of the Einstein research base is provided below and is presented by area of emphasis. These areas represent the central base of the Einstein research efforts and are briefly highlighted here, but due to page limitations and the extensive diversity of our research faculty we are unable to fully describe all our research efforts. These descriptions include both the Einstein Diabetes Center faculty and the Center members from other institutions (indicated in bold). In any case, many of our investigators have research programs that cover several distinct areas but only one particular area with a few representative references are highlighted. The full list of current Diabetes Center members is provided on page 17 and the accompanying CD provides a complete list of publications by DRTC investigators that are directly related to the DRTC since the previous submission. This information covers the productivity of current Diabetes Center investigators since the submission of the last competitive renewal in 2006, plus a few pertinent previous projects/publications. Please note that this short time span reflects mainly the period of interim funding in contrast to the typical five-year cycle of Diabetes Center renewals. The primary research efforts of the Diabetes Center faculty can be divided into 6 overiapping and interactive areas of emphasis that encompass both Type 1 (T1DM) and Type 2 (T2DM) diabetes. These investigations cover the spectrum from basic molecular mechanisms, cell function, integrative system physiology, pre-clinical, clinical and community based health delivery management research. The major research directions are 1) Islet Biochemistry, Biology, and Immunology;2) Signal Transduction;3) Carbohydrate and Lipid Metabolism;4) Diabetic Complications and Molecular Genetics;5) Clinical Trials;and 6) Behavioral, Psychosocial and Environmental Detemiinants of Health and Health Disparities. In the following section, we summarize the faculty research base in each of these general research areas. Importantly in several of these areas, state-of-the-art animal model physiological studies are conducted providing paradigms for sophisticated human investigation, and vice-versa.

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National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
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Carey, Michelle; Gospin, Rebekah; Goyal, Akankasha et al. (2017) Opioid Receptor Activation Impairs Hypoglycemic Counterregulation in Humans. Diabetes 66:2764-2773
Bilanges, Benoit; Alliouachene, Samira; Pearce, Wayne et al. (2017) Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism. Nat Commun 8:1804
Jatkar, Aditi; Kurland, Irwin J; Judex, Stefan (2017) Diets High in Fat or Fructose Differentially Modulate Bone Health and Lipid Metabolism. Calcif Tissue Int 100:20-28
Viant, Mark R; Kurland, Irwin J; Jones, Martin R et al. (2017) How close are we to complete annotation of metabolomes? Curr Opin Chem Biol 36:64-69
Zahalka, Ali H; Arnal-Estapé, Anna; Maryanovich, Maria et al. (2017) Adrenergic nerves activate an angio-metabolic switch in prostate cancer. Science 358:321-326
Jao, Jennifer; Powis, Kathleen M; Kirmse, Brian et al. (2017) Lower mitochondrial DNA and altered mitochondrial fuel metabolism in HIV-exposed uninfected infants in Cameroon. AIDS 31:2475-2481
Bowden, John A; Heckert, Alan; Ulmer, Candice Z et al. (2017) Harmonizing lipidomics: NIST interlaboratory comparison exercise for lipidomics using SRM 1950-Metabolites in Frozen Human Plasma. J Lipid Res 58:2275-2288
Seki, Yoshinori; Suzuki, Masako; Guo, Xingyi et al. (2017) In Utero Exposure to a High-Fat Diet Programs Hepatic Hypermethylation and Gene Dysregulation and Development of Metabolic Syndrome in Male Mice. Endocrinology 158:2860-2872
Nie, Wenna; Yan, Leyu; Lee, Yie H et al. (2016) Advanced mass spectrometry-based multi-omics technologies for exploring the pathogenesis of hepatocellular carcinoma. Mass Spectrom Rev 35:331-49
Han, Wenfei; Tellez, Luis A; Niu, Jingjing et al. (2016) Striatal Dopamine Links Gastrointestinal Rerouting to Altered Sweet Appetite. Cell Metab 23:103-12

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