This study investigates an expanded paradigm to improve health outcomes for adults with knee osteoarthritis (OA), through changes in the low end of the physical activity spectrum where much of the knee OA population resides. Our recent study found almost half of adults with knee OA were inactive, as defined by the U.S. Department of Health and Human Services (DHHS) (i.e., no sustained 10 minute periods of moderate-to-vigorous intensity physical activity during a week) based on objective accelerometer measurement of physical activity. It is these inactive people who will be the primary focus of this study. This study will compare health outcomes of inactive adults at baseline who become active two years later versus inactive adults at baseline who remain inactive from the Osteoarthritis Initiative (OAI) cohort of adults with or at high risk of knee OA. This proposal will utilize valuable objective longitudinal physical activity data measured on a subsample from the OAI national cohort (n=2015) to accomplish the following:
Aim 1. Evaluate if a transition from inactivity to activity is related to short-term (at 2 years) function and longterm (at 4 years) function after controlling for baseline function, descriptive factors, modifiable health factors, and non-sedentary activity.
This aim i s relevant to clinical practice.
Aim 2. Evaluate if a transition from an inactive to active state translates into differences in concurrent and subsequent health-related quality adjusted life years (QALYs).
This aim i s relevant to health policy design and future planning of cost-effectiveness evaluations.
Aim 3. Determine the optimal physical activity threshold in the context of knee OA to maintain A) short term function and B) long term function;we will separately determine if each threshold differs by obesity subgroups.
This aim i s relevant to refining physical activity public health recommendations. Technical Aim. Create a prediction model crosswalk between uniaxial and triaxial physical activity measures from monitoring of n=200 OAI participants wearing both accelerometer technologies. This work will facilitate comparisons of public OAI data with future studies that use newer triaxial technology. Findings from this proposed study have important public health implications for the design of future physical activity intervention programs to improve quality of life among the 27 million U.S. adults who have OA.

Public Health Relevance

This study is built upon a strong scientific framework to evaluate the longitudinal relationship between changes in physical activity and health outcomes among adults with knee OA. The aims are designed to enlarge the public health and clinical practice paradigm to promote better health for persons at the low end of the physical activity spectrum. More attainable physical activity thresholds may provide realistic interim goals to promote increased physical activity, especially in people with arthritis who have pain and mobility problems.

National Institute of Health (NIH)
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Comprehensive Center (P60)
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Special Emphasis Panel (ZAR1-KM (M1))
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Northwestern University at Chicago
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Song, Jing; Chang, Alison H; Chang, Rowland W et al. (2017) Relationship of knee pain to time in moderate and light physical activities: Data from Osteoarthritis Initiative. Semin Arthritis Rheum :
Pellegrini, Christine A; Song, Jing; Semanik, Pamela A et al. (2017) Patients Less Likely to Lose Weight Following a Knee Replacement: Results From the Osteoarthritis Initiative. J Clin Rheumatol :
Gilbert, Abigail L; Lee, Jungwha; Ehrlich-Jones, Linda et al. (2017) A randomized trial of a motivational interviewing intervention to increase lifestyle physical activity and improve self-reported function in adults with arthritis. Semin Arthritis Rheum :
Pellegrini, Christine A; Ledford, Gwendolyn; Hoffman, Sara A et al. (2017) Preferences and motivation for weight loss among knee replacement patients: implications for a patient-centered weight loss intervention. BMC Musculoskelet Disord 18:327
White, Daniel K; Lee, Jungwha; Song, Jing et al. (2017) Potential Functional Benefit From Light Intensity Physical Activity in Knee Osteoarthritis. Am J Prev Med 53:689-696
Demirci, F Yesim; Wang, Xingbin; Morris, David L et al. (2017) Multiple signals at the extended 8p23 locus are associated with susceptibility to systemic lupus erythematosus. J Med Genet 54:381-389
Dunlop, Dorothy D; Song, Jing; Lee, Jungwha et al. (2017) Physical Activity Minimum Threshold Predicting Improved Function in Adults With Lower-Extremity Symptoms. Arthritis Care Res (Hoboken) 69:475-483
Sharma, L; Hochberg, M; Nevitt, M et al. (2017) Knee tissue lesions and prediction of incident knee osteoarthritis over 7 years in a cohort of persons at higher risk. Osteoarthritis Cartilage 25:1068-1075
Chang, A H; Chmiel, J S; Almagor, O et al. (2017) Association of baseline knee sagittal dynamic joint stiffness during gait and 2-year patellofemoral cartilage damage worsening in knee osteoarthritis. Osteoarthritis Cartilage 25:242-248
Sharma, Leena; Chang, Alison H; Jackson, Rebecca D et al. (2017) Varus Thrust and Incident and Progressive Knee Osteoarthritis. Arthritis Rheumatol 69:2136-2143

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