Physical morbidity and mortality disparities consistently favor non-Hispanic whites over black Americans. Epidemiological studies reveal that black Americans suffer the same or lower rates of mental disorders as whites. In highly stressful environments individuals often engage in negative health behaviors, e.g. smoking, alcohol use and abuse, drug use, and over-eating, to cope with the stressors of daily life. These behaviors, perhaps through mechanisms associated with the HPA axis, alleviate the stressful reactions to these environmental exposures; the same chronic stress exposures and poor health behaviors that are silently affecting biological pathways to eventual negative physical health morbidity and mortality. Thus, lower rates of mental disorders among the African American population are at the expense of higher physical health morbidities and mortality in comparison to the non-Hispanic white population. We hypothesize and present a complex framework involving environmental factors, chronic stressors, and the stress response through the HPA-Axis, that account for the interrelationship among mental disorders and cardiovascular health outcomes. The observed epidemiological and clinical physical health/mental disorder paradox will be addressed using: 1) analyses of existing large epidemiological datasets; 2) analyses of survey and clinical datasets containing epidemiological, risk factor, and biological indicators; and, 3) a longitudinal cohort, clinical study examining in detail the relationship among biological and social risk factors, biomarkers for cardiovascular health and mood disorders, among black and white women. There are three interrelated, multi-disciplinary, specific aims, at increasing levels of specificity: 1) analyses of observational/epidemiological data on physical and mental disorders, 2) analyses of potential biological pathways of physical morbidity and mental disorder interrelationships in observational/epidemiological studies, and 3) a clinic based 112 month longitudinal study of potential interventions that affect cardiovascular risk behaviors and risk and resilience biomarkers, and risks for mood disorders and biomarkers for stress and HPA functioning, among African American as compared to non-Hispanic white women.

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Comprehensive Center (P60)
Project #
5P60MD002249-05
Application #
8353392
Study Section
Special Emphasis Panel (ZMD1-LW (07))
Project Start
Project End
Budget Start
2011-09-01
Budget End
2012-08-31
Support Year
5
Fiscal Year
2011
Total Cost
$380,000
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Ward, Julia B; Feinstein, Lydia; Vines, Anissa I et al. (2017) Perceived discrimination and depressive symptoms among US Latinos: the modifying role of educational attainment. Ethn Health :1-16
Christine, Paul J; Moore, Kari; Crawford, Natalie D et al. (2017) Exposure to Neighborhood Foreclosures and Changes in Cardiometabolic Health: Results From MESA. Am J Epidemiol 185:106-114
Smith, Jennifer A; Zhao, Wei; Yasutake, Kalyn et al. (2017) Gene-by-Psychosocial Factor Interactions Influence Diastolic Blood Pressure in European and African Ancestry Populations: Meta-Analysis of Four Cohort Studies. Int J Environ Res Public Health 14:
Riestra, Pia; Gebreab, Samson Y; Xu, Ruihua et al. (2017) Circadian CLOCK gene polymorphisms in relation to sleep patterns and obesity in African Americans: findings from the Jackson heart study. BMC Genet 18:58
Hastert, T A; de Oliveira Otto, M C; LĂȘ-Scherban, F et al. (2017) Association of plasma phospholipid polyunsaturated and trans fatty acids with body mass index: Results from the multi-ethnic study of atherosclerosis. Int J Obes (Lond) :
Baek, Jonggyu; Hirsch, Jana A; Moore, Kari et al. (2017) Statistical Methods to Study Variation in Associations Between Food Store Availability and Body Mass in the Multi-Ethnic Study of Atherosclerosis. Epidemiology 28:403-411
Mezuk, Briana; Ratliff, Scott; Concha, Jeannie B et al. (2017) Stress, self-regulation, and context: Evidence from the Health and Retirement Survey. SSM Popul Health 3:455-463
Hussein, Mustafa; Diez Roux, Ana V; Mujahid, Mahasin S et al. (2017) Unequal Exposure or Unequal Vulnerability? Contributions of Neighborhood Conditions and Cardiovascular Risk Factors to Socioeconomic Inequality in Incident Cardiovascular Disease in the Multi-Ethnic Study of Atherosclerosis. Am J Epidemiol :
Johnson, Dayna A; Simonelli, Guido; Moore, Kari et al. (2017) The Neighborhood Social Environment and Objective Measures of Sleep in the Multi-Ethnic Study of Atherosclerosis. Sleep 40:
Brenner, Allison B; Diez-Roux, Ana V; Gebreab, Samson Y et al. (2017) The Epidemiology of Coping in African American Adults in the Jackson Heart Study (JHS). J Racial Ethn Health Disparities :

Showing the most recent 10 out of 171 publications