This application by the University of Alabama at Birmingham (UAB) proposes to expand our current NIMHD funded P60 Center of Excellence - "Comprehensive Minority and Health Disparities Research Center (MHDRC)" to generate new knowledge on minority health and health disparities in the areas of cancer prevention and control, cardiovascular disease, and their risk factors. This goal will be accomplished through a Research Core with two full research projects targeting Hispanic and African American populations. A Research Training Core will continue to build a pipeline of African American scientists through our partnership with Historically Black Colleges and Universities (HBCUs) in Alabama, and will expand this effort to include Hispanic students, a growing population in the state. A Community Engagement Core will enhance minority participation in research by building community capacity and engaging the community in the development and implementation of research studies. These goals will be met through the following specific aims:
Aim 1 : Conduct innovative interdisciplinary research to understand the complex interactions between biological, behavioral, and social factors associated with health disparities in cancer prevention and CVD/stroke. Specifically: a) Examine the impact of a theory-based, culturally relevant intervention in promoting HPV vaccine uptake among daughters of Latina immigrants between the ages of 9 and 12 through a group randomized controlled intervention;b) Develop a set of optimal stroke care Quality Improvement Measures (Qls) that maximizes outcomes for patients overall, and for specific groups of complex patients, such as Acute Ischemic Stroke (AIS) patients with Chronic Kidney Disease (CKD) or diabetes, both of which occur disproportionately among African Americans.
Aim 2 : Implement a Summer Enrichment Program to increase the number of competent and well-trained biomedical scientists who will work to eliminate health disparities in the Deep South. We will partner with Historically Black Colleges and Universities (HBCUs) in Alabama to implement a three-year, three-level program for undergraduate minority students to increase their likelihood of enrolling in health-related graduate programs and selecting careers in health research or practice.
Aim 3 : Enhance the participation of minority populations in clinical trials and research studies by building community capacity and engaging the community in the development and implementation of research.

Public Health Relevance

Phase III of the P60 Center of Excellence - Comprehensive Minority and Health Disparities Research Center (MHDRC) will generate new knowledge on minority health and health disparities in chronic disease, specifically in the areas of cancer prevention and control, cardiovascular disease, and their related risk factors in African American and Hispanic populations, with an emphasis on developing and testing interventions to reduce, and ultimately eliminate, these disparities.

National Institute of Health (NIH)
National Institute on Minority Health and Health Disparities (NIMHD)
Comprehensive Center (P60)
Project #
Application #
Study Section
Special Emphasis Panel (ZMD1-RN (02))
Program Officer
Castille, Dorothy M
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Alabama Birmingham
Internal Medicine/Medicine
Schools of Medicine
United States
Zip Code
Boehme, Amelia K; Siegler, James E; Mullen, Michael T et al. (2014) Racial and gender differences in stroke severity, outcomes, and treatment in patients with acute ischemic stroke. J Stroke Cerebrovasc Dis 23:e255-61
Boehme, Amelia K; Rawal, Pawan V; Lyerly, Michael J et al. (2014) Investigating the utility of previously developed prediction scores in acute ischemic stroke patients in the stroke belt. J Stroke Cerebrovasc Dis 23:2001-6
Petrov, Megan E; Sawyer, Patricia; Kennedy, Richard et al. (2014) Benzodiazepine (BZD) use in community-dwelling older adults: Longitudinal associations with mobility, functioning, and pain. Arch Gerontol Geriatr 59:331-7
Petrov, Megan E; Howard, Virginia J; Kleindorfer, Dawn et al. (2014) Over-the-counter and prescription sleep medication and incident stroke: the REasons for Geographic and Racial Differences in Stroke study. J Stroke Cerebrovasc Dis 23:2110-6
Chang, Tiffany R; Albright, Karen C; Boehme, Amelia K et al. (2014) Factor VIII in the setting of acute ischemic stroke among patients with suspected hypercoagulable state. Clin Appl Thromb Hemost 20:124-8
Mullen, Michael T; Wiebe, Douglas J; Bowman, Ariel et al. (2014) Disparities in accessibility of certified primary stroke centers. Stroke 45:3381-8
Lyerly, Michael J; Houston, J Thomas; Boehme, Amelia K et al. (2014) Safety of intravenous tissue plasminogen activator administration with computed tomography evidence of prior infarction. J Stroke Cerebrovasc Dis 23:1657-61
Boehme, Amelia K; Kapoor, Niren; Albright, Karen C et al. (2014) Predictors of systemic inflammatory response syndrome in ischemic stroke undergoing systemic thrombolysis with intravenous tissue plasminogen activator. J Stroke Cerebrovasc Dis 23:e271-6
Mathias, Tiffany L; Albright, Karen C; Boehme, Amelia K et al. (2014) The Impact of Myocardial Infarction vs. Pneumonia on Outcome in Acute Ischemic Stroke. J Cardiovasc Dis 2:1-3
Petrov, Megan E; Kim, Yongin; Lauderdale, Diane S et al. (2014) Objective sleep, a novel risk factor for alterations in kidney function: the CARDIA study. Sleep Med 15:1140-6

Showing the most recent 10 out of 28 publications