We propose to continue a longitudinal study of 717 pairs of female twins from two population-based cohorts with the aim of understanding the origins and consequences of substance use disorders (SUDs). Specifically, we hypothesize that inherited vulnerability in two systems, disinhibition and negative affect, interacts with adolescent and early-adult experience and life circumstance to affect the likelihood of SUDs in adulthood. Through use of overlapping cohorts, we will chart the development of SUDs from pre-adolescence through early adulthood. The younger cohort, originally assessed at age 11, will be followed through age 24-25; the older cohort, originally assessed at age 17, will be followed through age 29-30. Participants complete a comprehensive in-person assessment that includes clinical interviews, psychophysiological indicators of risk, and self-reports of personality and environmental risk. DNA samples will also be obtained to enable future molecular genetic investigation. Analysis of data from early waves has allowed us to characterize a disinhibitory pathway that: 1) begins in pre-adolescence with early manifestations of problem behavior, 2) is predictive of SUD risk, 3) underlies the comorbidity of a wide range of disruptive disorders, 4) is substantially heritable, and 5) is indexed by psychophysiological markers of risk, like P3. Although the effects are not as marked, we have also shown that negative emotionality and internalizing disorders are associated with and prospectively predict the onset of SUDs in adulthood. Analysis of data from the proposed adult assessments will allow us to investigate the impact of these two pathways on the persistence and desistence of substance use and abuse at these life stages.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
5R01AA009367-16
Application #
7322139
Study Section
Social Sciences, Nursing, Epidemiology and Methods 4 (SNEM)
Program Officer
Breslow, Rosalind
Project Start
1992-09-01
Project End
2009-09-29
Budget Start
2007-12-01
Budget End
2009-09-29
Support Year
16
Fiscal Year
2008
Total Cost
$619,205
Indirect Cost
Name
University of Minnesota Twin Cities
Department
Psychology
Type
Schools of Arts and Sciences
DUNS #
555917996
City
Minneapolis
State
MN
Country
United States
Zip Code
55455
Elkins, Irene J; Saunders, Gretchen R B; Malone, Stephen M et al. (2018) Mediating pathways from childhood ADHD to adolescent tobacco and marijuana problems: roles of peer impairment, internalizing, adolescent ADHD symptoms, and gender. J Child Psychol Psychiatry 59:1083-1093
Harper, Jeremy; Malone, Stephen M; Iacono, William G (2018) Conflict-related medial frontal theta as an endophenotype for alcohol use disorder. Biol Psychol 139:25-38
Elkins, Irene J; Saunders, Gretchen R B; Malone, Stephen M et al. (2018) Associations between childhood ADHD, gender, and adolescent alcohol and marijuana involvement: A causally informative design. Drug Alcohol Depend 184:33-41
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Park, Jun Young; Wu, Chong; Basu, Saonli et al. (2018) Adaptive SNP-Set Association Testing in Generalized Linear Mixed Models with Application to Family Studies. Behav Genet 48:55-66
Bornovalova, Marina A; Verhulst, Brad; Webber, Troy et al. (2018) Genetic and environmental influences on the codevelopment among borderline personality disorder traits, major depression symptoms, and substance use disorder symptoms from adolescence to young adulthood. Dev Psychopathol 30:49-65
Lee, James J; McGue, Matt; Iacono, William G et al. (2018) The accuracy of LD Score regression as an estimator of confounding and genetic correlations in genome-wide association studies. Genet Epidemiol 42:783-795
Foster, Katherine T; Arterberry, Brooke J; Iacono, William G et al. (2018) Psychosocial functioning among regular cannabis users with and without cannabis use disorder. Psychol Med 48:1853-1861
Waldron, Jordan Sparks; Malone, Stephen M; McGue, Matt et al. (2018) A Co-Twin Control Study of the Relationship Between Adolescent Drinking and Adult Outcomes. J Stud Alcohol Drugs 79:635-643
Korotana, Laurel M; von Ranson, Kristin M; Wilson, Sylia et al. (2018) Reciprocal Associations Between Eating Pathology and Parent-Daughter Relationships Across Adolescence: A Monozygotic Twin Differences Study. Front Psychol 9:914

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