Purpose, Structure and Function The overall purpose of the Research Core is to provide a structure that supports the work of the research projects, each of which requires recruitment of human subjects and acquisition of biological samples. Working with Core Investigators, the research Core staff identify potential research subjects, explain the study, assess inclusion and exclusion issues, obtain informed consent, and obtain samples when applicable. The Research Core staff collects and stores samples of DNA from mothers and fathers using buccal swabs, and samples of DNA from babies using sections of umbilical cords. The Core research staff will collect, process and store blood samples and samples of placentas, fetal membranes, decidua and umbilical cords. The Research Core will offer cost-effective approaches to subject recruitment for all three research projects, as well as assistance in methods that will be common to all in terms of tissue acquisition and processing, nucleic acid extraction and quantitation, and histological evaluation of tissues. The Research Core will also facilitate distribution of samples to other University research core services described below. The recruitment needs for each research project are detailed in the individual project descriptions. These recruitment and sample processing needs were developed in consultation with the Research Core Director. The resources of the Research Core were scaled to meet the collective needs of the projects. African Americans comprise 66% of the patients in the Labor and Delivery Unit of MCV Hospitals. In addition, collaborative arrangements have been made with other institutions. Maternal-fetal dyad samples were collected for DNA analysis for Project 1 in collaborative arrangements with the University of Pennsylvania. Hutzel Women's Hospital of Wayne State University and Sotero del Rio Hospital in Santiago, Chile as part of a database of samples from the Perinatology Research Branch, NICHD. The Research Core houses samples until they can be delivered to the investigators. Samples are labeled with the subject number as the only identifier. Investigators using samples will have completed the CITI human subjects research training, have a protocol approved by the VCU-IRB. and have a signed consent form indicating that subjects have agreed to provide samples for the study.

National Institute of Health (NIH)
National Institute on Minority Health and Health Disparities (NIMHD)
Comprehensive Center (P60)
Project #
Application #
Study Section
Special Emphasis Panel (ZMD1)
Project Start
Project End
Budget Start
Budget End
Support Year
Fiscal Year
Total Cost
Indirect Cost
Virginia Commonwealth University
United States
Zip Code
Lind, Mackenzie J; Hawn, Sage E; Sheerin, Christina M et al. (2017) An examination of the etiologic overlap between the genetic and environmental influences on insomnia and common psychopathology. Depress Anxiety 34:453-462
Modi, Bhavi P; Teves, Maria E; Pearson, Laurel N et al. (2017) Rare mutations and potentially damaging missense variants in genes encoding fibrillar collagens and proteins involved in their production are candidates for risk for preterm premature rupture of membranes. PLoS One 12:e0174356
Modi, Bhavi P; Teves, Maria E; Pearson, Laurel N et al. (2017) Mutations in fetal genes involved in innate immunity and host defense against microbes increase risk of preterm premature rupture of membranes (PPROM). Mol Genet Genomic Med 5:720-729
Sheerin, Christina M; Lind, Mackenzie J; Bountress, Kaitlin et al. (2017) The Genetics and Epigenetics of PTSD: Overview, Recent Advances, and Future Directions. Curr Opin Psychol 14:5-11
Brooks, J Paul; Edwards, David J; Blithe, Diana L et al. (2017) Effects of combined oral contraceptives, depot medroxyprogesterone acetate and the levonorgestrel-releasing intrauterine system on the vaginal microbiome. Contraception 95:405-413
Walsh, Scott W; Chumble, Anuja A; Washington, Sonya L et al. (2017) Increased expression of toll-like receptors 2 and 9 is associated with reduced DNA methylation in spontaneous preterm labor. J Reprod Immunol 121:35-41
Modi, Bhavi P; Washington, Sonya; Walsh, Scott W et al. (2017) Expression patterns of the chromosome 21 MicroRNA cluster (miR-99a, miR-125b and let-7c) in chorioamniotic membranes. Placenta 49:1-9
Seinfeld, Syndi A; Pellock, John M; Kjeldsen, Marianne J et al. (2016) Epilepsy After Febrile Seizures: Twins Suggest Genetic Influence. Pediatr Neurol 55:14-6
Abdelmaksoud, Abdallah A; Koparde, Vishal N; Sheth, Nihar U et al. (2016) Comparison of Lactobacillus crispatus isolates from Lactobacillus-dominated vaginal microbiomes with isolates from microbiomes containing bacterial vaginosis-associated bacteria. Microbiology 162:466-75
Kinser, Patricia A; Robins, Jo Lynne W; Masho, Saba W (2016) Self-Administered Mind-Body Practices for Reducing Health Disparities: An Interprofessional Opinion and Call to Action. Evid Based Complement Alternat Med 2016:2156969

Showing the most recent 10 out of 79 publications