Purpose, Structure and Function The overall purpose of the Research Core is to provide a structure that supports the work of the research projects, each of which requires recruitment of human subjects and acquisition of biological samples. Working with Core Investigators, the research Core staff identify potential research subjects, explain the study, assess inclusion and exclusion issues, obtain informed consent, and obtain samples when applicable. The Research Core staff collects and stores samples of DNA from mothers and fathers using buccal swabs, and samples of DNA from babies using sections of umbilical cords. The Core research staff will collect, process and store blood samples and samples of placentas, fetal membranes, decidua and umbilical cords. The Research Core will offer cost-effective approaches to subject recruitment for all three research projects, as well as assistance in methods that will be common to all in terms of tissue acquisition and processing, nucleic acid extraction and quantitation, and histological evaluation of tissues. The Research Core will also facilitate distribution of samples to other University research core services described below. The recruitment needs for each research project are detailed in the individual project descriptions. These recruitment and sample processing needs were developed in consultation with the Research Core Director. The resources of the Research Core were scaled to meet the collective needs of the projects. African Americans comprise 66% of the patients in the Labor and Delivery Unit of MCV Hospitals. In addition, collaborative arrangements have been made with other institutions. Maternal-fetal dyad samples were collected for DNA analysis for Project 1 in collaborative arrangements with the University of Pennsylvania. Hutzel Women's Hospital of Wayne State University and Sotero del Rio Hospital in Santiago, Chile as part of a database of samples from the Perinatology Research Branch, NICHD. The Research Core houses samples until they can be delivered to the investigators. Samples are labeled with the subject number as the only identifier. Investigators using samples will have completed the CITI human subjects research training, have a protocol approved by the VCU-IRB. and have a signed consent form indicating that subjects have agreed to provide samples for the study.

National Institute of Health (NIH)
National Institute on Minority Health and Health Disparities (NIMHD)
Comprehensive Center (P60)
Project #
Application #
Study Section
Special Emphasis Panel (ZMD1-RN)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Virginia Commonwealth University
United States
Zip Code
Fettweis, Jennifer M; Serrano, Myrna G; Huang, Bernice et al. (2014) An emerging mycoplasma associated with trichomoniasis, vaginal infection and disease. PLoS One 9:e110943
Eaves, Lindon J; Pourcain, Beate St; Smith, George Davey et al. (2014) Resolving the effects of maternal and offspring genotype on dyadic outcomes in genome wide complex trait analysis ("M-GCTA"). Behav Genet 44:445-55
York, Timothy P; Eaves, Lindon J; Neale, Michael C et al. (2014) The contribution of genetic and environmental factors to the duration of pregnancy. Am J Obstet Gynecol 210:398-405
Fettweis, Jennifer M; Brooks, J Paul; Serrano, Myrna G et al. (2014) Differences in vaginal microbiome in African American women versus women of European ancestry. Microbiology 160:2272-82
Chang, Jen Jen; Strauss 3rd, Jerome F; Deshazo, Jon P et al. (2014) Reassessing the impact of smoking on preeclampsia/eclampsia: are there age and racial differences? PLoS One 9:e106446
Seinfeld, Syndi; Shinnar, Shlomo; Sun, Shumei et al. (2014) Emergency management of febrile status epilepticus: results of the FEBSTAT study. Epilepsia 55:388-95
Masho, Saba W; Munn, Meaghan S; Archer, Phillip W (2014) Multilevel factors influencing preterm birth in an urban setting. Urban Plan Transp Res 2:36-48
Vanderbilt, Allison A; Wright, Marcie S (2013) Infant mortality: a call to action overcoming health disparities in the United States. Med Educ Online 18:22503
Strauss 3rd, J F (2013) PLAC4 is upregulated in severe early onset preeclampsia and upregulated with syncytialisation but not hypoxia. Placenta 34:512
Vanhille, Derek L; Hill, Lori D; Hilliard, Dashaunda D et al. (2013) A Novel ERAP2 Haplotype Structure in a Chilean Population: Implications for ERAP2 Protein Expression and Preeclampsia Risk. Mol Genet Genomic Med 1:98-107

Showing the most recent 10 out of 41 publications