz, Patricia et al. (2018) Depression Risk in Young Adults With Juvenile- and Adult-Onset Lupus: Twelve Years of Followup. Arthritis Care Res (Hoboken) 70:475-480

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