This study investigates an expanded paradigm to improve health outcomes for adults with knee osteoarthritis (OA), through changes in the low end of the physical activity spectrum where much of the knee OA population resides. Our recent study found almost half of adults with knee OA were inactive, as defined by the U.S. Department of Health and Human Services (DHHS) (i.e., no sustained 10 minute periods of moderate-to-vigorous intensity physical activity during a week) based on objective accelerometer measurement of physical activity. It is these inactive people who will be the primary focus of this study. This study will compare health outcomes of inactive adults at baseline who become active two years later versus inactive adults at baseline who remain inactive from the Osteoarthritis Initiative (OAI) cohort of adults with or at high risk of knee OA. This proposal will utilize valuable objective longitudinal physical activity data measured on a subsample from the OAI national cohort (n=2015) to accomplish the following:
Aim 1. Evaluate if a transition from inactivity to activity is related to short-term (at 2 years) function and longterm (at 4 years) function after controlling for baseline function, descriptive factors, modifiable health factors, and non-sedentary activity.
This aim i s relevant to clinical practice.
Aim 2. Evaluate if a transition from an inactive to active state translates into differences in concurrent and subsequent health-related quality adjusted life years (QALYs).
This aim i s relevant to health policy design and future planning of cost-effectiveness evaluations.
Aim 3. Determine the optimal physical activity threshold in the context of knee OA to maintain A) short term function and B) long term function;we will separately determine if each threshold differs by obesity subgroups.
This aim i s relevant to refining physical activity public health recommendations. Technical Aim. Create a prediction model crosswalk between uniaxial and triaxial physical activity measures from monitoring of n=200 OAI participants wearing both accelerometer technologies. This work will facilitate comparisons of public OAI data with future studies that use newer triaxial technology. Findings from this proposed study have important public health implications for the design of future physical activity intervention programs to improve quality of life among the 27 million U.S. adults who have OA.

Public Health Relevance

This study is built upon a strong scientific framework to evaluate the longitudinal relationship between changes in physical activity and health outcomes among adults with knee OA. The aims are designed to enlarge the public health and clinical practice paradigm to promote better health for persons at the low end of the physical activity spectrum. More attainable physical activity thresholds may provide realistic interim goals to promote increased physical activity, especially in people with arthritis who have pain and mobility problems.

Agency
National Institute of Health (NIH)
Institute
National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS)
Type
Comprehensive Center (P60)
Project #
1P60AR064464-01
Application #
8501983
Study Section
Special Emphasis Panel (ZAR1-KM (M1))
Project Start
Project End
Budget Start
2013-08-01
Budget End
2014-07-31
Support Year
1
Fiscal Year
2013
Total Cost
$292,195
Indirect Cost
$94,402
Name
Northwestern University at Chicago
Department
Type
DUNS #
005436803
City
Chicago
State
IL
Country
United States
Zip Code
60611
Parker, Ben; Urowitz, Murray B; Gladman, Dafna D et al. (2015) Impact of early disease factors on metabolic syndrome in systemic lupus erythematosus: data from an international inception cohort. Ann Rheum Dis 74:1530-6
Bruce, Ian N; O'Keeffe, Aidan G; Farewell, Vern et al. (2015) Factors associated with damage accrual in patients with systemic lupus erythematosus: results from the Systemic Lupus International Collaborating Clinics (SLICC) Inception Cohort. Ann Rheum Dis 74:1706-13
Chang, Rowland W; Semanik, Pamela A; Lee, Jungwha et al. (2014) Improving physical activity in arthritis clinical trial (IMPAACT): study design, rationale, recruitment, and baseline data. Contemp Clin Trials 39:224-35
Sun, Kai; Song, Jing; Manheim, Larry M et al. (2014) Relationship of meeting physical activity guidelines with quality-adjusted life-years. Semin Arthritis Rheum 44:264-70
Urowitz, Murray B; Gladman, Dafna D; Ibanez, Dominique et al. (2014) American College of Rheumatology Criteria at Inception, and Accrual over 5 Years in the SLICC Inception Cohort. J Rheumatol 41:875-80
Eckstein, F; Boudreau, R M; Wang, Z et al. (2014) Trajectory of cartilage loss within 4 years of knee replacement--a nested case-control study from the osteoarthritis initiative. Osteoarthritis Cartilage 22:1542-9
Hollon, Steven D; Arean, Patricia A; Craske, Michelle G et al. (2014) Development of clinical practice guidelines. Annu Rev Clin Psychol 10:213-41
Sohn, M-W; Manheim, L M; Chang, R W et al. (2014) Sedentary behavior and blood pressure control among osteoarthritis initiative participants. Osteoarthritis Cartilage 22:1234-40
Lertratanakul, Apinya; Wu, Peggy; Dyer, Alan et al. (2014) 25-hydroxyvitamin D and cardiovascular disease in patients with systemic lupus erythematosus: data from a large international inception cohort. Arthritis Care Res (Hoboken) 66:1167-76
Urowitz, M; Gladman, D D; Ibanez, D et al. (2014) Changes in quality of life in the first 5 years of disease in a multicentre cohort of patients with systemic lupus erythematosus (SLE). Arthritis Care Res (Hoboken) :

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