The proposed research project explores racial and ethnic group disparities in physical and mental health by continuing to develop the Environmental Affordances Framework (EAF). Relative to non-Hispanic whites, black Americans have a higher burden of physical health conditions and mortality, but similar or lower risks for most mental disorders, in highly stressful environments individuals often engage in environmentally available negative health behaviors, e.g. smoking, alcohol use, and over-eating to cope with the stressors of daily life. These negative health behaviors may either block the neurological cascade or mask the psychological experiences of poor mental health, by acting on the hypothalamic-pituitary-adrenalcortical (HPA) axis and related neurobiological systems, thus exerting a protective effect on mental health. However, the same chronic stress exposures and poor health behaviors are silently affecting biological pathways to eventual negative physical health morbidities and mortality. Collectively the aims of the proposed study represent a direct extension of the EAF. First, using propensity score analysis we will explore the contrasting findings across racial groups, in an attempt to unmask what we have entitled the """"""""masquerade of racial group differences"""""""". Second, we will examine the differential age of onset of physical and mental disorders among racial groups. Third, we will assess pathways linking social and environmental factors, psychosocial stress, biological markers of stress, and cardiovascular health;we will examine statistical models separately among males and females, and then assess by age cohort. In a sub objective of this Aim we will explore potential gene expression - environment interactions in understanding the differential prevalence of hypertension and other cardiovascular outcomes. Key environmental and social factors include skin tone and experiences with discrimination. Fourth, we will conduct a small clinical pilot study to assess the potential protective effects of mindfulness meditation and other interventions to reduce racial group disparities in cardiovascular health and mental health. Mindfulness meditation may have similar effects on the HPA-axis stress response as do poor health behaviors.

Public Health Relevance

Cardiovascular disease (CVD) continues to top public health agendas. Across all forms'of CVD rates of long-term adherence to recommended healthy behavioral changes are spotty at best. We believe that physical and mental health disparities are linked to the lack of behavioral change adherence. The findings of this study will aid in developing programs and policies needed to address the physical and mental health challenges in racial and ethnic disparities related to cardiovascular and other metabolic disorders.

National Institute of Health (NIH)
National Institute on Minority Health and Health Disparities (NIMHD)
Comprehensive Center (P60)
Project #
Application #
Study Section
Special Emphasis Panel (ZMD1-RN (02))
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
University of Michigan Ann Arbor
Ann Arbor
United States
Zip Code
Ward, Julia B; Feinstein, Lydia; Vines, Anissa I et al. (2017) Perceived discrimination and depressive symptoms among US Latinos: the modifying role of educational attainment. Ethn Health :1-16
Christine, Paul J; Moore, Kari; Crawford, Natalie D et al. (2017) Exposure to Neighborhood Foreclosures and Changes in Cardiometabolic Health: Results From MESA. Am J Epidemiol 185:106-114
Smith, Jennifer A; Zhao, Wei; Yasutake, Kalyn et al. (2017) Gene-by-Psychosocial Factor Interactions Influence Diastolic Blood Pressure in European and African Ancestry Populations: Meta-Analysis of Four Cohort Studies. Int J Environ Res Public Health 14:
Riestra, Pia; Gebreab, Samson Y; Xu, Ruihua et al. (2017) Circadian CLOCK gene polymorphisms in relation to sleep patterns and obesity in African Americans: findings from the Jackson heart study. BMC Genet 18:58
Hastert, T A; de Oliveira Otto, M C; LĂȘ-Scherban, F et al. (2017) Association of plasma phospholipid polyunsaturated and trans fatty acids with body mass index: Results from the multi-ethnic study of atherosclerosis. Int J Obes (Lond) :
Baek, Jonggyu; Hirsch, Jana A; Moore, Kari et al. (2017) Statistical Methods to Study Variation in Associations Between Food Store Availability and Body Mass in the Multi-Ethnic Study of Atherosclerosis. Epidemiology 28:403-411
Mezuk, Briana; Ratliff, Scott; Concha, Jeannie B et al. (2017) Stress, self-regulation, and context: Evidence from the Health and Retirement Survey. SSM Popul Health 3:455-463
Hussein, Mustafa; Diez Roux, Ana V; Mujahid, Mahasin S et al. (2017) Unequal Exposure or Unequal Vulnerability? Contributions of Neighborhood Conditions and Cardiovascular Risk Factors to Socioeconomic Inequality in Incident Cardiovascular Disease in the Multi-Ethnic Study of Atherosclerosis. Am J Epidemiol :
Johnson, Dayna A; Simonelli, Guido; Moore, Kari et al. (2017) The Neighborhood Social Environment and Objective Measures of Sleep in the Multi-Ethnic Study of Atherosclerosis. Sleep 40:
Brenner, Allison B; Diez-Roux, Ana V; Gebreab, Samson Y et al. (2017) The Epidemiology of Coping in African American Adults in the Jackson Heart Study (JHS). J Racial Ethn Health Disparities :

Showing the most recent 10 out of 171 publications