Effects of Ethanol and CYP2E1 on Liver Function

Cederbaum, Arthur I.

Abstract

Funding Agency

• Agency: National Institute of Health (NIH)
• Institute: National Institute on Alcohol Abuse and Alcoholism (NIAAA)
• Type: Research Project (R01)
• Project #: 5R01AA003312-24
• Application #: 6710575
• Study Section: Alcohol and Toxicology Subcommittee 4 (ALTX)
• Program Officer: Gentry, Thomas
• Project Start: 1982-09-29
• Project End: 2006-02-28
• Budget Start: 2004-03-01
• Budget End: 2005-02-28
• Support Year: 24
• Fiscal Year: 2004
• Total Cost: $339,000

Institution

• Name: Mount Sinai School of Medicine
• Department: Pharmacology
• Type: Schools of Medicine
• DUNS #: 078861598
• City: New York
• State: NY
• Country: United States
• Zip Code: 10029

Publications

Wang, Xiaodong; Wu, Defeng; Yang, Lili et al. (2011) Hepatotoxicity mediated by pyrazole (cytochrome P450 2E1) plus tumor necrosis factor alpha treatment occurs in c-Jun N-terminal kinase 2-/- but not in c-Jun N-terminal kinase 1-/- mice. Hepatology 54:1753-66

Zhuge, Jian; Cederbaum, Arthur I (2009) Inhibition of the mitochondrial permeability transition by cyclosporin A prevents pyrazole plus lipopolysaccharide-induced liver injury in mice. Free Radic Biol Med 46:406-13

Zhuge, Jian (2009) Overexpression of CYP2E1 induces HepG2 cells death by the AMP kinase activator 5'-aminoimidazole-4-carboxamide-1-beta-D-ribofuranoside (AICAR). Cell Biol Toxicol 25:253-63

Wang, Xiaodong; Lu, Yongke; Xie, Bin et al. (2009) Chronic ethanol feeding potentiates Fas Jo2-induced hepatotoxicity: role of CYP2E1 and TNF-alpha and activation of JNK and P38 MAP kinase. Free Radic Biol Med 47:518-28

Cederbaum, Arthur (2009) Nrf2 and antioxidant defense against CYP2E1 toxicity. Expert Opin Drug Metab Toxicol 5:1223-44

Wang, Xiaodong; Cederbaum, Arthur I (2007) Acute ethanol pretreatment increases FAS-mediated liver injury in mice: role of oxidative stress and CYP2E1-dependent and -independent pathways. Free Radic Biol Med 42:971-84