Dr. Christine Wu Nordahl has successfully completed the K99 phase of this award, and will continue on at UC Davis as an Assistant Professor for the ROO phase. Her laboratory will use structural and functional neuroimaging tola to gain understanding about the neuropathology of autism and the developing brain. The overarching research goal of this project is to use a multimodal structural and functional neuroimaging approach to investigating abnormalities in brain structure and connectivity in 2-4-year old children with autism. It is critical to evaluate brain abnormalities as close in time as possible to clinical diagnosis, during critical periods of brain development, and prior to intensive behavioral and medical interventions. Specifically, diffusion tensor imaging and resting state functional connectivity studies will be carried out to explore abnormalities in connectivity in very young children with autism. Additional goals include the evaluation of longitudinal brain growth trajectories during early development and the identification of subgroups or phenotypes within the autism diagnosis. Given the heterogeneity ofthe disorder, multiple etiologies and phenotypes likely exist. The identification of different brain phenotypes may aid in identifying more suitable treatments and interventions for particular subgroups of autism. The research will be carried out at the UC Davis M.I.N.D Institute and Imaging Research Center (IRC). All subject recruitment, diagnoses, and clinical training activities will be carried out at the M.I.N.D. Institute, a translational facility dedicated to developing a cure for autism. All neuroimaging will take place at the IRC, a research dedicated facility with pediatric imaging capabilities.

Public Health Relevance

Autism is a neurodevelopmental disorder that occurs in as many as 1 in 150 children. Understanding the neuropathology of autism is an important first step in developing appropriate treatment plans and potentially a cure for the disorder.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
Research Transition Award (R00)
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Special Emphasis Panel (NSS)
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Gilotty, Lisa
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University of California Davis
Schools of Medicine
United States
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Shen, Mark D; Li, Deana D; Keown, Christopher L et al. (2016) Functional Connectivity of the Amygdala Is Disrupted in Preschool-Aged Children With Autism Spectrum Disorder. J Am Acad Child Adolesc Psychiatry 55:817-24
Ohta, Haruhisa; Nordahl, Christine Wu; Iosif, Ana-Maria et al. (2016) Increased Surface Area, but not Cortical Thickness, in a Subset of Young Boys With Autism Spectrum Disorder. Autism Res 9:232-48
Nordahl, Christine Wu; Iosif, Ana-Maria; Young, Gregory S et al. (2015) Sex differences in the corpus callosum in preschool-aged children with autism spectrum disorder. Mol Autism 6:26
Lee, Joshua K; Nordahl, Christine W; Amaral, David G et al. (2015) Assessing hippocampal development and language in early childhood: Evidence from a new application of the Automatic Segmentation Adapter Tool. Hum Brain Mapp 36:4483-96
Johnson, Ryan T; Yeatman, Jason D; Wandell, Brian A et al. (2014) Diffusion properties of major white matter tracts in young, typically developing children. Neuroimage 88:143-54
Nordahl, Christine Wu; Braunschweig, Daniel; Iosif, Ana-Maria et al. (2013) Maternal autoantibodies are associated with abnormal brain enlargement in a subgroup of children with autism spectrum disorder. Brain Behav Immun 30:61-5
Nordahl, Christine Wu; Scholz, Robert; Yang, Xiaowei et al. (2012) Increased rate of amygdala growth in children aged 2 to 4 years with autism spectrum disorders: a longitudinal study. Arch Gen Psychiatry 69:53-61