Multiple studies have compared cardiovascular risk factors and cardiovascular outcomes in African American and white populations. These comparisons implicitly assume relative homogeneity in risk within race/ethnic groups yet cardiovascular risk is markedly heterogeneous within African Americans. Social and psychosocial factors alone or in interaction with genetic predispositions may be important contributors to this heterogeneity. Understanding the causes of this heterogeneity is important for reducing the burden of cardiovascular disease in African Americans and for reducing health disparities. The overall scientific goals of the Project are (1) to investigate socioeconomic and psychosocial predictors of longitudinal changes in cardiovascular risk factors and incident cardiovascular events in African Americans, and the factors that may contribute to the effects of these factors;(2) to explore whether social or psychosocial factors modify the impact of previously identified genetic predictors of blood pressure, body mass index, and diabetes. This project builds on the findings of the prior funding period and the very successful partnership between the University of Michigan and the Jackson Heart Study. In addition to the scientific aims, a major goal of the project is to enhance the scientific productivity of JHS generally, with a special emphasis on enhancing the edacity and productivity of JHS investigators at Jackson State and at the University of Mississippi. Our approach is novel in that we will examine heterogeneity within African Americans using a state of the art cohort study with uniquely rich measurement in both the sociocultural and biologic domains. This will allow us to investigate not only social and psychosocial predictors of longitudinal changes in CVD risks factors and events but also their interaction with genetic predispositions. We will replicate key gene-environment analyses in other large cohorts with similar measurements. Our research project is integrated with training/mentoring activities designed specifically for young researchers interested in health disparities and is also closely linked to the Community Engagement/Outreach Core which will disseminate our findings and assist in translating them into policy. Our proposal is innovative in its integrated social/biological approach and in its strong links to training and community activities directly connected to the scientific goals of the project.

Public Health Relevance

This project will investigate how social and biologic factors interact to shape the distribution of cardiovascular risk among African Americans. The identification of factors related to heterogeneity in cardiovascular risk within African Americans is important to identify the pretevention strategies most likely to be effective.

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Comprehensive Center (P60)
Project #
2P60MD002249-06
Application #
8351389
Study Section
Special Emphasis Panel (ZMD1-RN (02))
Project Start
2007-09-01
Project End
2017-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
6
Fiscal Year
2012
Total Cost
$184,652
Indirect Cost
$58,300
Name
University of Michigan Ann Arbor
Department
Type
DUNS #
073133571
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
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Concha, Jeannie Belinda; Mayer, Sallie D; Mezuk, Briana R et al. (2016) Diabetes Causation Beliefs Among Spanish-Speaking Patients. Diabetes Educ 42:116-25
Ford, Cassandra D; Sims, Mario; Higginbotham, John C et al. (2016) Psychosocial Factors Are Associated With Blood Pressure Progression Among African Americans in the Jackson Heart Study. Am J Hypertens 29:913-24
Booth 3rd, John N; Diaz, Keith M; Seals, Samantha R et al. (2016) Masked Hypertension and Cardiovascular Disease Events in a Prospective Cohort of Blacks: The Jackson Heart Study. Hypertension 68:501-10
Baek, Jonggyu; Sánchez, Brisa N; Berrocal, Veronica J et al. (2016) Distributed Lag Models: Examining Associations Between the Built Environment and Health. Epidemiology 27:116-24
Lacey, Krim K; Mouzon, Dawne M; Govia, Ishtar O et al. (2016) Substance Abuse Among Blacks Across the Diaspora. Subst Use Misuse 51:1147-58
Diez Roux, Ana V; Mujahid, Mahasin S; Hirsch, Jana A et al. (2016) The Impact of Neighborhoods on CV Risk. Glob Heart 11:353-363
Barber, Sharrelle; Hickson, DeMarc A; Kawachi, Ichiro et al. (2016) Double-jeopardy: The joint impact of neighborhood disadvantage and low social cohesion on cumulative risk of disease among African American men and women in the Jackson Heart Study. Soc Sci Med 153:107-15
Hudson, Darrell L; Neighbors, Harold W; Geronimus, Arline T et al. (2016) Racial Discrimination, John Henryism, and Depression Among African Americans. J Black Psychol 42:221-243
Johnson, Dayna A; Lisabeth, Lynda; Hickson, DeMarc et al. (2016) The Social Patterning of Sleep in African Americans: Associations of Socioeconomic Position and Neighborhood Characteristics with Sleep in the Jackson Heart Study. Sleep 39:1749-59

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