It is now well-established that the development of alcoholism is influenced by genetic factors. The presence of genetic factors has led to a search for potential phenotypic markers. There is currently much scientific evidence to suggest that certain eventrelated potentials (ERP) anomalies are typically observed in young males found to be at high risk for developing alcoholism. Several investigators have reported that high risk males manifest a lower P3 amplitude of the ERP compared to low risk. We propose to develop data analytic techniques which will enable us to examine the amplitude of the P3 component in individual ERP trails. We plan to develop mathematical tools to estimate the potential sites of equivalent dipoles in a 3D model of the brain. Moreover, we will examine other ERP components such as P3a, Owave, N400, Readiness Potential and CNV in order to test specific hypotheses about young males (between 14 and 19 years) who are offsprings of male alcoholics with a multigenerational incidence of alcoholism. In addition we will test low risk subjects who will be matched on several demographic variables to high risk subjects. The identification of neurophysiological phenotypic markers may have clinical utility in the prevention of alcoholism.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
5R01AA005524-10
Application #
2043292
Study Section
Biochemistry, Physiology and Medicine Subcommittee (ALCB)
Project Start
1982-07-01
Project End
1995-12-31
Budget Start
1992-01-01
Budget End
1992-12-31
Support Year
10
Fiscal Year
1992
Total Cost
Indirect Cost
Name
Suny Downstate Medical Center
Department
Psychiatry
Type
Schools of Medicine
DUNS #
068552207
City
Brooklyn
State
NY
Country
United States
Zip Code
11203
Pandey, Ashwini Kumar; Ardekani, Babak Assai; Kamarajan, Chella et al. (2018) Lower Prefrontal and Hippocampal Volume and Diffusion Tensor Imaging Differences Reflect Structural and Functional Abnormalities in Abstinent Individuals with Alcohol Use Disorder. Alcohol Clin Exp Res 42:1883-1896
Kamarajan, Chella; Pandey, Ashwini K; Chorlian, David B et al. (2017) A KCNJ6 gene polymorphism modulates theta oscillations during reward processing. Int J Psychophysiol 115:13-23
Kuperman, Samuel; Chan, Grace; Kramer, John et al. (2017) A GABRA2 polymorphism improves a model for prediction of drinking initiation. Alcohol 63:1-8
Pandey, Ashwini K; Kamarajan, Chella; Manz, Niklas et al. (2016) Delta, theta, and alpha event-related oscillations in alcoholics during Go/NoGo task: Neurocognitive deficits in execution, inhibition, and attention processing. Prog Neuropsychopharmacol Biol Psychiatry 65:158-71
Kamarajan, Chella; Pandey, Ashwini K; Chorlian, David B et al. (2015) Deficient Event-Related Theta Oscillations in Individuals at Risk for Alcoholism: A Study of Reward Processing and Impulsivity Features. PLoS One 10:e0142659
Kamarajan, Chella; Pandey, Ashwini K; Chorlian, David B et al. (2015) The use of current source density as electrophysiological correlates in neuropsychiatric disorders: A review of human studies. Int J Psychophysiol 97:310-22
Kamarajan, Chella; Pandey, Ashwini K; Chorlian, David B et al. (2015) Reward processing deficits and impulsivity in high-risk offspring of alcoholics: A study of event-related potentials during a monetary gambling task. Int J Psychophysiol 98:182-200
Kamarajan, Chella; Porjesz, Bernice (2015) Advances in Electrophysiological Research. Alcohol Res 37:53-87
Rangaswamy, Madhavi; Porjesz, Bernice (2014) Understanding alcohol use disorders with neuroelectrophysiology. Handb Clin Neurol 125:383-414
Pandey, A K; Kamarajan, C; Tang, Y et al. (2012) Neurocognitive deficits in male alcoholics: an ERP/sLORETA analysis of the N2 component in an equal probability Go/NoGo task. Biol Psychol 89:170-82

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