Purpose, Structure and Function The overall purpose of the Research Core is to provide a structure that supports the work of the research projects, each of which requires recruitment of human subjects and acquisition of biological samples. Working with Core Investigators, the research Core staff identify potential research subjects, explain the study, assess inclusion and exclusion issues, obtain informed consent, and obtain samples when applicable. The Research Core staff collects and stores samples of DNA from mothers and fathers using buccal swabs, and samples of DNA from babies using sections of umbilical cords. The Core research staff will collect, process and store blood samples and samples of placentas, fetal membranes, decidua and umbilical cords. The Research Core will offer cost-effective approaches to subject recruitment for all three research projects, as well as assistance in methods that will be common to all in terms of tissue acquisition and processing, nucleic acid extraction and quantitation, and histological evaluation of tissues. The Research Core will also facilitate distribution of samples to other University research core services described below. The recruitment needs for each research project are detailed in the individual project descriptions. These recruitment and sample processing needs were developed in consultation with the Research Core Director. The resources of the Research Core were scaled to meet the collective needs of the projects. African Americans comprise 66% of the patients in the Labor and Delivery Unit of MCV Hospitals. In addition, collaborative arrangements have been made with other institutions. Maternal-fetal dyad samples were collected for DNA analysis for Project 1 in collaborative arrangements with the University of Pennsylvania. Hutzel Women's Hospital of Wayne State University and Sotero del Rio Hospital in Santiago, Chile as part of a database of samples from the Perinatology Research Branch, NICHD. The Research Core houses samples until they can be delivered to the investigators. Samples are labeled with the subject number as the only identifier. Investigators using samples will have completed the CITI human subjects research training, have a protocol approved by the VCU-IRB. and have a signed consent form indicating that subjects have agreed to provide samples for the study.

Agency
National Institute of Health (NIH)
Institute
National Institute on Minority Health and Health Disparities (NIMHD)
Type
Comprehensive Center (P60)
Project #
5P60MD002256-07
Application #
8470240
Study Section
Special Emphasis Panel (ZMD1-RN)
Project Start
Project End
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
7
Fiscal Year
2013
Total Cost
$81,102
Indirect Cost
$26,853
Name
Virginia Commonwealth University
Department
Type
DUNS #
105300446
City
Richmond
State
VA
Country
United States
Zip Code
23298
Brooks, J Paul; Edwards, David J; Blithe, Diana L et al. (2016) Effects of combined oral contraceptives, depot medroxyprogesterone acetate and the levonorgestrel-releasing intrauterine system on the vaginal microbiome. Contraception :
Seinfeld, Syndi A; Pellock, John M; Kjeldsen, Marianne J et al. (2016) Epilepsy After Febrile Seizures: Twins Suggest Genetic Influence. Pediatr Neurol 55:14-6
Kinser, Patricia A; Robins, Jo Lynne W; Masho, Saba W (2016) Self-Administered Mind-Body Practices for Reducing Health Disparities: An Interprofessional Opinion and Call to Action. Evid Based Complement Alternat Med 2016:2156969
Wright, Michelle L; Dozmorov, Mikhail G; Wolen, Aaron R et al. (2016) Establishing an analytic pipeline for genome-wide DNA methylation. Clin Epigenetics 8:45
Do, Elizabeth K; Latendresse, Shawn J; Edwards, Alexis C et al. (2016) Associations Between Gestational Age at Birth and Alcohol Use in the Avon Longitudinal Study of Parents and Children. Alcohol Clin Exp Res 40:1328-38
Wright, Michelle L; Starkweather, Angela R; York, Timothy P (2016) Mechanisms of the Maternal Exposome and Implications for Health Outcomes. ANS Adv Nurs Sci 39:E17-30
Abdelmaksoud, Abdallah A; Koparde, Vishal N; Sheth, Nihar U et al. (2016) Comparison of Lactobacillus crispatus isolates from Lactobacillus-dominated vaginal microbiomes with isolates from microbiomes containing bacterial vaginosis-associated bacteria. Microbiology 162:466-75
Lind, Mackenzie J; Aggen, Steven H; Kendler, Kenneth S et al. (2016) An epidemiologic study of childhood sexual abuse and adult sleep disturbances. Psychol Trauma 8:198-205
Berenz, Erin C; Kevorkian, Salpi; Chowdhury, Nadia et al. (2016) Posttraumatic stress disorder symptoms, anxiety sensitivity, and alcohol-use motives in college students with a history of interpersonal trauma. Psychol Addict Behav 30:755-763
Vanderbilt, Allison A; Wright, Marcie S; Brewer, Alisa E et al. (2016) Increasing Knowledge and Health Literacy about Preterm Births in Underserved Communities: An Approach to Decrease Health Disparities, a Pilot Study. Glob J Health Sci 8:83-9

Showing the most recent 10 out of 70 publications