This proposal will establish a new Diabetes Research and Training Center (DRTC) at the University of Alabama at Birmingham (UAB). The immediate goal of the center is to promote excellence in diabetes research. Through these efforts, the center ultimately endeavors to decrease morbidity/mortality and increase quality of life for our diabetes patients, and to provide an outstanding environment for student training and for faculty career development in diabetes research.
Our specific aims are to: 1. Facilitate and enhance diabetes research by establishing core technologies expressly required by our investigator base. These technologies will be effectively provided by three biomedical resource cores, Bioanalytical Redox Biology, Animal Physiology, and Human Biology Cores, and two Prevention &Control cores, the Metrics &Health Services Research and Community Engagement Cores. 2. Augment diabetes research via a pilot &feasibility grant program that will emphasize innovation, translation, and career development of highly promising junior investigators. 3. Promote a cohesive intellectual environment for an outstanding multi-disciplinary investigator base, which will enhance learning, collaboration, collegiality, and innovation. 4. Develop and evaluate new models of diabetes patient care that incorporate multi-disciplinary health care teams to improve patient outcomes, provide venues for clinical training, and create laboratories for translational and health services delivery research. 5. Leverage the resolve of UAB leadership, substantial institutional commitments, and generous philanthropy from our community to impel the development of a pre-eminent center of diabetes research excellence in the heart of the deep south. A new DRTC will have a high impact for diabetes research at UAB for several reasons including (i) our patients who have the highest rates of diabetes in the US, (ii) the collaborative and nurturing environment afforded research centers at UAB, and, most importantly, (iii) an outstanding investigator base with diabetes research excellence in human physiology, animal physiology, free radical biology and oxidative stress, inflammation, vascular biology, health disparities, health services, and community based research. Diabetes is both a metabolic and vascular disease, and one strategy employed by the DRTC is to unite metabolic and vascular researchers around these common themes to achieve a better understanding of the mechanisms, prevention, and control of diabetes, diabetes complications, and cardiometabolic risk.

National Institute of Health (NIH)
National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Comprehensive Center (P60)
Project #
Application #
Study Section
Special Emphasis Panel (ZDK1-GRB-S (O1))
Program Officer
Hyde, James F
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Alabama Birmingham
Schools of Allied Health Profes
United States
Zip Code
Hunter, Gary R; Moellering, Douglas R; Carter, Stephen J et al. (2017) Potential Causes of Elevated REE after High-Intensity Exercise. Med Sci Sports Exerc 49:2414-2421
Willig, Amanda L; Kramer, Philip A; Chacko, Balu K et al. (2017) Monocyte bioenergetic function is associated with body composition in virologically suppressed HIV-infected women. Redox Biol 12:648-656
Hunter, Gary R; Plaisance, Eric P; Carter, Stephen J et al. (2017) Why intensity is not a bad word: Optimizing health status at any age. Clin Nutr :
Ingram, K H; Hunter, G R; James, J F et al. (2017) Central fat accretion and insulin sensitivity: differential relationships in parous and nulliparous women. Int J Obes (Lond) 41:1214-1217
Snyder, Peter J; Kopperdahl, David L; Stephens-Shields, Alisa J et al. (2017) Effect of Testosterone Treatment on Volumetric Bone Density and Strength in Older Men With Low Testosterone: A Controlled Clinical Trial. JAMA Intern Med 177:471-479
Rowe, Glenn C; Asimaki, Angeliki; Graham, Evan L et al. (2017) Development of dilated cardiomyopathy and impaired calcium homeostasis with cardiac-specific deletion of ESRR?. Am J Physiol Heart Circ Physiol 312:H662-H671
Carter, Stephen J; Plaisance, Eric P; Fisher, Gordon et al. (2017) Alterations in Hemoglobin and Serum 25-hydroxyvitamin D are Related Before and After Weight Loss Independent of African Admixture. Int J Sport Nutr Exerc Metab 27:59-66
Budoff, Matthew J; Ellenberg, Susan S; Lewis, Cora E et al. (2017) Testosterone Treatment and Coronary Artery Plaque Volume in Older Men With Low Testosterone. JAMA 317:708-716
Prigge, Justin R; Coppo, Lucia; Martin, Sebastin S et al. (2017) Hepatocyte Hyperproliferation upon Liver-Specific Co-disruption of Thioredoxin-1, Thioredoxin Reductase-1, and Glutathione Reductase. Cell Rep 19:2771-2781
Resnick, Susan M; Matsumoto, Alvin M; Stephens-Shields, Alisa J et al. (2017) Testosterone Treatment and Cognitive Function in Older Men With Low Testosterone and Age-Associated Memory Impairment. JAMA 317:717-727

Showing the most recent 10 out of 235 publications