The UAB MCRC is a multidisciplinary program uniquely positioned to promote research related to the causes, diagnoses, treatments and improved care of patients with arthritis and musculoskeletal diseases. The MCRC builds on the capabilities of the UAB Comprehensive Arthritis, Musculoskeletal, and Autoimmunity Center (CAMAC) and its thematic workgroups (Experimental Therapeutics &Biomarkers;Neurobehavioral Medicine;Epidemiology, Prevention, &Outcomes;Genetics and Functional Genomics;Immunology, Autoimmunity &Inflammation;Bone, Cartilage and Connective Tissue). An outstanding MCRC Methodology Core is comprised of experts in biostatistics (Redden, Howard, McGwin, Aslibekyan), data management (Westfall), statistical genetics and bioinformatics (Cui, Lefkowitz, Liu) and health services research (Kilgore). All have a proven record of collaborative clinical investigation in musculoskeletal diseases. This proposal includes 3 innovative projects: 1. Genetic Determinants of Cell Type-Specific Gene Expression in RA (Brown/Bridges);2. Facilitating Treat-to-Target Strategies Using Novel Health Technology with Decision Support (Curtis);3. Adaptive Immune Responses to Gut Microbiota in Juvenile &Adult Spondyloarthritis (Elson). Projects 1 and 3 focus on populations for which there is a paucity of clinical research: (African-Americans with RA and juvenile spondyloarthritis). All projects leverage and expand upon substantial existing resources, including ongoing cohorts. The Administrative Core coordinates MCRC activities, sets the strategic agenda, facilitates interactions and collaborations, promotes scientific development, and performs evaluation of MCRC programs. Four advisory groups have been established to assist the MCRC Director and Associate Director in maximizing the strengths of the MCRC's projects, as well as in identifying and correcting weaknesses: 1. Executive Committee;2. Internal Advisory Committee;3. External Advisory Committee;4. Data Safety Monitoring Committee. The Scientific Development Program, which promotes the introduction and development of new techniques and nurtures young and new faculty in arthritis and musculoskeletal disease research, ensures the continued energy and vitality of this MCRC.

Public Health Relevance

The UAB MCRC will support innovative research to: 1. Understand regulation of gene expression in immune cells of African-Americans with RA;2. Utilize electronic tools to help rheumatologists improve outcomes of RA patients;3. Understand the role of intestinal bacteria in children and adults with spondyloarthritis. MCRC programs will teach new research methods and encourage new investigators in rheumatic diseases.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Comprehensive Center (P60)
Project #
1P60AR064172-01
Application #
8471825
Study Section
Special Emphasis Panel (ZAR1-KM (M1))
Program Officer
Wang, Yan Z
Project Start
2013-09-16
Project End
2018-07-31
Budget Start
2013-09-16
Budget End
2014-07-31
Support Year
1
Fiscal Year
2013
Total Cost
$840,879
Indirect Cost
$231,074
Name
University of Alabama Birmingham
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
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Perry, Lisa M; Winthrop, Kevin L; Curtis, Jeffrey R (2014) Vaccinations for rheumatoid arthritis. Curr Rheumatol Rep 16:431