This developmental project seeks to facilitate early detection of serious complications associated with new orthopedic devices. Innovative aspects of the project include validation of administratively-derived safety measures, use of FDA-approval data as a benchmark for monitoring safety, and use of readily-available population-based databases to evaluate the safety of emerging surgical devices. The project implements statistical modeling techniques that leverage medical claims data to continually assess the risks of new devices as additional data is accured on repeat surgery, infection, other complications, and death. We will demonstrate the approach by examining the experience with bone morphogenetic protein, a biological agent used as an adjuncent to spinal fusion surgery.
Timely reporting of safety data for new devices could reduce complications, help clinicians and patients make informed decisions about whether to undergo orthopaedic surgery and what types of surgical devices to use.
|Akkineni, Roopa; Tapp, Stephanie; Tosteson, Anna N A et al. (2014) Treatment of asymptomatic hyperuricemia and prevention of vascular disease: a decision analytic approach. J Rheumatol 41:739-48|
|Martin, Brook I; Franklin, Gary M; Deyo, Richard A et al. (2014) How do coverage policies influence practice patterns, safety, and cost of initial lumbar fusion surgery? A population-based comparison of workers' compensation systems. Spine J 14:1237-46|
|Martin, Brook I; Lurie, Jon D; Tosteson, Anna N A et al. (2014) Indications for spine surgery: validation of an administrative coding algorithm to classify degenerative diagnoses. Spine (Phila Pa 1976) 39:769-79|
|Weinstein, James N; Tosteson, Anna N A; Tosteson, Tor D et al. (2014) The SPORT value compass: do the extra costs of undergoing spine surgery produce better health benefits? Med Care 52:1055-63|
|Liu, Stephen K; Munson, Jeffrey C; Bell, John-Erik et al. (2014) Response letter to Herbert L. Muncie, Jr. J Am Geriatr Soc 62:998-9|
|Lurie, Jon D; Tosteson, Tor D; Tosteson, Anna N A et al. (2014) Surgical versus nonoperative treatment for lumbar disc herniation: eight-year results for the spine patient outcomes research trial. Spine (Phila Pa 1976) 39:3-16|
|Resnick, Daniel K; Tosteson, Anna N A; Groman, Rachel F et al. (2014) Setting the equation: establishing value in spine care. Spine (Phila Pa 1976) 39:S43-50|
|McGuire, Kevin J; Khaleel, Mohammed A; Rihn, Jeffrey A et al. (2014) The effect of high obesity on outcomes of treatment for lumbar spinal conditions: subgroup analysis of the spine patient outcomes research trial. Spine (Phila Pa 1976) 39:1975-80|
|Liu, Stephen K; Munson, Jeffrey C; Bell, John-Erik et al. (2013) Quality of osteoporosis care of older Medicare recipients with fragility fractures: 2006 to 2010. J Am Geriatr Soc 61:1855-62|
|Lurie, Jon D; Moses, Rachel A; Tosteson, Anna N A et al. (2013) Magnetic resonance imaging predictors of surgical outcome in patients with lumbar intervertebral disc herniation. Spine (Phila Pa 1976) 38:1216-25|
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