Lymphedema (LE) remains a major health problem affecting thousands of breast cancer survivors. Significantly lower quality of life is observed in survivors with LE than those without. LE following breast cancer treatment is characterized by an accumulation of lymph fluid in the interstitial spaces of the affected limb and areas, leading to a syndrome of abnormal swelling and multiple distressing symptoms. Survivors with fluid accumulation are at greater risk for repeated cellulitis, infections, and lymphangitis, which creates financial and economic burdens not only to survivors but also to the healthcare system. Preoperative assessment, educational and behavioral interventions are showing effectiveness to maintain limb volume, ameliorate LE symptoms and promote early detection. This project proposes to improve clinical practice by implementing and preliminarily evaluating an educational and behavioral intervention (The Optimal YOU) to enhance LE risk reduction among Chinese-speaking breast cancer survivors. The Optimal YOU intervention focuses on promoting lymph flow, preventing inflammation-infection, and maintaining optimal body mass index. Evaluation of the feasibility, acceptability, and effectiveness of the intervention has been demonstrated in English-speaking breast cancer survivors. Yet in its current form, this very promising program is not available to non-English-speaking women.
The aims of the project are to: (1) translate and adapt The Optimal YOU intervention from English language into Chinese language;(2) Preliminarily evaluate the feasibility and acceptability of implementation of the intervention through focus group approach;and (3) preliminarily examine the intervention on the process of participation, attrition, satisfaction, cost, and intervention fidelity as well as the effectiveness by conducting a randomized controlled clinical trial and comparing the intervention outcomes at preoperative baseline, 4-8 weeks, 6 months, and 12 months follow-up. Special attention will be on the identification of cultural and linguistic factors that promote or impede the implementation of the intervention.

Public Health Relevance

Lymphedema (LE), a major adverse effect from breast cancer treatment, can cause long-term physical, psychological, social, and financial problems. This project proposes to minimize health disparities in LE risk reduction by implementing and preliminarily evaluating an educational and behavioral intervention to enhance LE risk reduction among Chinese-speaking breast cancer survivors.

National Institute of Health (NIH)
National Institute on Minority Health and Health Disparities (NIMHD)
Comprehensive Center (P60)
Project #
Application #
Study Section
Special Emphasis Panel (ZMD1-RN (02))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
New York University
New York
United States
Zip Code
Riley, Lindsey; Mili, Saima; Trinh-Shevrin, Chau et al. (2016) Using Qualitative Methods to Understand Physical Activity and Weight Management Among Bangladeshis in New York City, 2013. Prev Chronic Dis 13:E87
Al-Bayan, Maliyhah; Islam, Nadia; Edwards, Shawneaqua et al. (2016) Neighborhood perceptions and hypertension among low-income black women: a qualitative study. BMC Public Health 16:1075
Fu, Mei R; Conley, Yvette P; Axelrod, Deborah et al. (2016) Precision assessment of heterogeneity of lymphedema phenotype, genotypes and risk prediction. Breast 29:231-40
Yi, Stella S; Trinh-Shevrin, Chau; Yen, Irene H et al. (2016) Racial/Ethnic Differences in Associations Between Neighborhood Social Cohesion and Meeting Physical Activity Guidelines, United States, 2013-2014. Prev Chronic Dis 13:E165
Islam, Nadia S; Patel, Shilpa; Wyatt, Laura C et al. (2016) Sources of Health Information Among Select Asian American Immigrant Groups in New York City. Health Commun 31:207-16
Fu, Mei R; Axelrod, Deborah; Guth, Amber A et al. (2016) mHealth self-care interventions: managing symptoms following breast cancer treatment. Mhealth 2:
Nadimpalli, Sarah B; Cleland, Charles M; Hutchinson, M Katherine et al. (2016) The association between discrimination and the health of Sikh Asian Indians. Health Psychol 35:351-5
Fu, Mei Rosemary; Axelrod, Deborah; Guth, Amber et al. (2016) A Web- and Mobile-Based Intervention for Women Treated for Breast Cancer to Manage Chronic Pain and Symptoms Related to Lymphedema: Randomized Clinical Trial Rationale and Protocol. JMIR Res Protoc 5:e7
Huang, Keng-Yen; Calzada, Esther; Cheng, Sabrina et al. (2016) Cultural Adaptation, Parenting and Child Mental Health Among English Speaking Asian American Immigrant Families. Child Psychiatry Hum Dev :
Yi, Stella S; Johns, Michael; Lim, Sungwoo (2016) Use of Regional Data to Validate and Recalibrate Self-reported Hypertension: Highlighting Differences in Immigrant Groups in New York City. J Immigr Minor Health 18:202-9

Showing the most recent 10 out of 101 publications