Sudden cardiac death (SCD) accounts for -50% of all CHD deaths and, forthe majority of victims, SCD is the first manifestation of heart disease. There is an accumulating body of evidence that fatty acids, particularly n-3 fatty acids, hold great promise as predictors of and preventive interventions against SGD, although studies have been inconsistent. These conflicting results may be due to differences in population characteristics (with and without CHD;men v. women) or methods of fatty acid assessment (dietary intake v. biomarker levels). Thus, more research is needed to understand the differences in risk among these various subgroups and to evaluate different methods of fatty acid measurements. Additionally, genetic and environmental influences on fatty acid metabolism are not well understood. During the K99 award, Dr Chiuve successfully implemerited a comprehensive training plan, which inclijded mentored training through the analysis of dietary fatty acids and genetic influences of fatty acid rnetabolism and risk of SCD, other significant scientific research training, attendance at seminars and researeh conferences and nonscientific career development. She has gained the knowledge and skills necessary for the transition into an independenfinyestigator in the field of """"""""Nutritional Epidemiology of Cardiac Arrhytmic Disorders"""""""". During the ROO phase of the award. Dr. Chiuve w.iil assay fatty acids in fed blood cells and.examine their association with risk of SCD. She will also exaniine the influence of genetic variation in RBC fatty acids. She will investigate these aims within 6 large, NIH-funded prospective cohort studies that include both men and women and individuals with and without established CHD. Strengths of this proposalinclude the use of dietary and RBC fatty acid measures as means to predict individuals at high risk of SCD and the identification of subgroups that may benefit from a low-cost treatment such as modifying dietary fatty acid intake.
These aims correspond to one goal in the NHLBl's strategic plan to """"""""develop means to predict and prevent sudden cardiac death"""""""".

Public Health Relevance

There are up to 400,000 sudden cardiac deaths (SCD) in the US annually and these deaths come with np forewarning. We aim to assess whether blood levels of fatty acids can effectively predict risk of SCD and provide clinicians a non-invasive method to identify patients at high risk of SGD, which is highly relevant to the NHLB's strategic plan.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Transition Award (R00)
Project #
5R00HL097068-04
Application #
8637107
Study Section
Special Emphasis Panel (NSS)
Program Officer
Reis, Jared P
Project Start
2010-09-01
Project End
2016-01-31
Budget Start
2014-02-01
Budget End
2015-01-31
Support Year
4
Fiscal Year
2014
Total Cost
$223,027
Indirect Cost
$44,691
Name
Brigham and Women's Hospital
Department
Type
DUNS #
030811269
City
Boston
State
MA
Country
United States
Zip Code
02115
Sotos-Prieto, Mercedes; Mattei, Josiemer; Hu, Frank B et al. (2016) Association Between a Healthy Heart Score and the Development of Clinical Cardiovascular Risk Factors Among Women: Potential Role for Primordial Prevention. Circ Cardiovasc Qual Outcomes 9:S77-85
Chiuve, Stephanie E; Sandhu, Roopinder K; Moorthy, M Vinayaga et al. (2015) Dietary Fat Intake Is Differentially Associated with Risk of Paroxysmal Compared with Sustained Atrial Fibrillation in Women. J Nutr 145:2092-101
Malik, Vasanti S; Chiuve, Stephanie E; Campos, Hannia et al. (2015) Circulating Very-Long-Chain Saturated Fatty Acids and Incident Coronary Heart Disease in US Men and Women. Circulation 132:260-8
Smith, Caren E; Follis, Jack L; Nettleton, Jennifer A et al. (2015) Dietary fatty acids modulate associations between genetic variants and circulating fatty acids in plasma and erythrocyte membranes: Meta-analysis of nine studies in the CHARGE consortium. Mol Nutr Food Res 59:1373-83
Chiuve, Stephanie E; Sun, Qi; Sandhu, Roopinder K et al. (2015) Adiposity throughout adulthood and risk of sudden cardiac death in women. JACC Clin Electrophysiol 1:520-528
Chiuve, Stephanie E; Sun, Qi; Curhan, Gary C et al. (2013) Dietary and plasma magnesium and risk of coronary heart disease among women. J Am Heart Assoc 2:e000114
Chiuve, Stephanie E; Rimm, Eric B; Sandhu, Roopinder K et al. (2012) Dietary fat quality and risk of sudden cardiac death in women. Am J Clin Nutr 96:498-507