Acute alcohol consumption by lactating women impacts upon infant nutrition and behavior, the lactational performance of the mother and her interaction with the infant, and the sensory qualities of human milk. The ultimate goal of this project is to investigate the short- term effects and the mechanism of mechanisms underlying these changes from the perspective of both mother and infant, with a practical aim of providing information on a much neglected area in scientific research. First, we aim to determine the effects of lactational alcohol exposure on the infant's regulation of milk intake and sleep-wake patterning, and to assess how maternal beliefs about alcohol impact upon their interaction with their infants. Second, we aim to determine how ethanol consumption affects the endocrine milieu of the lactating woman and how such alterations impact upon lactational performance.
The third aim explores the role of experiences with alcohol in mother's milk on the recognition and preference for the sensory properties of alcohol during infancy and childhood since non-human animal studies have revealed that early exposure to alcohol affects later preferences. These studies will have important ramifications for our understanding of issues relating to women's health during lactation and the effects of early experience with alcohol on infant nutrition, development and later preferences.

Agency
National Institute of Health (NIH)
Institute
National Institute on Alcohol Abuse and Alcoholism (NIAAA)
Type
Research Project (R01)
Project #
5R01AA009523-07
Application #
2894046
Study Section
Special Emphasis Panel (ZRG4-ALTX-3 (01))
Program Officer
Foudin, Laurie L
Project Start
1998-09-24
Project End
2002-08-31
Budget Start
1999-09-01
Budget End
2000-08-31
Support Year
7
Fiscal Year
1999
Total Cost
Indirect Cost
Name
Monell Chemical Senses Center
Department
Type
DUNS #
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Mennella, Julie A; Pepino, Marta Yanina; Duke, Fujiko F et al. (2011) Psychophysical dissection of genotype effects on human bitter perception. Chem Senses 36:161-7
Mennella, Julie A; Lukasewycz, Laura D; Griffith, James W et al. (2011) Evaluation of the Monell forced-choice, paired-comparison tracking procedure for determining sweet taste preferences across the lifespan. Chem Senses 36:345-55
Mennella, Julie A; Pepino, M Yanina; Duke, Fujiko F et al. (2010) Age modifies the genotype-phenotype relationship for the bitter receptor TAS2R38. BMC Genet 11:60
Mennella, Julie A; Pepino, M Yanina (2010) Breast pumping and lactational state exert differential effects on ethanol pharmacokinetics. Alcohol 44:141-8
Mennella, Julie A; Pepino, Marta Yanina (2010) Breastfeeding and prolactin levels in lactating women with a family history of alcoholism. Pediatrics 125:e1162-70
Pepino, M Yanina; Finkbeiner, Susana; Beauchamp, Gary K et al. (2010) Obese women have lower monosodium glutamate taste sensitivity and prefer higher concentrations than do normal-weight women. Obesity (Silver Spring) 18:959-65
Mennella, Julie A; Pepino, M Yanina; Lehmann-Castor, Sara M et al. (2010) Sweet preferences and analgesia during childhood: effects of family history of alcoholism and depression. Addiction 105:666-75
Pepino, M Yanina; Finkbeiner, Susana; Mennella, Julie A (2009) Similarities in food cravings and mood states between obese women and women who smoke tobacco. Obesity (Silver Spring) 17:1158-63
Mennella, J A (2009) Flavour programming during breast-feeding. Adv Exp Med Biol 639:113-20
Mennella, Julie A; Pepino, Marta Yanina (2008) Biphasic effects of moderate drinking on prolactin during lactation. Alcohol Clin Exp Res 32:1899-908

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