The SCOR-A program concerns the Early Natural History of Atherosclerosis and Essential Hypertension and includes both clinical and experimental research. The clinical research is studying 5,000 children in a well defined biracial population for cardiovascular risk factor variables, to determine the distribution and prevalence, interrelationship, and time-course changes of the risk factors. Serum lipids and lipoproteins, blood pressure, selected anthropometric measurements, and other variables - tobacco usage and fasting blood glucose and insulin - are under study. The epidemiologic design provides cross-sectional and longitudinal observations since changes over time are critical aspects of the program in an effort to predict future hypertension and hyperlipoproteinemia and the occurrence of multi-risk factors. """"""""Tracking"""""""" of the risk factor data is noted and indicates the merit of studying cardiovascular risk at an early age. Special sub-studies related to hypertension and hyperlipoproteinemia show racial differences which have implications for underlying biological mechanisms contributing to levels of risk factors. The experimental research includes nutrition studies on non-human primates to develop models of hypertension and hyperlipoproteinemia. A high sucrose intake has resulted in an exaggeration of the effect of oxogenous cholesterol on serum lipoproteins and on a salt induced hypertension. The chemistry of the arterial wall is also being studied to explore the role of proteoglycans in atherosclerosis and the biological properties of these macromolecules.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Comprehensive Center (P60)
Project #
5P60HL015103-15
Application #
3108414
Study Section
(SRC)
Project Start
1976-12-01
Project End
1987-11-30
Budget Start
1985-12-01
Budget End
1987-11-30
Support Year
15
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Louisiana State University Hsc New Orleans
Department
Type
Schools of Medicine
DUNS #
782627814
City
New Orleans
State
LA
Country
United States
Zip Code
70112