I am a 2nd year postdoctoral research scientist who arrived at OHSU after postgraduate training first at Yale University School of Medicine, and subsequently Washington University School of Medicine in St. Louis where I primarily focused on examining typical development of brain organization using fMRI and functional connectivity MRI. My goal is to establish my own independent laboratory in a University setting examining typical and atypical brain development in relation to mental disorders. In particular, I have well thought out ideas for a series of investigations regarding the potential for brain connectivity as a potential endophenotype in ADHD. To conduct such work, I need to gain expertise in issues related to research application of behavioral and clinical assessment, cognitive measures, neuropsychological measures, human subjects issues with clinical populations, and to gain expertise in writing and grantsmanship related to clinical problems. This agenda is the focus of my career development/training plan. The research environment provided by Oregon Health and Science University and the mentor of this award (Dr. Joel Nigg) is outstanding and a perfect fit for my career goals. Dr. Nigg, while not a neuroimager, is a well-known ADHD researcher with more than 10 years of continuous NIH R01 level funding. He has extensive mentoring experience and collaborates with other ADHD researchers around the world, providing ample opportunity for me to meet and interact with experts in many aspects of clinical research. The Pathway to Independence award, with its dual emphasis on training and independence, is an excellent fit for my future career goals. Lay summary of the proposed research plan: It is well established that ADHD is a major public health concern. The proposed study uses a relatively new imaging technique, resting-state functional connectivity MRI, to examine specific circuits and the familiality of these circuits thought to be atypical in ADHD. The result from this study will advance our knowledge regarding the neurobiological underpinnings of ADHD, and assist in the improved characterization of homogeneous subtypes of future investigation.
PI: Fair, Damien A. Project Narrative It is well established that ADHD is a major public health concern. The proposed study uses a relatively new imaging technique, resting-state functional connectivity MRI, to examine specific circuits and the familiality of these circuits thought to be atypical in ADHD. The result from this study will advance our knowledge regarding the neurobiological underpinnings of ADHD, and assist in the improved characterization of homogeneous subtypes of future investigation.
|Graham, Alice M; Buss, Claudia; Rasmussen, Jerod M et al. (2016) Implications of newborn amygdala connectivity for fear and cognitive development at 6-months-of-age. Dev Cogn Neurosci 18:12-25|
|Graham, Alice M; Fair, Damien A (2015) Commentary: Developmental connectomics to advance our understanding of typical and atypical brain development--a commentary on VÃ©rtes and Bullmore (2015). J Child Psychol Psychiatry 56:321-3|
|Graham, Alice M; Pfeifer, Jennifer H; Fisher, Philip A et al. (2015) Early life stress is associated with default system integrity and emotionality during infancy. J Child Psychol Psychiatry 56:1212-22|
|Graham, Alice M; Pfeifer, Jennifer H; Fisher, Philip A et al. (2015) The potential of infant fMRI research and the study of early life stress as a promising exemplar. Dev Cogn Neurosci 12:12-39|
|Costa Dias, Taciana G; Iyer, Swathi P; Carpenter, Samuel D et al. (2015) Characterizing heterogeneity in children with and without ADHD based on reward system connectivity. Dev Cogn Neurosci 11:155-74|
|Ray, Siddharth; Miller, Meghan; Karalunas, Sarah et al. (2014) Structural and functional connectivity of the human brain in autism spectrum disorders and attention-deficit/hyperactivity disorder: A rich club-organization study. Hum Brain Mapp 35:6032-48|
|Karalunas, Sarah L; Fair, Damien; Musser, Erica D et al. (2014) Subtyping attention-deficit/hyperactivity disorder using temperament dimensions: toward biologically based nosologic criteria. JAMA Psychiatry 71:1015-24|
|AlarcÃ³n, Gabriela; Cservenka, Anita; Fair, Damien A et al. (2014) Sex differences in the neural substrates of spatial working memory during adolescence are not mediated by endogenous testosterone. Brain Res 1593:40-54|
|Grayson, David S; Kroenke, Christopher D; Neuringer, Martha et al. (2014) Dietary omega-3 fatty acids modulate large-scale systems organization in the rhesus macaque brain. J Neurosci 34:2065-74|
|Alaerts, Kaat; Woolley, Daniel G; Steyaert, Jean et al. (2014) Underconnectivity of the superior temporal sulcus predicts emotion recognition deficits in autism. Soc Cogn Affect Neurosci 9:1589-600|
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