The Research Core will generate new knowledge on minority health and chronic disease, specifically cancer and cardiovascular disease, with emphasis on developing and testing interventions to reduce these disparities. The Core will combine oversight of two P60-supported full research projects with an innovative pilot project program that leverages NIH funding with institutional and philanthropic funding. The Research Core will capitalize on the successful research conducted in the previous two phases of our P60 Center of Excellence, and will make use of the infrastructure of the UAB-supported Minority Health &Health Disparities Research Center (MHRC). Thus it will advance our understanding of health disparities and enhance our efforts to eliminate them.
Specific aims are:
Aim 1 : Oversee the implementation of two full research projects: 1."Promoting HPV Vaccine Uptake among Daughters of Latina Immigrants";and 2. "Improving Stroke Outcomes for African Americans." Aim 2: Facilitate the development and submission of new research projects on health disparities for extramural funding through: a) Promotion of research consistent with our overall focus (chronic disease, specifically cancer prevention and CVD risk factors and stroke), themes (minority health and health disparities), and emphasis (understanding and intervening);b) Review of and scientific contributions to proposals;c) Statistical and research infrastructure support for proposals (e.g., sample-size computations, analytic plans, and data management procedures).
Aim 3 : Identify additional resources through the institutionally supported Minority Health &Health Disparities Research Center (MHRC) and in collaboration with other UAB centers and schools to provide funds to junior faculty to conduct pilot projects related to health disparities. We will leverage MHDRC funds with those of the MHRC for a steady state of 2-3 pilot projects annually.
Aim 4 : Integrate multiple sources of expertise on minority health and health disparities with the research base of the MHDRC for intellectual cross-fertilization and leveraging of resources. Specifically: a) conduct seminars;b) an annual Health Disparities Research Symposium to promote research on health disparities, share knowledge, and cultivate interactions and networking among scientists;and c) direct scientists to other appropriate UAB research resources.

National Institute of Health (NIH)
Comprehensive Center (P60)
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Special Emphasis Panel (ZMD1)
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University of Alabama Birmingham
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Boehme, Amelia K; Siegler, James E; Mullen, Michael T et al. (2014) Racial and gender differences in stroke severity, outcomes, and treatment in patients with acute ischemic stroke. J Stroke Cerebrovasc Dis 23:e255-61
Boehme, Amelia K; Rawal, Pawan V; Lyerly, Michael J et al. (2014) Investigating the utility of previously developed prediction scores in acute ischemic stroke patients in the stroke belt. J Stroke Cerebrovasc Dis 23:2001-6
Petrov, Megan E; Sawyer, Patricia; Kennedy, Richard et al. (2014) Benzodiazepine (BZD) use in community-dwelling older adults: Longitudinal associations with mobility, functioning, and pain. Arch Gerontol Geriatr 59:331-7
Petrov, Megan E; Howard, Virginia J; Kleindorfer, Dawn et al. (2014) Over-the-counter and prescription sleep medication and incident stroke: the REasons for Geographic and Racial Differences in Stroke study. J Stroke Cerebrovasc Dis 23:2110-6
Chang, Tiffany R; Albright, Karen C; Boehme, Amelia K et al. (2014) Factor VIII in the setting of acute ischemic stroke among patients with suspected hypercoagulable state. Clin Appl Thromb Hemost 20:124-8
Mullen, Michael T; Wiebe, Douglas J; Bowman, Ariel et al. (2014) Disparities in accessibility of certified primary stroke centers. Stroke 45:3381-8
Lyerly, Michael J; Houston, J Thomas; Boehme, Amelia K et al. (2014) Safety of intravenous tissue plasminogen activator administration with computed tomography evidence of prior infarction. J Stroke Cerebrovasc Dis 23:1657-61
Boehme, Amelia K; Kapoor, Niren; Albright, Karen C et al. (2014) Predictors of systemic inflammatory response syndrome in ischemic stroke undergoing systemic thrombolysis with intravenous tissue plasminogen activator. J Stroke Cerebrovasc Dis 23:e271-6
Mathias, Tiffany L; Albright, Karen C; Boehme, Amelia K et al. (2014) The Impact of Myocardial Infarction vs. Pneumonia on Outcome in Acute Ischemic Stroke. J Cardiovasc Dis 2:1-3
Petrov, Megan E; Kim, Yongin; Lauderdale, Diane S et al. (2014) Objective sleep, a novel risk factor for alterations in kidney function: the CARDIA study. Sleep Med 15:1140-6

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