This proposal requests support for the ROO phase of the K99/R00 Pathway to Independence Award enabling David Herin, Ph.D, to begin his independent career investigating pharmacological treatments for substance abuse. The first (K99) phase ofthis award has been conducted at the University of Texas Health Science Center at Houston (UTHSC) under Drs. John Grabowski and Joy Schmitz. In this phase, Dr. Herin completed training in clinicai trials metholodology, advanced statistical methods, the responsible conduct of research, as well as u-aining in professional skills. Additionally, Dr. Herin obtained experience in implementation of clinical trials in multiple studies at the UTHSC P50 medication development center, and developed collaborations with departmental faculty. This clinical training has enabled Dr. Herin lo secure a tenure-track faculty position in the Department of Psychiatry at the University of Minnesota. As Dr. Herin launches his independent career, ROO support will enable him to conduct a clinical trial investigating the ability of lisdexamfetamine to treat cocaine dependence. During this ROO period, Dr. Herin will also develop collaborations with his University of Minnesota colleagues in fields such as functional imaging, impulsivity, genetics, and human laboratory studies, enabling submission of future interdisciplinary grant applications to funding agencies. In all, the K99 and ROO awards permit Dr. Herin to begin his independent career and make significant scientific contributions to the field of substance abuse research.

Public Health Relevance

Cocaine dependence is a significant public health problem, and there are no approved medications to treat this disorder. As an extension of our previous work, the current study will investigate the ability of the abuseresistant medication Lisdexamfetamine to treat cocaine dependence.

Agency
National Institute of Health (NIH)
Institute
National Institute on Drug Abuse (NIDA)
Type
Research Transition Award (R00)
Project #
5R00DA023548-05
Application #
8013939
Study Section
Special Emphasis Panel (NSS)
Program Officer
Biswas, Jamie
Project Start
2009-04-01
Project End
2013-01-31
Budget Start
2011-02-01
Budget End
2013-01-31
Support Year
5
Fiscal Year
2011
Total Cost
$239,116
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Psychiatry
Type
Schools of Medicine
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Mooney, Marc E; Herin, David V; Specker, Sheila et al. (2015) Pilot study of the effects of lisdexamfetamine on cocaine use: A randomized, double-blind, placebo-controlled trial. Drug Alcohol Depend 153:94-103
Mooney, Marc E; Odlaug, Brian L; Kim, Suck Won et al. (2011) Cigarette smoking status in pathological gamblers: association with impulsivity and cognitive flexibility. Drug Alcohol Depend 117:74-7
Orozco-Cabal, Luis; Rodríguez, Maritza; Herin, David V et al. (2010) Validity and Reliability of the Abbreviated Barratt Impulsiveness Scale in Spanish (BIS-15S). Rev Colomb Psiquiatr 39:93-109
Mooney, Marc E; Herin, David V; Schmitz, Joy M et al. (2009) Effects of oral methamphetamine on cocaine use: a randomized, double-blind, placebo-controlled trial. Drug Alcohol Depend 101:34-41
Molano-Eslava, Juan Carlos; Iragorri-Cucalon, Angela; Ucros-Rodriguez, Gonzalo et al. (2008) Obsessive-Compulsive Disorder Symptoms in Huntington's Disease: A Case Report. Rev Colomb Psiquiatr 37:644-654
Moeller, F Gerard; Schmitz, Joy M; Herin, David et al. (2008) Use of stimulants to treat cocaine and methamphetamine abuse. Curr Psychiatry Rep 10:385-91