This is ah application for the Independent Phase (ROO) of a Pathway to Independehte Career Development Award. The candidate for this award is James P. Morris, who is currently supported by the K99 mentored phase ofthe Pathway to Indepence Career Development Award. Dr. Morris is a postdoctoral fellow at Yale University working with Dr. Gregory McCarthy a teniired faculty member in the department of psychology. The candidate's postdoctoral research focused on category-specific responses in the temporal cortex, with a special emphasis on brain activity evoked by categories of stimuli withlimportant social meaning. During the mentored phase ofthe award, the candidate leamed to design, conduct, and analyze inti^cranial event-related potential recordings in the human temporal cortex. With this technique, the candidate was able to demonstrate a fimctional dissociation between face and body processing in the fusiform gyrus. Further training focused on the application of modem fMRI unking and analysis techniques such as diffusion tensor imaging and resting connectivity analysis to help elucidate anatomical and functional connections between categOry-specifie brain regions. The independent phase of this award is focused on the development of a research program that seeks to understand the effects of both low-level stimulus factors as well as differences in motivation and behavior on brain activity during social perception. The successful completion of experiinents proposed here will lead to a solid foundation on which to build an independent research career The results from the proposed research will contribute to important discoveries being made regarding the neural correlates of social perception..

Public Health Relevance

Deficits in social perception are a striking feature of autism, schizophrenia, and anxiety disorders. An understanding of how both stimulus and behavioral factors influence social processing will provide suggestions for remediatory approaches toward the treatment of these disorders, as well as the functioning ofthe normal human brain.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Research Transition Award (R00)
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Study Section
Special Emphasis Panel (NSS)
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Simmons, Janine M
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University of Virginia
Schools of Arts and Sciences
United States
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Garman, Heather D; Spaulding, Christine J; Webb, Sara Jane et al. (2016) Wanting it Too Much: An Inverse Relation Between Social Motivation and Facial Emotion Recognition in Autism Spectrum Disorder. Child Psychiatry Hum Dev 47:890-902
Jack, Allison; Morris, James P (2014) Neocerebellar contributions to social perception in adolescents with autism spectrum disorder. Dev Cogn Neurosci 10:77-92
Earls, Holly A; Englander, Zoe A; Morris, James P (2013) Perception of race-related features modulates neural activity associated with action observation and imitation. Neuroreport 24:410-3
Smith, Eric D; Englander, Zoƫ A; Lillard, Angeline S et al. (2013) Cortical mechanisms of pretense observation. Soc Neurosci 8:356-68
Lerner, Matthew D; McPartland, James C; Morris, James P (2013) Multimodal emotion processing in autism spectrum disorders: an event-related potential study. Dev Cogn Neurosci 3:11-21
Englander, Zoe A; Haidt, Jonathan; Morris, James P (2012) Neural basis of moral elevation demonstrated through inter-subject synchronization of cortical activity during free-viewing. PLoS One 7:e39384
Jack, Allison; Englander, Zoe A; Morris, James P (2011) Subcortical contributions to effective connectivity in brain networks supporting imitation. Neuropsychologia 49:3689-98
Heyda, Ratha D; Green, Steven R; Vander Wyk, Brent C et al. (2010) Brain mechanisms for representing what another person sees. Neuroimage 50:693-700
Pelphrey, Kevin A; Lopez, Juliana; Morris, James P (2009) Developmental continuity and change in responses to social and nonsocial categories in human extrastriate visual cortex. Front Hum Neurosci 3:25
Perlman, Susan B; Morris, James P; Vander Wyk, Brent C et al. (2009) Individual differences in personality predict how people look at faces. PLoS One 4:e5952

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