This project outlines technical bioengineering developments for new types of image contrast in the emerging field of hyperpolarized carbon-13 MRI. Preliminary research in this field is extremely promising, particularly for cancer applications, and the first human trials in prostate cancer patients are slated to occur at UCSF within 6 months. This "Pathway to Independence" award application includes a mentored career development plan for transition of the candidate, Dr. Peder Larson, into an independent investigator, as well an accompanying research plan describing the proposed technical developments for hyperpolarized carbon-13 MR. The candidate, Dr. Peder Larson, is currently a Postdoctoral Scholar at UCSF working on technical developments for hyperpolarized carbon-13 MRI. His graduate work was in Electrical Engineering at Stanford and focused on improving MRI of semi-solid tissues, which are invisible in conventional MRI. The mentoring and career development plan will supplement his engineering background with valuable exposure to hyperpolarization physics and chemistry, biological systems and biochemistry, pre-clinical research, and inter-disciplinary collaboration to facilitate the transition to an independent bioengineering investigator. His goals are to become a faculty member in bioengineering or radiology where he can research technical biomedical imaging developments with potential clinical applications. Hyperpolarized carbon-13 MRI requires specialized methods because, unlike conventional MRI, the signal decays rapidly and is unrecoverable. This project proposes rapid and efficient methods for dynamic metabolic imaging to provide localized perfusion, uptake and rate information that are unavailable in current techniques. New sources of contrast with hyperpolarized carbon-13 are also proposed, including a method to distinguish flowing metabolites from those within tissues and development of specialized techniques for multiple carbon-13 agents. Preclinical studies in normal animals will be used for investigation of the new imaging methods. This will facilitate the translation of the methods from development to future clinical application. ) )

Public Health Relevance

MRI with hyperpolarized carbon-13 can non-invasively probe tissue functions that are altered in cancer and other disease states, and the first human trial with prostate cancer patients is shortly forthcoming. The new hyperpolarized carbon-13 imaging methods proposed in this project will provide unprecedented tissue function contrast to improve cancer imaging and potentially enable new clinical applications. )

Agency
National Institute of Health (NIH)
Institute
National Institute of Biomedical Imaging and Bioengineering (NIBIB)
Type
Research Transition Award (R00)
Project #
5R00EB012064-03
Application #
8327061
Study Section
Special Emphasis Panel (NSS)
Program Officer
Liu, Guoying
Project Start
2011-09-01
Project End
2014-08-31
Budget Start
2012-09-01
Budget End
2013-08-31
Support Year
3
Fiscal Year
2012
Total Cost
$228,124
Indirect Cost
$80,471
Name
University of California San Francisco
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
094878337
City
San Francisco
State
CA
Country
United States
Zip Code
94143
Tang, Shuyu; Jiang, Wenwen; Chen, Hsin-Yu et al. (2015) A 2DRF pulse sequence for bolus tracking in hyperpolarized 13C imaging. Magn Reson Med 74:506-12
Shin, Peter J; Larson, Peder E Z; Uecker, Martin et al. (2015) Chemical shift separation with controlled aliasing for hyperpolarized (13) C metabolic imaging. Magn Reson Med 74:978-89
Koelsch, Bertram L; Reed, Galen D; Keshari, Kayvan R et al. (2015) Rapid in vivo apparent diffusion coefficient mapping of hyperpolarized (13) C metabolites. Magn Reson Med 74:622-33
Park, Ilwoo; Larson, Peder E Z; Tropp, James L et al. (2014) Dynamic hyperpolarized carbon-13 MR metabolic imaging of nonhuman primate brain. Magn Reson Med 71:19-25
Swisher, Christine Leon; Larson, Peder E Z; Kruttwig, Klaus et al. (2014) Quantitative measurement of cancer metabolism using stimulated echo hyperpolarized carbon-13 MRS. Magn Reson Med 71:1-11
Shin, Peter J; Larson, Peder E Z; Ohliger, Michael A et al. (2014) Calibrationless parallel imaging reconstruction based on structured low-rank matrix completion. Magn Reson Med 72:959-70
Jiang, Wenwen; Lustig, Michael; Larson, Peder E Z (2014) Concentric rings K-space trajectory for hyperpolarized (13) C MR spectroscopic imaging. Magn Reson Med :
Xing, Yan; Reed, Galen D; Pauly, John M et al. (2013) Optimal variable flip angle schemes for dynamic acquisition of exchanging hyperpolarized substrates. J Magn Reson 234:75-81
Larson, Peder E Z; Hurd, Ralph E; Kerr, Adam B et al. (2013) Perfusion and diffusion sensitive 13C stimulated-echo MRSI for metabolic imaging of cancer. Magn Reson Imaging 31:635-42
Ohliger, Michael A; Larson, Peder E Z; Bok, Robert A et al. (2013) Combined parallel and partial fourier MR reconstruction for accelerated 8-channel hyperpolarized carbon-13 in vivo magnetic resonance Spectroscopic imaging (MRSI). J Magn Reson Imaging 38:701-13

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