This application is to continue Albert Einstein College of Medicine's Diabetes Research and Training Center (DRTC) in order to support the discovery, application and translation of scientific knowledge for the treatment and cure of diabetes. The Einstein DRTC serves as a nexus to i) enhance diabetes research, education and training;ii) to attract, mentor and retain research investigators;iii) provide state-of-the-art Core services to maximize research productivity;iv) foster interdisciplinary collaborations, and v) to promote the translation of scientific findings from the bench to bedside and community, especially in underserved and minority populations. To accomplish these goals, we are requesting support for an administrative component with overall responsibility for management, integration and promotion of research and training. This component will supervise the Research Base, Biomedical and Prevention &Control Cores, the Enrichment and Pilot &Feasibility Study Programs. Since the previous application, the Einstein DRTC, through new leadership and Institutional commitment, has expanded the faculty Research Base, expanded and developed new Core functions and enhanced the Enrichment and Pilot &Feasibility Programs. In particular, over the past 16 months we have recruited 10 new Einstein DRTC faculty, appointed 4 existing senior Einstein faculty as members of the DRTC, based upon their new diabetes research focus, and provided full Einstein DRTC faculty membership to 8 faculty at other New York institutions as well as to the members of the Columbia DERC. Four new cutting-edge Biomedical Cores that complement and add to the services already provided by two existing Einstein DRTC cores and the other Institutional cores. The DRTC Biomedical Cores include, 1) Animal Physiology;2) Stable Isotope &Metabolomics;3) Hormone Assay;4) Analytical Imaging;5) Flow Cytometry;and 6) Epigenomics. The Prevention and Control (P&C) component has also expanded its research base of behavioral, health services, and epidemiological faculty and has established three functional units that include 1) Clinical Research Methodology;2) Behavioral Intervention/Evaluation Methodology and 3) Social-Environment Research Methodology. We have continued our outstanding Pilot &Feasibility Study Program through which new initiatives in basic, clinical, and behavioral research are supported. The Einstein DRTC Enrichment program has continued to host outstanding speakers, to videoconference and co-host seminars with Mount Sinai Medical School, to have weekly trainee Diabetes Workshop presentations and to provide Core educational workshops and training venues.

Public Health Relevance

Diabetes and related metabolic disorders are rapidly increasing and have major impacts on quality of life, lifespan responsible for a large portion of our health care cost burden. The goals of this project are to provide resources for molecular, cellular, tissue, organismal, pre-clinical, clinical and translation research to improve and deliver diabetes treatment.

Agency
National Institute of Health (NIH)
Institute
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Type
Comprehensive Center (P60)
Project #
5P60DK020541-35
Application #
8288824
Study Section
Special Emphasis Panel (ZDK1-GRB-2 (J2))
Program Officer
Hyde, James F
Project Start
1996-12-01
Project End
2015-03-31
Budget Start
2012-04-01
Budget End
2013-03-31
Support Year
35
Fiscal Year
2012
Total Cost
$1,859,711
Indirect Cost
$739,403
Name
Albert Einstein College of Medicine
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
110521739
City
Bronx
State
NY
Country
United States
Zip Code
10461
Lawman, Hannah G; Mallya, Giridhar; Veur, Stephanie Vander et al. (2015) Trends in relative weight over 1 year in low-income urban youth. Obesity (Silver Spring) 23:436-42
Conlon, Beth A; Kahan, Michelle; Martinez, Melissa et al. (2015) Development and Evaluation of the Curriculum for BOLD (Bronx Oncology Living Daily) Healthy Living: a Diabetes Prevention and Control Program for Underserved Cancer Survivors. J Cancer Educ 30:535-45
Lent, Michelle R; Vander Veur, Stephanie; Mallya, Giridhar et al. (2015) Corner store purchases made by adults, adolescents and children: items, nutritional characteristics and amount spent. Public Health Nutr 18:1706-12
Goyal, Akankasha; Nimmakayala, Kameswara Rao; Zonszein, Joel (2014) Is there a paradox in obesity? Cardiol Rev 22:163-70
Beasley, Jeannette M; Gunter, Marc J; LaCroix, Andrea Z et al. (2014) Associations of serum insulin-like growth factor-I and insulin-like growth factor-binding protein 3 levels with biomarker-calibrated protein, dairy product and milk intake in the Women's Health Initiative. Br J Nutr 111:847-53
Cuervo, Ana Maria; Wong, Esther (2014) Chaperone-mediated autophagy: roles in disease and aging. Cell Res 24:92-104
Abdulla, Arian; Zhang, Yi; Hsu, Fu-Ning et al. (2014) Regulation of lipogenic gene expression by lysine-specific histone demethylase-1 (LSD1). J Biol Chem 289:29937-47
Holmes, Michael V; Lange, Leslie A; Palmer, Tom et al. (2014) Causal effects of body mass index on cardiometabolic traits and events: a Mendelian randomization analysis. Am J Hum Genet 94:198-208
Bashiri, Asher; Heo, Hye J; Ben-Avraham, Danny et al. (2014) Pregnancy complicated by obesity induces global transcript expression alterations in visceral and subcutaneous fat. Mol Genet Genomics 289:695-705
Schneider, Jaime L; Suh, Yousin; Cuervo, Ana Maria (2014) Deficient chaperone-mediated autophagy in liver leads to metabolic dysregulation. Cell Metab 20:417-32

Showing the most recent 10 out of 404 publications