The mission of the Analytical Imaging Core Is to assist DRTC investigators in routine and complex imaging technologies for their particular research needs. This is accomplished at several levels. First, the facility has traditionally emphasized teaching new users, on an individual basis, the imaging techniques they require for successful execution of their experiments. Appropriate staff effort is expended to address the needs of these laboratories by assisting them in experimental design, data collection, quantitative analysis and presentation. Secondly, the facility offers customized full service sample preparation for electron microscopy ranging from chemical fixation, embedding in resin and ultrathin sectioning, negative staining, immunogold labeling, critical point drying and metal shadowing. In addition, the facility offers a full range of low temperature techniques for electron microscopy including quick freezing in the millisecond range by plunge, metal mirror or high pressure freezing. Thirdly, the Analytical Imaging Core develops novel technologies and state-of-the-art methodologies to continually address the ongoing needs of the Einstein DRTC research laboratories. To accomplish these goals, the Analytical Imaging Core will: 1) advise investigators, trainees and staff on the best techniques and instrumentation to address their specific research problem;2) make available to investigators specialized light microscopy instrumentation for the analyses of cellular and molecular biological processes;3) provide dedicated electron microscopy expertise, service and training for the high resolution visualization of cellular, organelle, protein and nucleic acid structures;4) provide laboratory training of students, postdoctoral fellows, investigators and technical staff in performing techniques necessary to perform microscopy based analyses;5) assist in the appropriate data analysis for the evaluation of molecular targets and biological processes;and 6) continue the development of cutting-edge imaging methodologies and instrumentation. All these services are available to investigators new to diabetes research, as well as to investigators working on diabetes-related projects that can be enriched and extended by the use of the expertise and facilities of this core.
The Analytical Imaging Core provides cost effective, high quality resources that facilitate the scientific progress made by a large group of scientists committed to improve our understanding of the molecular and cellular basis of diabetes in order to improve the treatment of patients with diabetes.
|Lawman, Hannah G; Mallya, Giridhar; Veur, Stephanie Vander et al. (2015) Trends in relative weight over 1 year in low-income urban youth. Obesity (Silver Spring) 23:436-42|
|Conlon, Beth A; Kahan, Michelle; Martinez, Melissa et al. (2015) Development and Evaluation of the Curriculum for BOLD (Bronx Oncology Living Daily) Healthy Living: a Diabetes Prevention and Control Program for Underserved Cancer Survivors. J Cancer Educ 30:535-45|
|Lent, Michelle R; Vander Veur, Stephanie; Mallya, Giridhar et al. (2015) Corner store purchases made by adults, adolescents and children: items, nutritional characteristics and amount spent. Public Health Nutr 18:1706-12|
|Goyal, Akankasha; Nimmakayala, Kameswara Rao; Zonszein, Joel (2014) Is there a paradox in obesity? Cardiol Rev 22:163-70|
|Beasley, Jeannette M; Gunter, Marc J; LaCroix, Andrea Z et al. (2014) Associations of serum insulin-like growth factor-I and insulin-like growth factor-binding protein 3 levels with biomarker-calibrated protein, dairy product and milk intake in the Women's Health Initiative. Br J Nutr 111:847-53|
|Cuervo, Ana Maria; Wong, Esther (2014) Chaperone-mediated autophagy: roles in disease and aging. Cell Res 24:92-104|
|Abdulla, Arian; Zhang, Yi; Hsu, Fu-Ning et al. (2014) Regulation of lipogenic gene expression by lysine-specific histone demethylase-1 (LSD1). J Biol Chem 289:29937-47|
|Holmes, Michael V; Lange, Leslie A; Palmer, Tom et al. (2014) Causal effects of body mass index on cardiometabolic traits and events: a Mendelian randomization analysis. Am J Hum Genet 94:198-208|
|Bashiri, Asher; Heo, Hye J; Ben-Avraham, Danny et al. (2014) Pregnancy complicated by obesity induces global transcript expression alterations in visceral and subcutaneous fat. Mol Genet Genomics 289:695-705|
|Schneider, Jaime L; Suh, Yousin; Cuervo, Ana Maria (2014) Deficient chaperone-mediated autophagy in liver leads to metabolic dysregulation. Cell Metab 20:417-32|
Showing the most recent 10 out of 404 publications