I am a 2nd year postdoctoral research scientist who arrived at OHSU after postgraduate training first at Yale University School of Medicine, and subsequently Washington University School of Medicine in St. Louis where I primarily focused on examining typical development of brain organization using fMRI and functional connectivity MRI. My goal is to establish my own independent laboratory in a University setting examining typical and atypical brain development in relation to mental disorders. In particular, I have well thought out ideas for a series of investigations regarding the potential for brain connectivity as a potential endophenotype in ADHD. To conduct such work, I need to gain expertise in issues related to research application of behavioral and clinical assessment, cognitive measures, neuropsychological measures, human subjects issues with clinical populations, and to gain expertise in writing and grantsmanship related to clinical problems. This agenda is the focus of my career development/training plan. The research environment provided by Oregon Health and Science University and the mentor of this award (Dr. Joel Nigg) is outstanding and a perfect fit for my career goals. Dr. Nigg, while not a neuroimager, is a well-known ADHD researcher with more than 10 years of continuous NIH R01 level funding. He has extensive mentoring experience and collaborates with other ADHD researchers around the world, providing ample opportunity for me to meet and interact with experts in many aspects of clinical research. The Pathway to Independence award, with its dual emphasis on training and independence, is an excellent fit for my future career goals.

Public Health Relevance

It is well established that ADHD is a major public health concern. The proposed study uses a relatively new imaging technique, resting-state functional connectivity MRI, to examine specific circuits and the familiality of these circuits thought to be atypical in ADHD. The result from this study will advance our knowledge regarding the neurobiological underpinnings of ADHD, and assist in the improved characterization of homogeneous subtypes of future investigation.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Transition Award (R00)
Project #
5R00MH091238-05
Application #
8460943
Study Section
Special Emphasis Panel (NSS)
Program Officer
Friedman-Hill, Stacia
Project Start
2011-09-01
Project End
2014-04-30
Budget Start
2013-05-01
Budget End
2014-04-30
Support Year
5
Fiscal Year
2013
Total Cost
$228,893
Indirect Cost
$80,261
Name
Oregon Health and Science University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
096997515
City
Portland
State
OR
Country
United States
Zip Code
97239
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Graham, Alice M; Fair, Damien A (2015) Commentary: Developmental connectomics to advance our understanding of typical and atypical brain development--a commentary on Vértes and Bullmore (2015). J Child Psychol Psychiatry 56:321-3
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Alarcón, Gabriela; Cservenka, Anita; Fair, Damien A et al. (2014) Sex differences in the neural substrates of spatial working memory during adolescence are not mediated by endogenous testosterone. Brain Res 1593:40-54
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Alaerts, Kaat; Woolley, Daniel G; Steyaert, Jean et al. (2014) Underconnectivity of the superior temporal sulcus predicts emotion recognition deficits in autism. Soc Cogn Affect Neurosci 9:1589-600

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