of the Einstein research base is provided below and is presented by area of emphasis. These areas represent the central base of the Einstein research efforts and are briefly highlighted here, but due to page limitations and the extensive diversity of our research faculty we are unable to fully describe all our research efforts. These descriptions include both the Einstein Diabetes Center faculty and the Center members from other institutions (indicated in bold). In any case, many of our investigators have research programs that cover several distinct areas but only one particular area with a few representative references are highlighted. The full list of current Diabetes Center members is provided on page 17 and the accompanying CD provides a complete list of publications by DRTC investigators that are directly related to the DRTC since the previous submission. This information covers the productivity of current Diabetes Center investigators since the submission of the last competitive renewal in 2006, plus a few pertinent previous projects/publications. Please note that this short time span reflects mainly the period of interim funding in contrast to the typical five-year cycle of Diabetes Center renewals. The primary research efforts of the Diabetes Center faculty can be divided into 6 overiapping and interactive areas of emphasis that encompass both Type 1 (T1DM) and Type 2 (T2DM) diabetes. These investigations cover the spectrum from basic molecular mechanisms, cell function, integrative system physiology, pre-clinical, clinical and community based health delivery management research. The major research directions are 1) Islet Biochemistry, Biology, and Immunology;2) Signal Transduction;3) Carbohydrate and Lipid Metabolism;4) Diabetic Complications and Molecular Genetics;5) Clinical Trials;and 6) Behavioral, Psychosocial and Environmental Detemiinants of Health and Health Disparities. In the following section, we summarize the faculty research base in each of these general research areas. Importantly in several of these areas, state-of-the-art animal model physiological studies are conducted providing paradigms for sophisticated human investigation, and vice-versa.

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Babad, Jeffrey; Ali, Riyasat; Schloss, Jennifer et al. (2016) An HLA-Transgenic Mouse Model of Type 1 Diabetes That Incorporates the Reduced but Not Abolished Thymic Insulin Expression Seen in Patients. J Diabetes Res 2016:7959060
Commissariat, Persis V; Kenowitz, Joslyn R; Trast, Jeniece et al. (2016) Developing a Personal and Social Identity With Type 1 Diabetes During Adolescence: A Hypothesis Generative Study. Qual Health Res 26:672-84
Mera, Paula; Laue, Kathrin; Ferron, Mathieu et al. (2016) Osteocalcin Signaling in Myofibers Is Necessary and Sufficient for Optimum Adaptation to Exercise. Cell Metab 23:1078-92
Ali, Riyasat; Babad, Jeffrey; Follenzi, Antonia et al. (2016) Genetically modified human CD4(+) T cells can be evaluated in vivo without lethal graft-versus-host disease. Immunology 148:339-51
Edison, Arthur S; Hall, Robert D; Junot, Christophe et al. (2016) The Time Is Right to Focus on Model Organism Metabolomes. Metabolites 6:
Chen, Wei; Melamed, Michal L; Hostetter, Thomas H et al. (2016) Effect of oral sodium bicarbonate on fibroblast growth factor-23 in patients with chronic kidney disease: a pilot study. BMC Nephrol 17:114
Gonzalez, Jeffrey S; Kane, Naomi S; Binko, Deborah H et al. (2016) Tangled Up in Blue: Unraveling the Links Between Emotional Distress and Treatment Adherence in Type 2 Diabetes. Diabetes Care 39:2182-2189
Roshandel, Delnaz; Klein, Ronald; Klein, Barbara E K et al. (2016) New Locus for Skin Intrinsic Fluorescence in Type 1 Diabetes Also Associated With Blood and Skin Glycated Proteins. Diabetes 65:2060-71
Nie, Wenna; Yan, Leyu; Lee, Yie H et al. (2016) Advanced mass spectrometry-based multi-omics technologies for exploring the pathogenesis of hepatocellular carcinoma. Mass Spectrom Rev 35:331-49
Yeh, M-C; Heo, M; Suchday, S et al. (2016) Translation of the Diabetes Prevention Program for diabetes risk reduction in Chinese immigrants in New York City. Diabet Med 33:547-51

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