Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
5R01AA004732-16
Application #
2043075
Study Section
Biochemistry, Physiology and Medicine Subcommittee (ALCB)
Project Start
1980-09-28
Project End
2000-08-31
Budget Start
1996-09-01
Budget End
1997-08-31
Support Year
16
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Kansas Lawrence
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
072933393
City
Lawrence
State
KS
Country
United States
Zip Code
66045
Wang, Xinkun; Patel, Nilam D; Hui, Dongwei et al. (2014) Gene expression patterns in the hippocampus during the development and aging of Glud1 (Glutamate Dehydrogenase 1) transgenic and wild type mice. BMC Neurosci 15:37
Hascup, Kevin N; Bao, Xiaodong; Hascup, Erin R et al. (2011) Differential levels of glutamate dehydrogenase 1 (GLUD1) in Balb/c and C57BL/6 mice and the effects of overexpression of the Glud1 gene on glutamate release in striatum. ASN Neuro 3:
Michaelis, E K; Wang, X; Pal, R et al. (2011) Neuronal Glud1 (glutamate dehydrogenase 1) over-expressing mice: increased glutamate formation and synaptic release, loss of synaptic activity, and adaptive changes in genomic expression. Neurochem Int 59:473-81
Wang, Xinkun; Bao, Xiaodong; Pal, Ranu et al. (2010) Transcriptomic responses in mouse brain exposed to chronic excess of the neurotransmitter glutamate. BMC Genomics 11:360
Wang, Xinkun; Michaelis, Elias K (2010) Selective neuronal vulnerability to oxidative stress in the brain. Front Aging Neurosci 2:12
Hui, Dongwei; Kumar, Keshava N; Mach, Julie R et al. (2009) A rat brain bicistronic gene with an internal ribosome entry site codes for a phencyclidine-binding protein with cytotoxic activity. J Biol Chem 284:2245-57
Bao, Xiaodong; Pal, Ranu; Hascup, Kevin N et al. (2009) Transgenic expression of Glud1 (glutamate dehydrogenase 1) in neurons: in vivo model of enhanced glutamate release, altered synaptic plasticity, and selective neuronal vulnerability. J Neurosci 29:13929-44
Pal, Ranu; Agbas, Abdulbaki; Bao, Xiaodong et al. (2003) Selective dendrite-targeting of mRNAs of NR1 splice variants without exon 5: identification of a cis-acting sequence and isolation of sequence-binding proteins. Brain Res 994:1-18
Leonard, C S; Michaelis, E K; Mitchell, K M (2001) Activity-dependent nitric oxide concentration dynamics in the laterodorsal tegmental nucleus in vitro. J Neurophysiol 86:2159-72
Hui, D; Bao, X; Michaelis, E K (2001) High-probability amplification of genomic DNA starting from cDNA. Biotechniques 31:268-70, 272

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