The overall objective of the Methodology Core is to provide access to innovative methodological expertise in biostatistics, outcomes and clinical research and along with computational resources necessary for the successful completion of the proposed MCRC projects and other important projects within the research base. The Core also provides an educational resource with the intent of enhancing the methodological quality of research initiatives in musculoskeletal diseases at Dartmouth.
The specific aims are 1) to facilitate the implementation and completion of all MCRC projects and to assist investigators within the research base by providing expertise in biostatistics, research design, outcomes research, data management, and advanced computing, 2) to provide access to specialized data bases and computing resources, 3) to establish a targeted educational forum to foster methodological expertise within the existing research base by conducting research-in progress seminars in multidisciplinary clinical research with a focus on musculoskeletal disease, specialized seminars and directed research courses for pre- and post-doctoral trainees in the academic programs represented within the research base, and methodological mentorship for advanced trainees in graduate and post-graduate programs affiliated with the MCRC, 4) to provide methodological support for research review and data and safety monitoring for MCRC projects, and 5) to promote methodologic research in issues critical to the advancement of specific areas within the research base. The Core is highly integrated and closely aligned with quantitative and educational resources throughout Dartmouth, allowing for a broader representation and mutual sharing of expertise across the institution.

Public Health Relevance

Dartmouth has many experienced investigators and sources of data that will be used to improve health for individuals with musculoskeletal disease. By expanding a unique national research program in musculoskeletal diseases, this grant will train new researchers and provide high-quality resources for research projects addressing health,care in those who have broken a bone, decision making about back surgery, and the safety of new medical devices.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Comprehensive Center (P60)
Project #
5P60AR062799-02
Application #
8500220
Study Section
Special Emphasis Panel (ZAR1-KM)
Project Start
Project End
Budget Start
2013-09-01
Budget End
2014-08-31
Support Year
2
Fiscal Year
2013
Total Cost
$581,204
Indirect Cost
$225,659
Name
Dartmouth College
Department
Type
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755
Akkineni, Roopa; Tapp, Stephanie; Tosteson, Anna N A et al. (2014) Treatment of asymptomatic hyperuricemia and prevention of vascular disease: a decision analytic approach. J Rheumatol 41:739-48
Martin, Brook I; Franklin, Gary M; Deyo, Richard A et al. (2014) How do coverage policies influence practice patterns, safety, and cost of initial lumbar fusion surgery? A population-based comparison of workers' compensation systems. Spine J 14:1237-46
Martin, Brook I; Lurie, Jon D; Tosteson, Anna N A et al. (2014) Indications for spine surgery: validation of an administrative coding algorithm to classify degenerative diagnoses. Spine (Phila Pa 1976) 39:769-79
Weinstein, James N; Tosteson, Anna N A; Tosteson, Tor D et al. (2014) The SPORT value compass: do the extra costs of undergoing spine surgery produce better health benefits? Med Care 52:1055-63
Liu, Stephen K; Munson, Jeffrey C; Bell, John-Erik et al. (2014) Response letter to Herbert L. Muncie, Jr. J Am Geriatr Soc 62:998-9
Lurie, Jon D; Tosteson, Tor D; Tosteson, Anna N A et al. (2014) Surgical versus nonoperative treatment for lumbar disc herniation: eight-year results for the spine patient outcomes research trial. Spine (Phila Pa 1976) 39:3-16
Resnick, Daniel K; Tosteson, Anna N A; Groman, Rachel F et al. (2014) Setting the equation: establishing value in spine care. Spine (Phila Pa 1976) 39:S43-50
McGuire, Kevin J; Khaleel, Mohammed A; Rihn, Jeffrey A et al. (2014) The effect of high obesity on outcomes of treatment for lumbar spinal conditions: subgroup analysis of the spine patient outcomes research trial. Spine (Phila Pa 1976) 39:1975-80
Liu, Stephen K; Munson, Jeffrey C; Bell, John-Erik et al. (2013) Quality of osteoporosis care of older Medicare recipients with fragility fractures: 2006 to 2010. J Am Geriatr Soc 61:1855-62
Lurie, Jon D; Moses, Rachel A; Tosteson, Anna N A et al. (2013) Magnetic resonance imaging predictors of surgical outcome in patients with lumbar intervertebral disc herniation. Spine (Phila Pa 1976) 38:1216-25

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