The applicant describes a 5-year career development program leading to independent academic research in biomedical networks under Marco Ramoni and co-mentors David Bates, Isaac Kohane, and Peter Szolovits. The applicant proposes a combined training and research program to lead to independence. Training involves biomedical methods underlying the networks being investigated by the applicant. On the research front, the hypothesis is that a holistic approach to the processing of information in biomedical networks is able to uncover novel types of relationships that could not be identified through current reductionistic methods.
The aims are: 1) Design and develop a methodological framework, based on statistical signal processing, able to analyze biomedical networks and discover hidden relationships. 2) Develop and implement a scalable, modular architecture that is able to adaptively integrate information into the framework described in aim 1. 3) Apply the architecture in specific aim 2 to the development of a system for the analysis of large-scale EHR-based clinical informatics networks.

Agency
National Institute of Health (NIH)
Institute
National Library of Medicine (NLM)
Type
Research Transition Award (R00)
Project #
5R00LM009826-05
Application #
8324015
Study Section
Biomedical Library and Informatics Review Committee (BLR)
Program Officer
Ye, Jane
Project Start
2008-09-30
Project End
2014-09-29
Budget Start
2012-09-30
Budget End
2014-09-29
Support Year
5
Fiscal Year
2012
Total Cost
$238,943
Indirect Cost
$101,619
Name
Children's Hospital Boston
Department
Type
DUNS #
076593722
City
Boston
State
MA
Country
United States
Zip Code
02115
Warner, Jeremy L; Alterovitz, Gil; Bodio, Kelly et al. (2013) External phenome analysis enables a rational federated query strategy to detect changing rates of treatment-related complications associated with multiple myeloma. J Am Med Inform Assoc 20:696-9
Warner, Jeremy; Yang, Peter; Alterovitz, Gil (2013) Automated synthesis and visualization of a chemotherapy treatment regimen network. Stud Health Technol Inform 192:62-6
Alterovitz, Gil; Cavalcanti, Silvio; Muso, Taro M et al. (2011) REVERSE ENGINEERING AND SYNTHESIS OF BIOMOLECULAR SYSTEMS - Session Introduction. Pac Symp Biocomput :300-1