Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
5R01AA009300-03
Application #
2045526
Study Section
Biochemistry, Physiology and Medicine Subcommittee (ALCB)
Project Start
1993-07-01
Project End
1997-03-31
Budget Start
1995-07-01
Budget End
1997-03-31
Support Year
3
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Colorado Denver
Department
Pharmacology
Type
Schools of Pharmacy
DUNS #
065391526
City
Aurora
State
CO
Country
United States
Zip Code
80045
Shearn, Colin T; Pulliam, Casey F; Pedersen, Kim et al. (2018) Knockout of the Gsta4 Gene in Male Mice Leads to an Altered Pattern of Hepatic Protein Carbonylation and Enhanced Inflammation Following Chronic Consumption of an Ethanol Diet. Alcohol Clin Exp Res 42:1192-1205
Li, Yong-Xiang; Zhao, Xixi; Xie, Siyi et al. (2018) Paleomagnetism of IODP Site U1380: Implications for the Forearc Deformation in the Costa Rican Erosive Convergent Margin. Sci Rep 8:11430
Shearn, Colin T; Orlicky, David J; Petersen, Dennis R (2018) Dysregulation of antioxidant responses in patients diagnosed with concomitant Primary Sclerosing Cholangitis/Inflammatory Bowel Disease. Exp Mol Pathol 104:1-8
Shearn, Colin T; Saba, Laura M; Roede, James R et al. (2017) Differential carbonylation of proteins in end-stage human fatty and nonfatty NASH. Free Radic Biol Med 113:280-290
Shearn, Colin T; Fritz, Kristofer S; Shearn, Alisabeth H et al. (2016) Deletion of GSTA4-4 results in increased mitochondrial post-translational modification of proteins by reactive aldehydes following chronic ethanol consumption in mice. Redox Biol 7:68-77
Ronis, Martin J J; Mercer, Kelly E; Gannon, Brenda et al. (2015) Increased 4-hydroxynonenal protein adducts in male GSTA4-4/PPAR-? double knockout mice enhance injury during early stages of alcoholic liver disease. Am J Physiol Gastrointest Liver Physiol 308:G403-15
Shearn, C T; Orlicky, D J; Saba, L M et al. (2015) Increased hepatocellular protein carbonylation in human end-stage alcoholic cirrhosis. Free Radic Biol Med 89:1144-53
Caro, Andres A; Bell, Matthew; Ejiofor, Shannon et al. (2014) N-acetylcysteine inhibits the up-regulation of mitochondrial biogenesis genes in livers from rats fed ethanol chronically. Alcohol Clin Exp Res 38:2896-906
Galligan, James J; Fritz, Kristofer S; Backos, Donald S et al. (2014) Oxidative stress-mediated aldehyde adduction of GRP78 in a mouse model of alcoholic liver disease: functional independence of ATPase activity and chaperone function. Free Radic Biol Med 73:411-20
Shearn, Colin T; Smathers, Rebecca L; Jiang, Hua et al. (2013) Increased dietary fat contributes to dysregulation of the LKB1/AMPK pathway and increased damage in a mouse model of early-stage ethanol-mediated steatosis. J Nutr Biochem 24:1436-45

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